A versatile design for resonant guided-wave parametric down-conversion sources for quantum repeaters

Quantum repeaters - fundamental building blocks for long-distance quantum communication - are based on the interaction between photons and quantum memories. The photons must fulfil stringent requirements on central frequency, spectral bandwidth and purity in order for this interaction to be efficient. We present a design scheme for monolithically integrated resonant photon-pair sources based on parametric down-conversion in nonlinear waveguides, which facilitate the generation of such photons. We investigate the impact of different design parameters on the performance of our source. The generated photon spectral bandwidths can be varied between several tens of MHz up to around $1\,$GHz, facilitating an efficient coupling to different memories. The central frequency of the generated photons can be coarsely tuned by adjusting the pump frequency, poling period and sample temperature and we identify stability requirements on the pump laser and sample temperature that can be readily fulfilled with off-the-shelve components. We find that our source is capable of generating high-purity photons over a wide range of photon bandwidths. Finally, the PDC emission can be frequency fine-tuned over several GHz by simultaneously adjusting the sample temperature and pump frequency. We conclude our study with demonstrating the adaptability of our source to different quantum memories.Comment: 10 pages, 8 figure

Cultivation Theory And Violence In Media: Correlations And Observations

Cultivation Theory represents the idea that people’s perceptions of the real world are unconsciously influenced by their consumption of media. As technology has improved and increased, so too has the amount of information various platforms are able to spread. However, there is an imbalance between the amount of violence depicted in media and the amount that occurs in real life, leading to unrealistic perceptions of a mean world. Most cultivation research is not experimental. For my thesis, I decided to conduct an experiment of my own using YouTube clips emphasizing violent or fearful content, using a variety of established practices and questions, as well as some of my own. Although result were not conclusive, a few patterns consistent with Cultivation Theory were observed in this online context

Case study of improving the speech intelligibility of children with Down syndrome using pacing boards

textThe present study was designed to answer the following questions: (a) Can a child with Down syndrome (DS) increase speech intelligibility using a pacing board through a modified Core Vocabulary Approach (CVA)? (b) What are the effects of the pacing board as an intervention tool on the speech skills of children with DS? (c) What is a valid measurement of improved speech intelligibility? In this case study, the pacing board was used as an intervention tool in conjunction with a modified CVA with one child with DS to examine whether a child with limited speech skills could increase her speech intelligibility to enhance communicative competence. Data was collected on the child’s speech production output patterns in order to provide information on the pacing board’s efficacy. Results indicated that the pacing board was an effective intervention tool for this child. Increases on various speech intelligibility metrics were evident. The child's improvements on indices examined in this study were slow but significant, relative to her previous speech and language status.Communication Sciences and Disorder

Effects of past and current crop management on leaching losses, soil microbial community composition and activity

A lysimeter experiment was conducted to investigate the effect of past and current management practices on soil microbial biomass, activity and community composition. Intact monolith lysimeters were taken from sites of the same soil type that had been under long-term organic and conventional crop management. They were subjected to the same crop rotation and managed according to best organic and conventional practices. Mineral N loss was determined in leachates and soil samples taken before the experiment and after 30 months were analysed for biological soil properties, including microbial diversity. Results indicated that leaching losses were similar for all treatments and that crop was the main influence on microbial biomass composition and size, while microbial activity was determined by management history

Structure and substrate selectivity of the 750-kDa α6β6 holoenzyme of geranyl-CoA carboxylase.

Geranyl-CoA carboxylase (GCC) is essential for the growth of Pseudomonas organisms with geranic acid as the sole carbon source. GCC has the same domain organization and shares strong sequence conservation with the related biotin-dependent carboxylases 3-methylcrotonyl-CoA carboxylase (MCC) and propionyl-CoA carboxylase (PCC). Here we report the crystal structure of the 750-kDa α6β6 holoenzyme of GCC, which is similar to MCC but strikingly different from PCC. The structures provide evidence in support of two distinct lineages of biotin-dependent acyl-CoA carboxylases, one carboxylating the α carbon of a saturated organic acid and the other carboxylating the γ carbon of an α-β unsaturated acid. Structural differences in the active site region of GCC and MCC explain their distinct substrate preferences. Especially, a glycine residue in GCC is replaced by phenylalanine in MCC, which blocks access by the larger geranyl-CoA substrate. Mutation of this residue in the two enzymes can change their substrate preferences

Inhibition of EZH2 Promotes Human Embryonic Stem Cell Differentiation into Mesoderm by Reducing H3K27me3.

Mesoderm derived from human embryonic stem cells (hESCs) is a major source of the mesenchymal stem/stromal cells (MSCs) that can differentiate into osteoblasts and chondrocytes for tissue regeneration. While significant progress has been made in understanding of molecular mechanisms of hESC differentiation into mesodermal cells, little is known about epigenetic factors controlling hESC fate toward mesoderm and MSCs. Identifying potential epigenetic factors that control hESC differentiation will undoubtedly lead to advancements in regenerative medicine. Here, we conducted an epigenome-wide analysis of hESCs and MSCs and uncovered that EZH2 was enriched in hESCs and was downregulated significantly in MSCs. The specific EZH2 inhibitor GSK126 directed hESC differentiation toward mesoderm and generated more MSCs by reducing H3K27me3. Our results provide insights into epigenetic landscapes of hESCs and MSCs and suggest that inhibiting EZH2 promotes mesodermal differentiation of hESCs