"Voices and Their Dis/Content in Taiwan Documentary" and "From Social Activism to Eco Activism: Current Situation of Taiwan Documentary"

This video features two lectures on documentary film in Taiwan. First is "Voices and Their Dis/Content in Taiwan Documentary" by Professor Guo-Juin Hong of Duke University. Second is "From Social Activism to Eco Activism: Current Situation of Taiwan Documentary" by Professor Ru-Shou Robert Chen of National Chengchi University

Panel discussion with Ho Chao-ti 賀照緹

A discussion with filmmaker Ho Chao-ti about her film, Sock’n Roll 台灣黑狗兄 (2013), a documentary about the predicament faced by Taiwan’s small enterprises through the story of a sock town in rapid decline

Panel discussion with Ke Chin-Yuan 柯金源

A discussion with filmmaker Ke Chin-Yuan about his film, "Ebb and Flow" 退潮 (2010), a documentary about the traditional lifestyle and natural environment of the fishermen living in the middle-west coast of Taiwan

Panel discussion with Ke Chin-Yuan 柯金源

A discussion with filmmaker Ke Chin-Yuan about his film, "Ebb and Flow" 退潮 (2010), a documentary about the traditional lifestyle and natural environment of the fishermen living in the middle-west coast of Taiwan

Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease

White matter (WM) atrophy is a significant feature of Huntington disease (HD), although its aetiology and early pathological manifestations remain poorly defined. In this study, we aimed to characterize WM-related features in the transgenic YAC128 and BACHD models of HD. Using diffusion tensor magnetic resonance imaging (DT-MRI), we demonstrate that microstructural WMabnormalities occur from an early age in YAC128 mice. Similarly, electron microscopy analysis of myelinated fibres of the corpus callosum indicated that myelin sheaths are thinner in YAC128 mice as early as 1.5 months of age, well before any neuronal loss can be detected. Transcript levels of myelin-related genes in striatal and cortical tissues were significantly lower in YAC128 mice from 2 weeks of age, and these findings were replicated in differentiated primary oligodendrocytes from YAC128 mice, suggesting a possible mechanistic explanation for the observed structural deficits. Concordant with these observations, we demonstrate reduced expression of myelin-related genes at 3 months of age and WMmicrostructural abnormalities using DT-MRI at 12 months of age in the BACHD rats. These findings indicate thatWM deficits in HD are an early phenotype associated with cell-intrinsic effects of mutant huntingtin on myelin-related transcripts in oligodendrocytes, and raise the possibility thatWMabnormalities may be an early contributing factor to the pathogenesis of HD