Significant correlation of rCBF with behavioral freezing scores in the left and right hemispheres (L/R).

<p>Arrows (↑, ↓) indicate a positive or negative correlation of rCBF with the behavioral freezing score. Areas significant after correction for multiple comparisons are marked with an *p<0.05.</p

Open Field.

<p>A) 5-HTT KO mice show significantly decreased distance traveled throughout the arena in a novel open field. This is seen during the first 3 minutes of the test. B) KO mice show a non significant increase in latency to enter center zone C) There was no significant genotypic differences in number of entries into the center zone D) There was no significant genotypic difference in time spent in the center zone. Error bars represent standard error of the mean.</p

Factorial analysis examining the effect of genotype, conditioning or the interaction.

<p>Depicted are select coronal slices (anterior-posterior coordinates relative to bregma) of the template brain. Colored overlays show statistically significant effects of genotype or conditioning or their interaction, but do not reflect the direction of the effect. Abbreviations are from Franklin and Paxinos mouse atlas <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0023869#pone.0023869-Franklin1" target="_blank">[67]</a>: BL (basolateral amygdaloid nucleus), BM (basomedial amygdaloid nucleus), Ce (central amygdala), I (insular cortex), La (lateral amygdaloid nucleus), M1 (primary motor cortex), M2 (secondary motor cortex), MO (medial orbital cortex), PrL (prelimbic cortex), RS (retrosplenial cortex). Mouse brain atlas figures were reproduced from the mouse brain atlas <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0023869#pone.0023869-Franklin1" target="_blank">[67]</a> with modification and with permission from Elsevier.</p

Marble Burying.

<p>5-HTT KO mice compared to WT mice buried significantly less marbles placed in a novel cage; *p<0.001. Error bars represent standard error of the mean.</p