19 research outputs found
Distribution of FITC-labeled PNIPAM nanoparticles after intravitreous administration over a day.
<p>Localization of fluorescence in the posterior segments of the eye at various time points (2, 4 and 24 hours) was observed (A) and quantified (B). Quantification of the normalized fluorescence intensity at various locations (TB: Trabecular Meshwork; RA: Retina; ON: Optic Nerve) at various time points (C).</p
Evaluation of retinal tissue morphology following intravitreal injection.
<p>Representative H&E stained retinal tissues were shown here (A). The thickness of the retinal tissue was also calculated and then compared (B). Data are mean ± standard deviation. Significance of PLLA, PS, HA, PNIPAM vs. BSS control; * p<0.05.</p
The accumulation of CD11b+ inflammatory cells in the trabecular meshwork.
<p>The representative immunohistochemically stained images showed the accumulation of CD11b+ inflammatory cells (labeled green; DAPI staining to locate cell nucleus) in the trabecular meshwork following particle injection (A). The extent of CD11b+ cell accumulation in the trabecular meshwork was quantified (B). Data are mean ± standard deviation. Significance of PLLA, PS, HA, PNIPAM vs. BSS control; * p<0.05 Correlation between CD11b+ inflammatory cells and average IOP changes in different test groups was also determined (C).</p
Histological assessment of corneal and iris tissue after intravitreous implantation.
<p>The representative H&E images of the cornea (A) and iris (B) tissue were shown here. Based on H&E staining images, the influence of particle property on the thickness of the corneal (C) and iris (D) thickness were quantified. Data are mean ± standard deviation. Significance of PLLA, PS, HA, PNIPAM vs. BSS control; * p<0.05.</p
Physical properties of nanoparticles used for intravitreous implantation.
<p>Physical properties of nanoparticles used for intravitreous implantation.</p
Additional file 1: Table S1. of Aberrant GSTP1 promoter methylation is associated with increased risk and advanced stage of breast cancer: a meta-analysis of 19 case-control studies
MOOSE checklist in current meta-analysis. (DOC 73 kb
Holmium Laser Enucleation versus Transurethral Resection in Patients with Benign Prostate Hyperplasia: An Updated Systematic Review with Meta-Analysis and Trial Sequential Analysis
<div><p>Background</p><p>Holmium laser enucleation (HoLEP) in surgical treatment of benign prostate hyperplasia (BPH) potentially offers advantages over transurethral resection of the prostate (TURP).</p><p>Methods</p><p>Published randomized controlled trials (RCTs) were identified from PubMed, EMBASE, Science Citation Index, and the Cochrane Library up to October 10, 2013 (updated on February 5, 2014). After methodological quality assessment and data extraction, meta-analysis was performed using STATA 12.0 and Trial Sequential Analysis (TSA) 0.9 software.</p><p>Results</p><p>Fifteen studies including 8 RCTs involving 855 patients met the criteria. The results of meta-analysis showed that: a) efficacy indicators: there was no significant difference in quality of life between the two groups (P>0.05), but compared with the TURP group, Qmax was better at 3 months and 12 months, PVR was less at 6, 12 months, and IPSS was lower at 12 months in the HoLEP, b) safety indicators: compared with the TURP, HoLEP had less blood transfusion (RR 0.17, 95% CI 0.06 to 0.47), but there was no significant difference in early and late postoperative complications (P>0.05), and c) perioperative indicators: HoLEP was associated with longer operation time (WMD 14.19 min, 95% CI 6.30 to 22.08 min), shorter catheterization time (WMD −19.97 h, 95% CI −24.24 to −15.70 h) and hospital stay (WMD −25.25 h, 95% CI −29.81 to −20.68 h).</p><p>Conclusions</p><p>In conventional meta-analyses, there is no clinically relevant difference in early and late postoperative complications between the two techniques, but HoLEP is preferable due to advantage in the curative effect, less blood transfusion rate, shorter catheterization duration time and hospital stay. However, trial sequential analysis does not allow us to draw any solid conclusion in overall clinical benefit comparison between the two approaches. Further large, well-designed, multicentre/international RCTs with long-term data and the comparison between the two approaches remain open.</p></div
Forest plot for intraoperative complications.
<p>RR = relative risk; CI = confidence interval.</p
Characteristics of the included randomized controlled trials (RCTs).
<p>IPSS = International Prostate Symptom Score; QoL = quality of life; Qmax = maximum flow rate; PVR = postvoid residual volume; IIEF = International Index of Erectile Function; NA = not available.</p
Forest plot for late postoperative complications.
<p>RR = relative risk; CI = confidence interval.</p