13 research outputs found

    Association between Air Pollution and Suicide in South Korea: A Nationwide Study

    No full text
    <div><p>Suggestive associations of suicide with air pollutant concentrations have been reported. Recognizing regional and temporal variability of pollutant concentrations and of suicide, we undertook a detailed meta-analysis of completed suicides in relation to 5 major pollutants over 6 years in the 16 administrative regions of the Republic of Korea, while also controlling for other established influences on suicide rates. Of the 5 major pollutants examined, ozone concentrations had a powerful association with suicide rate, extending back to 4 weeks. Over the range of 2 standard deviations (SD) around the annual mean ozone concentration, the adjusted suicide rate increased by an estimated 7.8% of the annual mean rate. Particulate matter pollution also had a significant effect, strongest with a 4-week lag, equivalent to 3.6% of the annual mean rate over the same 2 SD range that approximated the half of annual observed range. These results strongly suggest deleterious effects of ozone and particulate matter pollution on the major public health problem of suicide.</p></div

    Cost-effectiveness of vortioxetine <i>versus</i> venlafaxine (extended release) in the treatment of major depressive disorder in South Korea

    No full text
    <div><p>ABSTRACT</p><p><b><i>Objective</i></b>: To assess the cost-effectiveness of vortioxetine <i>versus</i> venlafaxine XR (extended-release) in major depressive disorder (MDD) patients in South Korea.</p><p><b><i>Methods</i></b>: A 1-year cost-effectiveness analysis from a limited societal perspective was performed using a combined model consisting of a decision-tree and a Markov model. Patients entered the model when initiating or switching antidepressant treatment following inadequate response to previous treatment. Remission, relapse and recovery were the main health states.</p><p><b><i>Results</i></b>: Vortioxetine dominated venlafaxine XR, with quality-adjusted life year (QALY) gains of 0.0131 and cost savings of KRW 623,229/year [US$530/year] from a limited societal perspective. Safety contributed more than efficacy to the incremental QALY gains. More patients were in recovery after initial treatment and after 1 year with vortioxetine (31%, 40%) compared to venlafaxine XR (23%, 36%). Vortioxetine remained dominant in 98% of probabilistic simulations.</p><p><b><i>Conclusion</i></b>: Vortioxetine dominated venlafaxine XR in South Korea and is a relevant treatment option for MDD patients initiating or switching therapy.</p></div

    Associations of Pollutants with Averaged Weekly Suicide Rate per 10 million Persons from Lag 0 to Lag 4.

    No full text
    <p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0117929#pone.0117929.t001" target="_blank">Table 1</a>. are results of meta-analyses of regional data in South Korea from 2006 through 2011.</p><p>Abbreviations: S.E., Standard Error; SD, Standard Deviation; CI, Confidence Interval; PM-10, Particulate Matter (particulates with size of 10 μm in diameter or smaller).</p><p><sup>a.</sup> Increased weekly suicides per 10 million persons when the level of air pollution increases by 1 unit.</p><p><sup>b.</sup> Calculated by multiplication of beta, 2 SD range of national level of air pollution and inverse number of national weekly suicide rate per 10 million persons.</p><p><sup>c.</sup> Corrected by Bonferroni’s method for the tests of the number of time lags.</p><p><sup>d.</sup> I-square heterogeneity test and Cochran’s Q test were employed for testing the presence of statistical heterogeneity in meta-analyses.</p><p>Associations of Pollutants with Averaged Weekly Suicide Rate per 10 million Persons from Lag 0 to Lag 4.</p

    Suicide Increase Associated with Air Pollution Increase According To Weeks Prior to suicide.

    No full text
    <p>(<i>A</i>) Ozone; (<i>B</i>) Particulate matter; (<i>C</i>) Nitrogen dioxide; (<i>D</i>) Carbon monoxide; (<i>E</i>) Sulfur dioxide. *Corrected <i>P</i>< 0.05, **corrected <i>P</i>< 0.01, ***corrected <i>P</i>< 0.001, ****corrected <i>P</i>< 0.0001. Percentage suicide increase was calculated by multiplication of beta, range of pollutant concentration from-1SD to +1SD relative to the annual mean value (2 SD range) and inverse number of national weekly suicide rate per 10 million persons.</p
    corecore