Research on Bending Fatigue Properties of Reinforced Macadam Foundation

Existing macadam base structures have poor resistance to bending deformation of pavement. The structural layer is challenged with serious cracking due to the long-term dynamic loads. Despite these issues, however, studies on reinforcement techniques for macadam base structure have been scarce. No reasonable and feasible method on how to improve the bending resistance of flexible base structures (e.g. macadam base structure) and prolong their bending fatigue life has yet been reported. Thus, this study proposed a method for reinforcing macadam base structures with geogrids to strengthen bending performance, anti-fatigue performance and dynamic stability of flexible base structures under different loading levels. The reinforced macadam base structure was investigated through a laboratory test of flexural-tensile strength and a three-point fatigue bending test. A cyclic loading test of reinforced and non-reinforced girder specimens was carried out under five stress levels. The effect of such a new reinforcement method in improving the bending fatigue properties of macadam base structures was analyzed by comparing the yield curves and fatigue lives of reinforced and non-reinforced specimens under different loading levels. Results demonstrate that the non-reinforced macadam base has poor bending resistance. The yield curve and fatigue life of non-reinforced specimens attenuated quickly as it approached the ultimate loading level. Non-reinforced specimens have low-cycle fatigue failures when the loads reach the 0.8 stress level and the ultimate displacement at failure is relatively small, accompanied by obvious failure surface. After geogrids are added, the fatigue life of specimens improved significantly. The yield curve shows no significant attenuation at a high loading level. The reinforced specimens can still maintain high-cycle fatigue failure under the 0.8 stress level and avoid the occurrence of low-cycle fatigue failures. Moreover, reinforced specimens can inhibit transmission of reflection cracks at midspan of cement-stabilized macadam base, delay the propagation of oblique shearing fractures close to the support, and strengthen the dynamic stability and durability of pavement structure with a macadam base. The conclusions of this study provide theoretical references to practical engineering applications of such new reinforcement technology for macadam bases

Discrete Element Simulation of Bending Deformation of Geogrid-Reinforced Macadam Base

The pavement bending deformation resistance of the existing macadam base structure is poor. The geogrid-reinforced macadam base can effectively strengthen the bending resistance of the pavement, but no international consensus has been reached at present over bending failure laws of reinforced macadam base structure. Discrete element models of semi-rigid base pavement structure, macadam base pavement structure, and geogrid-reinforced macadam base pavement structure were built based on MATDEM discrete element simulation program; loading calculation of the three models was conducted by taking their centers as loading positions; and model displacement nephogram, strain nephogram, and effects of different spans on their bending deformation were analyzed to reveal bending failure laws of reinforced macadam base and improvement effect of the geogrid on the anti-bending performance of the macadam structural layer. Finally, bending deformation laws of the three pavement structures and improvement effect of geogrid reinforcement on bending properties of the macadam base structure were established. The results show that under bending deformation of semi-rigid base, the vertical strain at the contract surface between the baseplate and soil base and horizontal strain at midspan position reach the maximum, which can easily lead to fracture and shear failure, and the macadam base layer can effectively isolate the tensile strain transmitted from bottom up. Through their own deformation, grids can transform surface pressure load into frictional resistance at the geogrid/soil interface and partial kinetic energy in the system into their own elastic potential energy to reduce the kinetic energy at the subbase layer. Geogrid reinforcement can improve the nonlinearity of macadam materials, reduce the fluctuation amplitude of the strain curve and displacement curve, lengthen the service life of the macadam base pavement structure, and improve its structural soundness under bending deformation. This study can provide a theoretical reference for numerical simulation of bending failure of geogrid-reinforced macadam base

Analysis on Drivers\u27 Vision-psychology under the Influence of Color Difference after Pavement Pothole Repair

Pavement pothole repair, as one of the commonest methods used in routine road maintenance works, is effective to extend the pavement service life and increase its transport capacity. However, there are significant color differences between the old and new pavements after pothole repair, and there are few studies about the impact of color differences on driving safety. Thus, using multiple typical pavements with the pothole repair, we aim to reveal the impact of the color differences between the old and new materials on the driving safety, and to improve the safety and comfort of drivers. Tobii eye tracker and the ErgoLAB physiological recorder were used to test the driver\u27s visual parameters when the vehicles run under the pothole repair environment, including drivers\u27 gaze frequency, gaze duration, saccade range and heart rate variability. Results show that the color differences of the road after pothole repair have a significant influence on the drivers\u27 vision and psychology, resulting in reduced driving safety and stability. Compared with the unrepaired road section, the gaze frequency and duration of drivers on pothole sections are significantly increased. The speed of saccade is also increased, and the saccade range is reduced. Meanwhile, the average heart rate of drivers on the pothole sections is increased by 10-20%, indicating that drivers\u27 attention and heart rate fluctuate greatly when passing through potholes, which can easily cause emotional tension and misjudgment, and thereby reduce the safety of driving. The obtained conclusions provide a significant reference for subsequent research

An Evidence-Based Review of Related Metabolites and Metabolic Network Research on Cerebral Ischemia

In recent years, metabolomics analyses have been widely applied to cerebral ischemia research. This paper introduces the latest proceedings of metabolomics research on cerebral ischemia. The main techniques, models, animals, and biomarkers of cerebral ischemia will be discussed. With analysis help from the MBRole website and the KEGG database, the altered metabolites in rat cerebral ischemia were used for metabolic pathway enrichment analyses. Our results identify the main metabolic pathways that are related to cerebral ischemia and further construct a metabolic network. These results will provide useful information for elucidating the pathogenesis of cerebral ischemia, as well as the discovery of cerebral ischemia biomarkers

Pathologically Activated Neuroprotection via Uncompetitive Blockade of \u3cem\u3eN\u3c/em\u3e-Methyl-d-aspartate Receptors with Fast Off-rate by Novel Multifunctional Dimer Bis(propyl)-cognitin

Uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonists with fast off-rate (UFO) may represent promising drug candidates for various neurodegenerative disorders. In this study, we report that bis(propyl)-cognitin, a novel dimeric acetylcholinesterase inhibitor and γ-aminobutyric acid subtype A receptor antagonist, is such an antagonist of NMDA receptors. In cultured rat hippocampal neurons, we demonstrated that bis(propyl)-cognitin voltage-dependently, selectively, and moderately inhibited NMDA-activated currents. The inhibitory effects of bis(propyl)-cognitin increased with the rise in NMDA and glycine concentrations. Kinetics analysis showed that the inhibition was of fast onset and offset with an off-rate time constant of 1.9 s. Molecular docking simulations showed moderate hydrophobic interaction between bis(propyl)-cognitin and the MK-801 binding region in the ion channel pore of the NMDA receptor. Bis(propyl)-cognitin was further found to compete with [3H]MK-801 with a Ki value of 0.27 μm, and the mutation of NR1(N616R) significantly reduced its inhibitory potency. Under glutamate-mediated pathological conditions, bis(propyl)-cognitin, in contrast to bis(heptyl)-cognitin, prevented excitotoxicity with increasing effectiveness against escalating levels of glutamate and much more effectively protected against middle cerebral artery occlusion-induced brain damage than did memantine. More interestingly, under NMDA receptor-mediated physiological conditions, bis(propyl)-cognitin enhanced long-term potentiation in hippocampal slices, whereas MK-801 reduced and memantine did not alter this process. These results suggest that bis(propyl)-cognitin is a UFO antagonist of NMDA receptors with moderate affinity, which may provide a pathologically activated therapy for various neurodegenerative disorders associated with NMDA receptor dysregulation

Projection-Based Reduced Order Modeling for Spacecraft Thermal Analysis

This paper presents a mathematically rigorous, subspace projection-based reduced order modeling (ROM) methodology and an integrated framework to automatically generate reduced order models for spacecraft thermal analysis. Two key steps in the reduced order modeling procedure are described: (1) the acquisition of a full-scale spacecraft model in the ordinary differential equation (ODE) and differential algebraic equation (DAE) form to resolve its dynamic thermal behavior; and (2) the ROM to markedly reduce the dimension of the full-scale model. Specifically, proper orthogonal decomposition (POD) in conjunction with discrete empirical interpolation method (DEIM) and trajectory piece-wise linear (TPWL) methods are developed to address the strong nonlinear thermal effects due to coupled conductive and radiative heat transfer in the spacecraft environment. Case studies using NASA-relevant satellite models are undertaken to verify the capability and to assess the computational performance of the ROM technique in terms of speed-up and error relative to the full-scale model. ROM exhibits excellent agreement in spatiotemporal thermal profiles (<0.5% relative error in pertinent time scales) along with salient computational acceleration (up to two orders of magnitude speed-up) over the full-scale analysis. These findings establish the feasibility of ROM to perform rational and computationally affordable thermal analysis, develop reliable thermal control strategies for spacecraft, and greatly reduce the development cycle times and costs