Nurturing America\u27s Growth in the Global Marketplace Through Talent Development: An Interim Report on the Evaluation of Generations II and III of WIRED

This is the first report from the evaluation of Generations II and III of the Workforce Innovations in Regional Economic Development Initiative... This interim report presents baseline information from all 26 regions. It reflects the status of regional activities as of the summer of 2008, when many regions were in the initial stage of implementation. Thus, the report focuses on the development of partnerships, governance arrangements, and the design of decision-making processes. In early 2006, ETA announced the initial recipients of grants to promote regional collaboration of a wide range of public and private organizations with the goal of transforming their regional approaches for addressing economic challenges. The grants were intended to bring together diverse regional organizations in order to work towards economic stability and workforce growth. Thirteen additional regions were competitively selected for grants in January 2007, followed by a final 13 in June 2007. These grantees are collectively referred to as Generations II and III

Predictors of suicidal ideation, suicide attempts, and self-harm without lethal intent in a community corrections sample

Purpose Little published research data exist about suicidal ideation and self-harm behavior in community corrections and we seek to fill this void.Aims To examine the effects of drug dependence, depression, anxiety, psychopathy, fracture, and child trauma on suicidal ideation, suicide attempts, and self-harm without lethal intent in community corrections.Methods The Semi-Structured Assessment for the Genetics of Alcoholism Revised (SSAGA II) and the screening version of the Hare Psychopathy Checklist (PCL:SV) were administered. Separate binary logistic regression analyses were used to predict lifetime suicidal ideation, suicide attempt, and self-harm behavior.Results Prevalences of suicidal ideation, suicide attempt, and self-harm without lethal intent were 41%, 19%, and 14%. Suicidal ideation was predicted by drug dependence, elevated PCL:SV Factor 2 score, and Caucasian race. Suicidal ideation and attempt were both predicted by fractures, depression, and child trauma. Self-harm was predicted by fractures, panic, PCL:SV score, and child trauma.Conclusions Child trauma and multiple fractures are potent predictors for suicidal ideation, suicide attempts, and self-harm without lethal intent in this community corrections sample. Depression predicted suicidal ideation and attempts, while panic predicted self-harm without lethal intent. Psychopathy was also an important predictor of suicidal ideation and self-harm behaviors without lethal intent.

The Relationship of Deiodinase 1 Genotype and Thyroid Function to Lifetime History of Major Depression in Three Independent Populations

Major depression (MD) is often associated with disturbances of the hypothalamic/pituitary/thyroid (HPT) axis. Unfortunately, whether this association is secondary to common underlying genetic variation or whether the MD‐associated disturbances in HPT function are chronic or state‐dependent is unknown. To examine these questions, we genotyped 12 single nucleotide polymorphisms identified in previous genome wide association analyses of thyroid function in DNA contributed by 1,555 subjects from three longitudinal ethnically diverse studies that are well‐characterized for lifetime MD and thyroid function. We then examined associations between genetic variants and key outcomes of thyroid stimulating hormone, free thyroxine (FT4) and depression. We confirmed prior findings that two variants in deiodinase 1 (DIO1), including a variant in the 3′UTR of DIO1 (rs11206244), were associated with altered FT4 levels in both White and African American subjects. We also found that rs11206244 genotype was associated with lifetime MD in White female subjects, in particular those from high‐risk cohorts. However, we found no association of current FT4 levels with lifetime MD in either ethnic group. We conclude that genetic variation influencing thyroid function is a risk factor for MD. Given the evidence from prior studies, further investigations of role of HPT variation in etiology and treatment of MD are indicated.This is the peer-reviewed version of the following article: Philibert, Robert A., Steven RH Beach, Tracy D. Gunter, Alexandre A. Todorov, Gene H. Brody, Meeshanthini Vijayendran, Lilly Elliott, Nancy Hollenbeck, Daniel Russell, and Carolyn Cutrona. "The relationship of deiodinase 1 genotype and thyroid function to lifetime history of major depression in three independent populations." American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156, no. 5 (2011): 593-599, which has been published in final form at DOI: 10.1002%2Fajmg.b.31200. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Posted with permission.</p