1 research outputs found
135-Day Interventions of Yam Dioscorin and the Dipeptide Asn-Trp (NW) To Reduce Weight Gains and Improve Impaired Glucose Tolerances in High-Fat Diet-Induced C57BL/6 Mice
The
C57BL/6J mice were fed a 135-day normal diet or a high-fat
diet (HFD) without, or concurrent with, a single yam dioscorin (80
mg/kg) or dipeptide NW (40 mg/kg) intervention every day. The final
body weights (g) of mice were 26.1 ± 1.4, 34.97 ± 2.1, 31.75
± 2.6, and 31.66 ± 3.1, respectively, for normal diet-fed,
HFD-fed, dioscorin-intervened, and NW-intervened group. The mice in
both intervened groups showed similar less weight gains and had significant
differences (<i>P</i> < 0.05) compared to those in the
HFD group under the same cumulative HFD intakes. The blood biochemical
index of mice with dioscorin interventions showed significantly lower
contents in total cholesterol and low-density lipoprotein, and NW
interventions showed significantly lower total triglyceride contents
compared to those of the HFD group (<i>P</i> < 0.05).
Both intervened mice exhibited similar reductions in total visceral
lipid contents and have significant differences compared to those
of the HFD group (<i>P</i> < 0.05). The dioscorin intervention
was better than NW interventions in lowering blood glucose levels
by oral glucose tolerance tests and both showed significant differences
(<i>P</i> < 0.05) compared to those in the HFD group.
Yam dioscorin or dipeptide NW will potentially be used for preventive
functional foods of less body weight gains and impaired glucose tolerance
controls, which require further clinical trial investigations