Staging of prostatic carcinoma at 1.5-T MRI: correlation of a simplified MRI exam with whole-mount radical prostatectomy specimens

To retrospectively analyze the accuracy of simplified multiparametric MRI at 1.5 T for local staging by using whole-mount-section histopathological analysis as the standard of reference.status: publishe

μ ‐Opioid activation in the midbrain during migraine allodynia – brief report II

We investigated in vivo the allodynic response of the central μ ‐opioid system during spontaneous migraine headaches, following a sustained pain threshold challenge on the trigeminal ophthalmic region. Six migraineurs were scanned during the ictal and interictal phases using positron emission tomography ( PET ) with the selective μ ‐opioid receptor ( μ OR ) radiotracer [11C]carfentanil. Females were scanned during the mid‐late follicular phase of two separate cycles. Patients showed ictal trigeminal allodynia during the thermal challenge that was concurrent and positively correlated with μ OR activation in the midbrain, extending from red nucleus to ventrolateral periaqueductal gray matter. These findings demonstrate for the first time in vivo the high μ OR activation in the migraineurs' brains in response to their allodynic experience.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107586/1/acn366.pd

μ ‐Opioid activation in the prefrontal cortex in migraine attacks – brief report I

We evaluated in vivo the μ ‐opioid system during spontaneous episodic migraine headaches. Seven patients were scanned at different phases of their migraine using positron emission tomography with the selective μ ‐opioid receptor ( μ OR ) radiotracer [11C]carfentanil. In the ictal phase, there was μ OR activation in the medial prefrontal cortex, which was strongly associated with the μ OR availability level during the interictal phase. Furthermore, μ ‐opioid binding changes showed moderate negative correlation with the combined extension and severity of the attacks. These results indicate for the first time that there is high μ OR activation in the migraineurs' brains during headache attacks in response to their pain.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107492/1/acn365.pd

μ

We evaluated in vivo the μ ‐opioid system during spontaneous episodic migraine headaches. Seven patients were scanned at different phases of their migraine using positron emission tomography with the selective μ ‐opioid receptor ( μ OR ) radiotracer [11C]carfentanil. In the ictal phase, there was μ OR activation in the medial prefrontal cortex, which was strongly associated with the μ OR availability level during the interictal phase. Furthermore, μ ‐opioid binding changes showed moderate negative correlation with the combined extension and severity of the attacks. These results indicate for the first time that there is high μ OR activation in the migraineurs' brains during headache attacks in response to their pain.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107492/1/acn365.pd