Efficient Access to 2,3-Diarylimidazo[1,2‑<i>a</i>]pyridines via a One-Pot, Ligand-Free, Palladium-Catalyzed Three-Component Reaction under Microwave Irradiation

An expeditious one-pot, ligand-free, Pd­(OAc)₂-catalyzed, three-component reaction for the synthesis of 2,3-diarylimidazo­[1,2-<i>a</i>]­pyridines was developed under microwave irradiation. With the high availability of commercial reagents and great efficiency in expanding molecule diversity, this methodology is superior to the existing procedures for the synthesis of 2,3-diarylimidazo­[1,2-<i>a</i>]­pyridines analogues

Acid-Promoted One-Pot Synthesis of Substituted Furan and 6‑Methylpyrazin-2(1<i>H</i>)‑one Derivatives via Allene Intermediate Formed in Situ

Under the acidic conditions, substituted furans were constructed from γ-alkynyl ketones through corresponding allene intermediates in one-pot. The methodology was also tailored to a series of the Ugi reaction products for the synthesis of 6-methylpyrazin-2­(1<i>H</i>)-one derivatives. The current method offered significant advantages for the combinatorial applications of these chemical scaffolds