New-type of Multi-purpose Standard Radon Chamber in South Korea

Radon is an inert and a radioactive gas which is colorless, tasteless and odorless. As the radon decay proceeds, and if DNA damage continues beyond repair capacity of cells in the human body, it can cause severe health problems such as lung cancer in the long-term. There is a tendency that those countries where legal restriction on radon is strict, various studies related to radon are under way. In South Korea, radon has been regulated under recommendation level. Even though there are about 3 standard radon chambers in Korea, they have not been in an active use because of lack of demand. Also, most of them are specialized in calibration of radon detectors only. Recently, Korean government started giving some attention to radon issue and supporting radon research fields. Thus, this study was carried out to develop a new type of radon chamber for multi-purpose such as 1) radon emission rate from natural and artificial radon sources; 2) calibration of radon detectors; 3) evaluation of radon mitigation efficiency. Keywords: Radon, Radon Chamber, Indoor Air Quality, Chamber Desig

Effects of Aerobic Exercise Intensity on Post-exercise Blood Pressure and Cardiovascular Function in Prehypertensive Men in Their 30s

PURPOSE Blood pressure (BP) in hypertensive individuals is reduced by the accumulation of post-exercise hypotension (PEH) induced by a long period of training. This study aimed to investigate the effects of intensity of two different aerobic exercises with identical energy expenditure on post-exercise blood pressure and cardiovascular function in prehypertensive men. METHODS Eleven prehypertensive men in their 30s participated in two trials repeatedly. In the first trial, the exercise was moderate in intensity and continuous (MICE) with 70% of VO2max, and the exercise in the second trial was high-intensity interval exercise (HIIE) with 50% and 90% of VO2max. Each exercise was performed for 30 min, and the variables related to BP and cardiovascular function were measured at certain times for 1 hr during the recovery phase. RESULTS Our main findings are as follows: (1) Systolic blood pressure was significantly lower at 30 and 45 min of recovery time than the baseline in the HIIE trial, and systolic blood pressure was significantly lower in the HIIE trial than the MICE trial at 10, 15, and 30 min of recovery time. (2) The rate pressure product was significantly higher in the HIIE trial than the MICE trial at 15, 30, 45, and 60 min of recovery time. (3) The heart rate was significantly higher in the HIIE trial than the MICE trial at 15, 30, 45, and 60 min of recovery time. (4) Stroke volume was significantly lower in the HIIE trial than the MICE trial at 30 min of recovery time. (5) Cardiac output was significantly higher in the HIIE trial than the MICE trial at 15 min of recovery phase. (6) Total vascular conductance was significantly higher in the HIIE trial than the MICE trial at 15 and 30 min of recovery phase. (7) Total peripheral resistance was significantly lower in the HIIE trial than the MICE trial at 15 and 30 min of recovery phase. CONCLUSIONS The HIIE shows a higher cardiovascular stress than MICE; however, HIIE contributes to the augmentation of PEH and improvement of cardiovascular function. Therefore, HIIE rather than MICE should be suggested in BP control and enhancement of cardiovascular function in prehypertensive males

An Electrophilic Deguelin Analogue Inhibits STAT3 Signaling in H-Ras-Transformed Human Mammary Epithelial Cells: The Cysteine 259 Residue as a Potential Target

Signal transducer and activator of transcription 3 (STAT3) is a point of convergence for numerous oncogenic signals that are often constitutively activated in many cancerous or transformed cells and some stromal cells in the tumor microenvironment. Persistent STAT3 activation in malignant cells stimulates proliferation, survival, angiogenesis, invasion, and tumor-promoting inflammation. STAT3 undergoes activation through phosphorylation on tyrosine 705, which facilitates its dimerization. Dimeric STAT3 translocates to the nucleus, where it regulates the transcription of genes involved in cell proliferation, survival, etc. In the present study, a synthetic deguelin analogue SH48, discovered by virtual screening, inhibited the phosphorylation, nuclear translocation, and transcriptional activity of STAT3 in H-ras transformed human mammary epithelial MCF-10A cells (MCF10A-ras). We speculated that SH48 bearing an alpha,beta-unsaturated carbonyl group could interact with a thiol residue of STAT3, thereby inactivating this transcription factor. Non-electrophilic analogues of SH48 failed to inhibit STAT3 activation, lending support to the above supposition. By utilizing a biotinylated SH48, we were able to demonstrate the complex formation between SH48 and STAT3. SH48 treatment to MCF10A-ras cells induced autophagy, which was verified by staining with a fluorescent acidotropic probe, LysoTracker Red, as well as upregulating the expression of LC3II and p62. In conclusion, the electrophilic analogue of deguelin interacts with STAT3 and inhibits its activation in MCF10A-ras cells, which may account for its induction of autophagic death.

Enhancement on Radon Adsorption Property of GAC using Nano-size Carbon Colloids

Granular activated carbon (GAC) is well-known as an efficient adsorbent against a number of gaseous pollutants. Radon is one of those pollutants, and radon has been classified as the second leading cause of lung cancer in USA. This study was to enhance the radon removal efficiency with applying nano-technology. Nano-size carbon colloids (NCC) was produced through electrolysis which is simple and cheap. NCC was used for impregnation with activated carbon. Surface areas of both NCC-treated and non-treated activated carbon did not show a significant difference. However, the results of radon removal efficiency show that impregnated carbon with NCC could capture about 1.3 ~ 2 times of more radon gas compared to non-treated activated carbon. It is assumed that nano-size carbon colloids might have filled up meso-pores, and meso-pores turned into micro-pores eventually. Because meso-pores initially accounted for large portion of whole pores, more radon could be captured to NCC-impregnated activated carbon. Keywords: Radon, Nano-Size Carbon Collid, Activated Carbo