Experimental Investigation on the Tensile Strength of Coal: Consideration of the Specimen Size and Water Content

We experimentally and theoretically explored the microstructure-related effects of water and specimen size on the tensile strength of coal. Cylindrical coal specimens with different sizes (diameters of 25, 38, and 50 mm) and water contents (immersion time lengths: 0, 4, and 7 days) were processed. The microscopic features and mineral compositions of the coal samples were imaged and characterized via scanning electron microscopy (SEM) and X-ray diffraction (XRD). The physicochemical effects of water on the microstructures and coal matrices were investigated by acoustic emission (AE) and fractal theory. In this research, the tensile strength was found to be reduced in larger specimens, which can be explained by an exponential correlation. Water enhances the scale effect on the tensile strength of coal, although the water content decreases in larger specimens. Meanwhile, greater reductions in tensile strength were observed under the coupled effects of the water and specimen size. Based on the AE variation and fractal feature analysis, water was considered to mainly plays roles in dissolving clay minerals, softening the coal matrix, and lubricating cracks during the tensile failure of coal. In addition, the cumulative AE counts and absolute AE energy values decreased with the water content and increased with the specimen size. Similar variations were also observed in the fractal dimension, indicating the intensification of the AE activity concentration around the peak strength area in specimens with greater water contents, as well as a concentration reduction in larger specimen sizes with different water contents. The percentage of tensile failure increased in the diameter range of 25–38 mm and decreased in the range of 38–50 mm. Water increases the proportion of tensile strength generated during the tensile failure process, and this effects increases with the immersion time. Thus, consideration should be given to the combined water and scale effects when extrapolating lab-investigation results to water-related engineering issues in coal mines

Self-Control of Inflammation during Tail Regeneration of Lizards

Lizards can spontaneously regenerate their lost tail without evoking excessive inflammation at the damaged site. In contrast, tissue/organ injury of its mammalian counterparts results in wound healing with a formation of a fibrotic scar due to uncontrolled activation of inflammatory responses. Unveiling the mechanism of self-limited inflammation occurring in the regeneration of a lizard tail will provide clues for a therapeutic alternative to tissue injury. The present review provides an overview of aspects of rapid wound healing and roles of antibacterial peptides, effects of leukocytes on the tail regeneration, self-blocking of the inflammatory activation in leukocytes, as well as inflammatory resistance of blastemal cells or immature somatic cells during lizard tail regeneration. These mechanistic insights of self-control of inflammation during lizard tail regeneration may lead in the future to the development of therapeutic strategies to fight injury-induced inflammation

Self-Control of Inflammation during Tail Regeneration of Lizards

Lizards can spontaneously regenerate their lost tail without evoking excessive inflammation at the damaged site. In contrast, tissue/organ injury of its mammalian counterparts results in wound healing with a formation of a fibrotic scar due to uncontrolled activation of inflammatory responses. Unveiling the mechanism of self-limited inflammation occurring in the regeneration of a lizard tail will provide clues for a therapeutic alternative to tissue injury. The present review provides an overview of aspects of rapid wound healing and roles of antibacterial peptides, effects of leukocytes on the tail regeneration, self-blocking of the inflammatory activation in leukocytes, as well as inflammatory resistance of blastemal cells or immature somatic cells during lizard tail regeneration. These mechanistic insights of self-control of inflammation during lizard tail regeneration may lead in the future to the development of therapeutic strategies to fight injury-induced inflammation

Scale Effect on the Anisotropy of Acoustic Emission in Coal

Acoustic emission (AE) in coal is anisotropic. In this paper, we investigate the microstructure-related scale effect on the anisotropic AE feature in coal at unconfined loading process. A series of coal specimens were processed with diameters of 25 mm, 38 mm, 50 mm, and 75 mm (height to diameter ratio of 2) and anisotropic angles of 0°, 15°, 30°, 45°, 60°, and 90°. The cumulative AE counts and energy dissipation increase with the specimen size, while the energy dissipation per AE count behaves in the opposite way. This may result from the increasing amount of both preexisting discontinuities and cracks (volume/number) needed for specimen failure and the lower energy dissipation AE counts generated by them. The effect of microstructures on the anisotropies of AE weakens with the increasing specimen size. The TRFD and its anisotropy reduce as the specimen size increases, and the reduction of fractal dimension is most pronounced at the anisotropic angle of 45°. The correlation between TRFD and cumulative AE energy in the specimens with different sizes are separately consistent with the negative exponential equation proposed by Xie and Pariseau. With the specimen size gain, the reduction of the TRFD weakens with the increasing amount of cumulative absolute AE energy

Characteristics of Pore and Fracture of Coal with Bursting Proneness Based on DIC and Fractal Theory

Coal is a complex heterogeneous and anisotropic material conformed with fractal characteristics. The pore and fracture characteristics have important influence on the dynamic disasters including rock burst and gas outburst, however, the relationship between them is not accurately investigated due to inadequate research method. The pore and fracture distribution of coal with different bursting proneness were obtained by comprehensive application of MIP, LTNAD, SEM, and X-ray CT, and then fractal theory and DIC were used to research the pore and fracture characteristics. The result indicated that the modification of MIP result by LTNAD result could effectively eliminate the adverse effect of coal matrix compressibility, exactly reflect the distribution of pore and fracture in coal, and the pore distribution of coal with different bursting proneness were quite different. Gray scale image from SEM and 3D reconstruction technology based on X-ray CT could show the geological structure, fracture structure, and pore structure characteristics of coal. The study of LTNAD, SEM, and X-ray CT showed that these methods complemented each other, the coal had fractal properties, and the fractal dimension value had a positive correlation with the bursting proneness of coal sample

Biocontrol of Candida albicans by Antagonistic Microorganisms and Bioactive Compounds

Candida albicans is an endogenous opportunistic pathogenic fungus that is harmless when the host system remains stable. However, C. albicans could seriously threaten human life and health when the body’s immune function declines or the normal flora is out of balance. Due to the increasing resistance of candidiasis to existing drugs, it is important to find new strategies to help treat this type of systemic fungal disease. Biological control is considered as a promising strategy which is more friendly and safer. In this review, we compare the bacteriostatic behavior of different antagonistic microorganisms (bacteria and fungi) against C. albicans. In addition, natural products with unique structures have attracted researchers’ attention. Therefore, the bioactive nature products produced by different microorganisms and their possible inhibitory mechanisms are also reviewed. The application of biological control strategies and the discovery of new compounds with antifungal activity will reduce the resistance of C. albicans, thereby promoting the development of novel diverse antifungal drugs

The Effect of Dietary Protein Intake on the Risk of Gestational Diabetes

Background. The results of epidemiological studies on the association between dietary protein intake and gestational diabetes mellitus (GDM) are controversial. Thus, this systematic review and meta-analysis of cohort studies were established to attain comprehensive findings regarding the association between dietary protein and the risk of GDM. Methods. Bibliographic databases including PubMed, Scopus, Web of Science, and Google Scholar were searched to discover papers related to dietary protein and the risk of GDM. The summary relative risks with 95% confidence intervals (CIs) were estimated through a random effect model for the analysis of the highest versus the lowest categories of dietary proteins. Results. A significantly increased risk of GDM among women who consumed the highest amount of animal protein was observed (summarized risk estimate: 1.52; 95% CI: 1.07, 2.17; I2 = 50.8%). No significant associations were identified regarding vegetable protein (summarized risk estimate:0.99, 95% CI: 0.80 to 1.23, I2 = 63.8%) and total protein (summarized risk estimate: 1.12; 95% CI: 0.88, 1.41; I2 = 35.4%). Conclusion. This review revealed that total protein intake had no relationship with the risk of GDM, while animal protein increases this risk. Further larger prospective cohort studies are required to confirm our results

Investigation of the Stress–Strain and Strength Behaviors of Ice Containing Methane Hydrate

Mechanical properties and deformation behaviors of methane hydrate are important to assess the stability of gas hydrate reservoirs. In this study, using a high-pressure and low-temperature triaxial testing apparatus, the stress–strain relationship and strength of ice containing methane hydrate were studied. The results showed that the strength increased with a decrease of temperature, and the stress–strain relationship showed an elastoplastic strain-hardening behavior. When the confining pressure was less than 10 MPa, the strength increased with confining pressure. Also, it decreased with further increases of confining pressure beyond 10 MPa

Characterization of Hypolipidemic Phenol Analogues from Fermented Tea by <i>Eurotium cristatum</i>

Fuzhuan brick tea (FBT), a type of black tea, is a traditional beverage in China, especially popular among frontier ethnic groups. FBT is well-known for its health benefits, such as hypoglycemic, anti-hypertensive, anti-inflammatory, diuretic, and detoxification effects. Nevertheless, the underlying mechanisms on the molecular level are still elusive and the key compounds responsible for the health benefits are unidentified. Previous studies have mainly focused on functional studies of the water extract. However, FBT is typically cooked with butter or milk. Therefore, we hypothesized that some lipophilic components in FBT, which can be absorbed through the co-consumption of butter or milk, may play an important role in the health benefits. The present study aimed to investigate whether the liposoluble extract of FBT alleviates symptoms related to metabolic diseases and to identify the active compounds involved. By comparing the high-performance liquid chromatography (HPLC) profiles of water, milk and hexane extract, some low polarity peaks were observed in the milk and hexane extracts. Furthermore, the hexane extract treatment alleviated body weight gain, serum total cholesterol and triglyceride levels, and inhibited the accumulation of hepatic fat granules in a high-fat diet (HFD)-induced C57BL/6N mouse model. In order to identify the key functional lipophilic compounds in FBT, the hexane extract of FBT was subjected to chemical characterization. Four phenol analogs were characterized, namely, isodihydroauroglaucin (1), dihydroauroglaucin (2), tetrahydroauroglaucin (3), and flavoglaucin (4). Compounds 1 and 4 reduced the levels of total cholesterol and triglyceride in vivo. Both compounds also inhibited the high-fat diet-induced body weight gain and accumulation of fat granules in the liver of C57BL/6N mice. Isodihydroauroglaucin and flavoglaucin have therefore been identified as bioactive ingredients that contribute to the health benefits of FBT