76 research outputs found
Glargine and degludec: solution behaviour of higher dose synthetic insulins
Single, double and triple doses of the synthetic insulins glargine and degludec currently used in patient therapy are characterised using macromolecular hydrodynamic techniques (dynamic light scattering and analytical ultracentrifugation) in an attempt to provide the basis for improved personalised insulin profiling in patients with diabetes. Using dynamic light scattering and sedimentation velocity in the analytical ultracentrifuge glargine was shown to be primarily dimeric under solvent conditions used in current formulations whereas degludec behaved as a dihexamer with evidence of further association of the hexamers (âmulti-hexamerisationâ). Further analysis by sedimentation equilibrium showed that degludec exhibited reversible interaction between mono- and-di-hexamer forms. Unlike glargine, degludec showed strong thermodynamic non-ideality, but this was suppressed by the addition of salt. With such large injectable doses of synthetic insulins remaining in the physiological system for extended periods of time, in some case 24â40âhours, double and triple dose insulins may impact adversely on personalised insulin profiling in patients with diabetes
The impact of a computerized decision aid on empowering pregnant women for choosing vaginal versus cesarean section delivery: study protocol for a randomized controlled trial
Growthâdifferentiationâfactor 15 levels in obese and healthy pregnancies: Relation to insulin resistance and insulin secretory function
Su2077 Body Weight in Patients With Gastroparesis: Roles of Symptoms, Caloric Intake, Physical Activity, and Body Metabolism
Impaired microvascular reactivity in gestational diabetes is associated with altered glycemic parameters
Mo1283 Effect of Dietary Fat and Food Consistency on Gastroparesis Symptoms in Patients With Gastroparesis
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