Symptoms and Self-Care in Old Age

Self-care has recently come to be recognized as the predominant form of response to illness among the general population, but little is known regarding beliefs and practices of the aged. In this study, beliefs regarding the appropriate response to 53 common symptoms were investigated and contrasted to actual responses. Various forms of self-care were seen as appropriate responses to symptoms ranging from minor to potentially serious. Preference for self-care responses appears to be related to perceived severity of symptoms and the perceived effectiveness of available self-care responses.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66474/2/10.1177_073346488600500207.pd

Evaluation of the soil moisture prediction accuracy of a space radar using simulation techniques

Image simulation techniques were employed to generate synthetic aperture radar images of a 17.7 km x 19.3 km test site located east of Lawrence, Kansas. The simulations were performed for a space SAR at an orbital altitude of 600 km, with the following sensor parameters: frequency = 4.75 GHz, polarization = HH, and angle of incidence range = 7 deg to 22 deg from nadir. Three sets of images were produced corresponding to three different spatial resolutions; 20 m x 20 m with 12 looks, 100 m x 100 m with 23 looks, and 1 km x 1 km with 1000 looks. Each set consisted of images for four different soil moisture distributions across the test site. Results indicate that, for the agricultural portion of the test site, the soil moisture in about 90% of the pixels can be predicted with an accuracy of = + or - 20% of field capacity. Among the three spatial resolutions, the 1 km x 1 km resolution gave the best results for most cases, however, for very dry soil conditions, the 100 m x 100 m resolution was slightly superior

Using Astrometry to Deblend Microlensing Events

We discuss the prospect of deblending microlensing events by observing astrometric shifts of the lensed stars. Since microlensing searches are generally performed in very crowded fields, it is expected that stars will be confusion limited rather than limited by photon statistics. By performing simulations of events in crowded fields, we find that if we assume a dark lens and that the lensed star obeys a power law luminosity function, $n(L)\propto L^{-\beta}$, over half the simulated events show a measurable astrometric shift. Our simulations included 20000 stars in a $256\times 256$ Nyquist sampled CCD frame. For $\beta=2$, we found that 58% of the events were significantly blended $(F_{\ast}/F_{tot}\leq 0.9)$, and of those, 73% had a large astrometric shift $(\geq 0.5 pixels)$. Likewise, for $\beta=3$, we found that 85% of the events were significantly blended, and that 85% of those had large shifts. Moreover, the shift is weakly correlated to the degree of blending, suggesting that it may be possible not only to detect the existence of a blend, but also to deblend events statistically using shift information.Comment: 24 pages, 7 postscript Figure

Independent study demonstrates amyloid probability score accurately indicates amyloid pathology

BACKGROUND: The amyloid probability score (APS) is the model read-out of the analytically validated mass spectrometry-based PrecivityAD PURPOSE: This study aimed to provide additional independent evidence that the pre-established APS algorithm, along with its cutoff values, discriminates between amyloid positive and negative individuals. METHODS: The diagnostic performance of the PrecivityAD test was analyzed in a cohort of 200 nonrandomly selected Australian Imaging, Biomarker & Lifestyle Flagship Study of Aging (AIBL) study participants, who were either cognitively impaired or healthy controls, and for whom a blood sample and amyloid PET imaging were available. RESULTS: In a subset of the dataset aligned with the Intended Use population (patients aged 60 and older with CDR ≥0.5), the pre-established APS algorithm predicted amyloid PET with a sensitivity of 84.9% (CI: 72.9-92.1%) and specificity of 96% (CI: 80.5-99.3%), exclusive of 13 individuals for whom the test was inconclusive. INTERPRETATION: The study shows individuals with a high APS are more likely than those with a low APS to have abnormal amounts of amyloid plaques and be on an amyloid accumulation trajectory, a dynamic and evolving process characteristic of progressive AD pathology. Exploratory data suggest APS retains its diagnostic performance in healthy individuals, supporting further screening studies in the cognitively unimpaired

Mixed Dark Matter from Axino Distribution

We study the possibility of mixed dark matter obtained through the phase space distribution of a single particle. An example is offered in the context of SUSY models with a Peccei-Quinn symmetry. Axinos in the 100 keV range can naturally have both thermal and non-thermal components. The latter one arises from the lightest neutralino decays and derelativizes at z ~ 10^4.Comment: Figures added, references fixed. Version accepted for publication on Phys. Rev. D. LaTeX. 9 pages, 3 figures, uses epsfig.st

Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution

Transmission and secretion of signals via the choroid plexus (ChP) brain barrier can modulate brain states via regulation of cerebrospinal fluid (CSF) composition. Here, we developed a platform to analyze diurnal variations in male mouse ChP and CSF. Ribosome profiling of ChP epithelial cells revealed diurnal translatome differences in metabolic machinery, secreted proteins, and barrier components. Using ChP and CSF metabolomics and blood-CSF barrier analyses, we observed diurnal changes in metabolites and cellular junctions. We then focused on transthyretin (TTR), a diurnally regulated thyroid hormone chaperone secreted by the ChP. Diurnal variation in ChP TTR depended on Bmal1 clock gene expression. We achieved real-time tracking of CSF-TTR in awake Tt