27 research outputs found
EFFECT OF MODE OF LOAD CARRIAGE ON POSTURAL SWAY
- Publication venue
- International Society of Biomechanics in Sports (ISBS)
- Publication date
- 03/10/2014
- Field of study
People commonly carry external loads for sport and recreational purposes; recently the safety of such practice has come into question. The purpose of this study was to evaluate balance under different load carriage conditions. Fifteen college-age individuals completed three blocks of quiet standing trials: unloaded, wearing a backpack, and wearing a shoulder bag. A-P sway amplitude was greater under the backpack condition than the unloaded condition (P = 0.013); however, A-P sway amplitude did not differ between the backpack and shoulder bag condition, nor did it differ between the unloaded and shoulder bag condition. M-L sway amplitude, sway area, peak sway velocity, and stance width were not dependent on load condition. This evidence suggests a backpack and shoulder bag are equally safe means of load carriage in college-age individuals
Vancomycin AUC/MIC ratio and 30-day mortality in patients with Staphylococcus aureus bacteremia
- Author
- Antibiotic Expert Group
- Benjamin P. Howden
- Brown
- Charles
- Charlson
- Clinical and Laboratory Standards Institute
- Cockcroft
- Craig
- Craig
- del Mar Fernandez de Gatta Garcia
- Deresinski
- Drusano
- Gould
- Hidayat
- Holland
- Holmes
- Holmes
- Howden
- Hsu
- J. Owen Robinson
- Jeffres
- John D. Turnidge
- Knaus
- Kullar
- Le Gall
- Lodise
- Lodise
- Mathew
- Mathew
- Matthew V. N. O'Sullivan
- McGregor
- Mohr
- Moise
- Moise
- Moise-Broder
- Musta
- Natasha E. Holmes
- Neuner
- Paterson
- Paul D. R. Johnson
- Prakash
- Price
- Rehm
- Rose
- Rule
- Rybak
- Rybak
- Sader
- Sakoulas
- Sally A. Roberts
- Sanchia J. C. Warren
- Soriano
- Tara L. Anderson
- Tony M. Korman
- van Hal
- van Hal
- Wei Gao
- Wendy J. Munckhof
- Publication venue
- 'American Society for Microbiology'
- Publication date
- 01/01/2013
- Field of study
A ratio of the vancomycin area under the concentration-time curve to the MIC (AUC/MIC) of ≥ 400 has been associated with clinical success when treating Staphylococcus aureus pneumonia, and this target was recommended by recently published vancomycin therapeutic monitoring consensus guidelines for treating all serious S. aureus infections. Here, vancomycin serum trough levels and vancomycin AUC/MIC were evaluated in a "real-world" context by following a cohort of 182 patients with S. aureus bacteremia (SAB) and analyzing these parameters within the critical first 96 h of vancomycin therapy. The median vancomycin trough level at this time point was 19.5 mg/liter. There was a significant difference in vancomycin AUC/MIC when using broth microdilution (BMD) compared with Etest MIC (medians of 436.1 and 271.5, respectively; P373, derived using classification and regression tree analysis, was associated with reduced mortality (P=0.043) and remained significant in a multivariable model. This study demonstrated that we obtained vancomycin trough levels in the target therapeutic range early during the course of therapy and that obtaining a higher vancomycin AUC/MIC (in this case, >373) within 96 h was associated with reduced mortality. The MIC test method has a significant impact on vancomycin AUC/MIC estimation. Clinicians should be aware that the current target AUC/MIC of ≥400 was derived using the reference BMD method, so adjustments to this target need to be made when calculating AUC/MIC ratio using other MIC testing methods. Copyrigh
Organising health care services for people with an acquired brain injury: an overview of systematic reviews and randomised controlled trials
- Author
- A Forster
- A Moseley
- Anne E Holland
- Australian Bureau of Statistics
- Australian Institute of Health and Welfare
- B Indredavik
- C Cramer
- C Parker
- C Ytterberg
- D Schull
- D Sulch
- DC Strasser
- Denise O’Connor
- DT Wade
- DT Wade
- Emma Tavender
- ERABI
- Fary Khan
- G Ellis
- G Ross
- GRADE Working Group
- H Andersen
- I Odderson
- J Kwan
- JA Falconer
- JA Hinchey
- K Allen
- K Bell
- K Bell
- K Lakshminarayan
- K Laver
- Kate Laver
- KR Bell
- L Kalra
- L Turner-Stokes
- L vanHolmqvist
- LE Trexler
- M Dirks
- M Faul
- Natasha A Lannin
- O Ghaffar
- P Fearon
- Peter Bragge
- Peter Hunter
- PK Patterson
- Robert Teasell
- Russell Gruen
- S Downs
- S Middleton
- S Stein
- SC Johnston
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Act now against new NHS competition regulations: an open letter to the BMA and the Academy of Medical Royal Colleges calls on them to make a joint public statement of opposition to the amended section 75 regulations.
- Author
- Anson James
- Applebee Jackie
- Arnold Natasha
- Awsare Ninaad
- Bambra Clare
- Banks Ian
- Bareford David
- Basarab Adriana
- Beadsworth Mike
- Beer Naomi
- Bell David
- Bell David
- Bennett-Richards Phillip
- Bhatti Osman
- Boomla Kambiz
- Bossano David
- Bostock David
- Boswell John P
- Bratty Catherine
- Brearey Steve
- Brown Kirsten
- Brown Raymond
- Buhrs Ernst
- Burgess-Allen Jilla
- Bury Bob
- Buttivant Helen
- Caan Woody
- Cabot Kate
- Camilleri-Ferrante Corinne
- Carter Lucy
- Chamberlain MA
- Chandy Rajiv
- Cheeroth Sheila
- Clark Leon
- Clarke Aileen
- Clarke Edward
- Coates Jonathan
- Cole Jim
- Coleman Michel
- Colvin Deborah
- Cook Derek
- Cripwell Michael
- Crome Peter
- Cullinan Paul
- Currie Jonny
- Daley Helen
- Danby Jude
- Darling Jonathan
- Davies David
- Davies Gerry
- Davis Jacky
- Deveson Pete
- Dickinson Jane
- Dickson Harriet
- Domizio Paola
- Duncan John AT
- Edwards Mark
- Edwards Martin
- Ehrhardt Peter
- Eisner Maggie
- Erskine Jonathan
- Etherington Robert
- Evans David
- Evans-Jones John
- Farrelly George
- Feder Gene
- Feehally John
- Fell Henry
- Fellows Griffith
- Fielding Richard
- Finer Nick
- Finer Sarah
- Fisher Brian
- Fitchett Mike
- Fitzgerald Richard
- Fleming Peter
- Fleming Peter
- Fluxman Jonathan
- Folb Jonathan
- Folb Jonathan
- Ford Amy
- Ford Steven
- Franks Andrea
- Freud Kathy McAdam
- Gawler Jeff
- Gibbs John
- Gill Alison
- Godfrey Peter
- Goodger V
- Gore Jonathan
- Gould Derek A
- Greenhalgh Trisha
- Griffiths Alun
- Grunewald Richard
- Gurling Hugh
- Hall Alyson
- Hall Peter
- Hamlyn Adrian N
- Hawkins David
- Highton Clare
- Hirst Julie
- Hobson Esther
- Holland Walter
- Holt Kim
- Holt Victoria J
- Hopkinson Nicholas
- Hotchkiss Julie
- Hughes Richard
- Ingrams Grant
- Ireland Maggie
- Irvine Louise
- Irving William L
- Jacobson Bobbie
- Jeffreys Anne
- Jenner David
- Jenner David
- Johnson Guy
- Johnston Sally
- Johnstone Chris
- Jones Anna
- Jones Coral
- Jones Phil
- Kendall Bryony
- Kinmonth Ann-Louise
- Kirwin Simon
- Klonin Hilary
- Knight David
- Koperski M
- Kraemer Sebastian
- Landers Aileen
- Lau Alice
- Lawrence David
- Lee Alan
- Lefevre Dianne
- Leigh Martha
- Lewis David
- Lewis David
- Lewis Geoffrey
- Livingstone Anna
- Lockwood Kate
- Logan Jane
- Logan Mary
- Logan Stuart
- Lowes Simon
- Lyttelton Laura
- Ma Richard
- Macfarlane Alison
- Macgibbon Robert
- Macklon AF
- Maclennan Iain
- Macpherson Jamie
- Main John
- Mann Nick
- Marlowe Gary
- Marmot Saul
- Martin P
- Maryon-Davis Alan
- Mason Rebecca
- McCartney Margaret
- McCoy David
- McEewen J
- McElderry Elisabeth
- McKee Martin
- McPherson Klim
- Michael Benedict
- Middleton John
- Miller Jo
- Mindell Jennifer
- Mitchel Sarah
- Mitchison Sally
- Moore Robert
- Morrison Richard
- Mullen Paul
- Munday Pat
- Murphy E
- Newell Jo
- Nixon Jonathan
- Noor R
- Nsutebu Emmanuel
- Ormerod Julian
- Ormerod Oliver
- Paintin David
- Patel Anita
- Paul Ashish
- Peedell Clive
- Pollock Alyson
- Pride Neil
- Puntis John
- Rainbow Daniel
- Rawaf Salman
- Reeve Joanne
- Reissman Gerard
- Ross Wendy
- Rossiter Brian
- Salim Asad
- Savage Wendy
- Sayer Mel
- Schweiger Martin
- Scott Brian
- Scott-Samuel Alex
- Sharma Ajay
- Sharp Deborah J
- Sharvill John
- Sikorski Jim
- Silverman Ruth
- Singer Ron
- Singh G
- Singh Surinder
- Smailes Alison
- Smyth Alan
- Souza Richard de
- Stevenson Nicola
- Stobbart Kate
- Suckling Ruth
- Tallis Ray
- Tebboth Louise
- Timmis Alison
- Timms Philip
- Tomlinson Jonathon
- Tomlinson Laurie
- Tomson D
- Tomson Mike
- Torabi Payam
- Tulloch Alex
- Turner Gill
- Venning Helen
- Walker Jonathan
- Waterston Tony
- Wesby Barbara
- West Andrew
- West Robert
- West Robert
- Whincup Peter
- Wolfe Ingrid
- Wortley Pam
- Wrigley David
- Young Gail
- Young Jane
- Yudkin John S
- Zinkin Pam
- Publication venue
- 'BMJ'
- Publication date
- 20/03/2013
- Field of study
American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood-Onset Systemic Lupus Erythematosus
- Author
- Abud Carlos
- Abulaban Khalid
- Adib Navid
- Aggarwal Amita
- Ailioaie Constantin
- Akikusa Jonathan
- Al Abrawi Safiya
- Al-Abadi Eslam
- Al-Mayouf Sulaiman
- Alegria Mauricio
- Alekseeva Ekaterina
- Ang Elizabeth
- Appenzeller Simone
- Ardoin Stacy P
- Arkachaisri Thaschawee
- Asiri Abdurhman
- Avcin Tadej
- Aviel Yonatan Butbul
- Aydin Pinar Ozge Avar
- Baildam Eileen
- Barbar-Smiley Fatima
- Battagliotti Cristina
- Beresford Michael W
- Bica Blanca
- Binstadt Bryce
- Bohnsack John
- Boiu Sorina
- Bolt Isabel
- Boneparth Alexis
- Boros Christina
- Borzutzky Arturo
- Boteanu Alina-Lucica
- Brown Diane
- Brunner Hermine I
- Brusco Maria Isabel
- Burgos-Vargas Ruben
- Cabral David
- Calvo Inmaculada
- Cameto Juan
- Campos Leonardo
- Campos Lucia M Arruda
- Carreno-Manjarrez Roberto
- Cavalcanti Andre
- Chedeville Gaelle
- Chira Peter
- Cifuentes Mayra
- Cimaz Rolando
- Collaborative Pediat Rheumatology
- Concannon Anthony
- Conde Marta
- Cron Randy
- Cuttica Ruben
- Dans Leonia
- de Almeida Rozana Gasparello
- de Carvalho Luciana Martins
- De Cunto Carmen
- Dedeoglu Fatma
- del Valle Enid
- do Prado Rogerio
- Dolezalova Pavla
- Donner-Maliki Amanda
- Dressler Frank
- Eberhard Anne
- Ellsworth Janet
- Enciso Pelaez Sandra
- Eraso Ruth
- Espada Graciela
- Estrella Amparo Ibanez
- Farfan Maximiliano
- Feldman Brian M
- Fernandes Taciana
- Fiorot Fernanda Jusan
- Flores Francisco
- Foell Dirk
- Fonseca Adriana
- Fotis Lampros
- Ganser Gerd
- Garay Stella
- Gedalia Abraham
- Goilav Beatrice
- Goilav Beatrice
- Grom Alexei
- Guariento Andressa
- Guedes Margarida
- Gusman Catherine
- Harjacek Miroslav
- Hashad Soad
- Henrickson Michael
- Hermosilla Cecilia Coto
- Hernandez-Huirache Hayde
- Hinze Claas
- Holland Michael J
- Hom Christine
- Houghton Kristin
- Huber Adam
- Hufnagel Markus
- Huggins Jennifer
- Jaime Martha Jarquin
- Jelusic Marija
- Jerath Rita
- Jones Jordan
- Joos Rik
- Jung Lawrence
- Jurado Rosario
- Kamphuis Sylvia
- Keltsev Vladimir
- Khubchandani Raju
- Kimseng Karen Joy
- Kingsbury Daniel
- Klein-Gitelman Marisa S
- Ladino Mabel
- Lai Jamie
- Lee Senq J
- Len Claudio
- Levy Deborah M
- Lim Sern Chin
- Lopez-Benitez Jorge
- Lopez-Robledillo Juan Carlos
- Lovell Daniel
- Lutz Thomas
- Machado Sandra
- Maggio Maria Cristina
- Maldonado Velazquez Rocio
- Maldonado Irama
- Marcantoni Maria
- Marcela Alvarez
- Marques Luciana
- Mckay Damien
- Meiorin Silvia
- Miraval Tatiana
- Modesto Consuelo
- Mosquera Angela
- Moulin Rodrigo
- Nanda Kabita
- Nielsen Susan
- Nocton James
- Norambuena Ximena
- O'Neil Kathleen
- Oliveira Sheila Knupp
- Olson Judyann
- Onel Karen
- Opoka-Winiarska Violetta
- Orban Ilonka
- Org Paediat Rheumatology Int Trial
- Orozco Javier
- Pain Clare
- Pedroso Soraya
- Pileggi Gecilmara
- Pilkington Clarissa
- Piper Susan
- Punaro Lynn
- Quintero-Del Rio Ana
- Rama Maria Elena
- Ramirez Miramontes Julia Veronica
- Ravelli Angelo
- Reiff Andreas
- Rodriguez-Lozano Ana Luisa
- Rojas Pacheco Omar Ernesto
- Romanelli Paulo Roberto S
- Rouster-Stevens Kelly
- Ruiz Lopez Ivon Karina
- Rumba-Rozenfelde Ingrid
- Ruperto Nicolino
- Russo Ricardo
- Ruth Natasha
- Rutkowska-Sak Lidia
- Saad-Magalhaes Claudia
- Sakamoto Ana
- San Ildefonso Marta Medrano
- Santos Maria Carolina
- Sawhney Sujata
- Schikler Ken
- Schmidt Kara Murphy
- Schonenberg-Meinema Dieneke
- Schulert Grant
- Shaham Bracha
- Silva Clovis A
- Silva Marco Felipe
- Singer Nora
- Smith Judith
- Smolewska Elzbieta
- Sotoca-Fernandez Jorge
- Sparchez Mihaela
- Spelling Paulo
- Suarez Larios Luz Maria
- Sundel Robert
- Susic Gordana
- Suwairi Wafaa
- Syverson Grant
- Sztajnbok Flavio
- Terreri Maria
- Tineo Carmen
- Trachana Maria
- Trauzeddel Ralf
- Tsitsami Elena
- Tucker Lori
- Vega Cynthia
- Vega Gabriel
- Vega-Fernandez Patricia
- Vehe Richard
- Velasquez Monica
- Vijatov-Djuric Gordana
- Vilaiyuk Soamarat
- Wagner-Weiner Linda
- Walsh Carolina Torre
- Wenderfer Scott E
- Yan Jaqueline
- Ying Jun
- Zamparo Celso
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
10.1002/acr.23834ARTHRITIS CARE & RESEARCH715579-59
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
- Author
- Abel K
- Adamali H.
- Adeloye D
- Adeyemi Oluwaseun
- Adrego Rita
- Aguilar Jimenez Laura A.
- Ahmad Haider N
- Ahmad Shanaz
- Ahmed R
- Ahwireng Nyarko
- Ainsworth Mark
- Al-Sheklly B.
- Alamoudi Asma
- Alfaro-Almagro Fidel
- Ali Mariam
- Aljaroof M
- Allan L
- Allen R J
- Allerton Lisa
- Allsop Lynne
- Allt Ann Marie
- Almeida Paula
- Altmann Danny
- Alvarez Corral Maria
- Amoils S.
- Anderson David
- Antoniades C
- Arbane Gill
- Arias Ava Maria
- Armour C.
- Armstrong Lisa
- Armstrong Natalie
- Arnold David
- Arnold H
- Ashish A
- Ashworth Andrew
- Ashworth M
- Aslani S
- Assefa-Kebede Hosanna
- Atkin C
- Atkin Paul
- Aul Raminder
- Aung H
- Austin Liam
- Avram Cristina
- Ayoub A.
- Babores M.
- Baggott R
- Bagshaw J
- Baguley D
- Bailey L
- Baillie J.K.
- Bain S
- Bakali M
- Bakau M
- Baldry E
- Baldwin D
- Baldwin M
- Ballard C
- Bandula Steven
- Banerjee A
- Bang Dongchun
- Barker R E
- Barman L
- Barratt Shaney
- Barrett Fiona
- Basire Donna
- Basu N.
- Bates A
- Bates M
- Batterham R
- Baxendale H
- Bayes Hannah
- Beadsworth M.
- Beckett P
- Beggs Mark
- Begum M
- Beirne Paul
- Bell Murdina
- Bell R
- Bennett Kaytie
- Beranova Eva
- Bermperi Areti
- Berridge Anthony
- Berry C.
- Betts Sarah
- Bevan Emily
- Bhui K
- Bingham Michelle
- Birchall K
- Bishop L.
- Bisnauthsing Karen
- Blaikely J.
- Bloss Angela
- Bolger A.
- Bolton Charlotte E.
- Bonnington J.
- Botkai A
- Bourne Charlotte
- Bourne Michelle
- Bramham K.
- Brear Lucy
- Breen G
- Breeze Jonathon
- Briggs A.
- Bright E
- Brightling Christopher E
- Brill Simon
- Brindle K
- Broad Lauren
- Broadley A
- Brookes C
- Broome M
- Brown Ammani
- Brown Angela
- Brown J.
- Brown Jeremy S
- Brown Jo
- Brown M.
- Brown M.
- Brown V.
- Brugha Terry
- Brunskill Nigel
- Buch M.
- Buckley Phil
- Bularga A.
- Bullmore E
- Bunker Jenny
- Burden L.
- Burdett Tracy
- Burn D.
- Burns A.
- Burns G.
- Busby J.
- Butcher Robyn
- Butt Al-Tahoor
- Byrne S.
- Cairns P
- Calder P C
- Calvelo Ellen
- Carborn H
- Card Bethany
- Carr Caitlin
- Carr Liesel
- Carson G
- Carter Penny
- Casey A
- Cassar Mark P.
- Cavanagh J
- Chablani Manish
- Chalder Trudie
- Chalmers James D.
- Chambers R C
- Chan Flora
- Channon K M
- Chapman Kerry
- Charalambou A
- Chaudhuri N
- Checkley A
- Chen Jin
- Cheng Yutung
- Chetham Luke
- Childs C
- Chilvers Edwin R
- Chinoy H
- Chiribiri Amedeo
- Chong-James K.
- Choudhury Gourab
- Choudhury N.
- Chowienczyk P
- Christie C
- Chrystal Melanie
- Clark Cameron
- Clark D
- Clarke Jude
- Clohisey S.
- Coakley G.
- Coburn Zach
- Coetzee S.
- Cole Joby
- Coleman C
- Conneh Florence
- Connell David
- Connolly B.
- Connor Lynda
- Cook Amanda
- Cooper B
- Cooper J
- Cooper Shirley
- Copeland D.
- Cosier Tracey
- Coulding Martina
- Coupland C.
- Cox Eleanor
- Craig T.
- Crisp P
- Cristiano Daniele
- Crooks M.G.
- Cross Andy
- Cruz Isabel
- Cullinan P.
- Cuthbertson Dan J
- Daines L
- Dalton Matthhew
- Daly Patrick
- Daniels Alison
- Dark P
- Dasgin J
- David A
- David C.
- Davies Ellie
- Davies Ffyon
- Davies Gareth
- Davies Gwyneth A
- Davies Kim
- Davies Melanie J
- Dawson Joy
- Daynes E
- De Soyza Anthony
- Deakin B
- Deans Andrew
- Deas C.
- Deery Joanne
- Defres S.
- Dell Amanda
- Dempsey K.
- Denneny E
- Dennis J
- Dewar A.
- Dharmagunawardena R
- Diar Bakerly Nawar
- Dickens C
- Dipper A.
- Diver Sarah
- Diwanji Shalin N
- Dixon Myles
- Djukanovic R
- Dobson H.
- Dobson S.L.
- Docherty Annemarie B.
- Donaldson A.
- Dong T.
- Dormand N.
- Dougherty Andrew
- Dowling R
- Drain S.
- Draxlbauer K
- Drury Katie
- Dulawan Pearl
- Dunleavy A
- Dunn Sarah
- Dupont Catherine
- Earley Joanne
- Easom Nicholas
- Echevarria Carlos
- Edwards Sarah
- Edwardson C
- El-Taweel Hosni
- Elliott Anne
- Elliott K
- Ellis Y.
- Elmer Anne
- Elneima Omer
- Evans D
- Evans H
- Evans J
- Evans R
- Evans Rachael A
- Evans Ranuromanana I.
- Evans Teriann
- Evenden Cerys
- Evison Lynsey
- Fabbri L
- Fairbairn Sara
- Fairman Alexandra
- Fallon K.
- Faluyi David
- Favager Clair
- Fayzan Tamanah
- Featherstone James
- Felton T.
- Ferreira Vanessa M.
- Finch J
- Finney Selina
- Finnigan J
- Finnigan Lucy
- Fisher Helen
- Fletcher S
- Flockton Rachel
- Flynn Margaret
- Foot H
- Foote David
- Ford Amber
- Forton D
- Fraile Eva
- Francis C.
- Francis R
- Francis Susan
- Frankel A.
- Fraser Emily
- Free Rob
- French N.
- Fu X
- Fuld Jonathan
- Furniss J.
- Garner Lucie
- Gautam N
- Geddes John R.
- George J.
- George P.
- Gibbons M
- Gill Mandy
- Gill Rhyan
- Gilmour L.
- Gleeson Fergus
- Glossop Jodie
- Glover Sarah
- Goodman N
- Goodwin Camelia
- Gooptu Bibek
- Gordon Hussain
- Gorsuch T.
- Greatorex M
- Greenhaff P.L.
- Greenhalf William
- Greenhalgh Alan
- Greening Neil J
- Greenwood John P
- Gregory Heidi
- Gregory Rebecca
- Grieve D.
- Griffin Denise
- Griffiths L
- Guerdette Anne-Marie
- Guillen Guio Beatriz
- Gummadi Mahitha
- Gupta Ayushman
- Gurram Sambasivarao
- Guthrie E
- Guy Z
- Hadley K
- Haggar Ahmed
- Hainey Kera
- Hairsine Brigid
- Haldar Pranab
- Hall I
- Hall Lucy
- Halling-Brown Mark
- Hamil R.
- Hancock Alyson
- Hancock Kia
- Hanley N.A.
- Haq Sulaimaan
- Hardwick H.E.
- Hardy E
- Hardy Tim
- Hargadon Beverley
- Harrington Kate
- Harris Edward
- Harris Victoria C
- Harrison Ewen M.
- Harrison P.
- Hart Nicholas
- Harvey Alice
- Harvey M
- Harvie M
- Haslam L
- Hastie Claire
- Havinden-Williams May
- Hawkes Jenny
- Hawkings Nancy
- Haworth Jill
- Hayday A.
- Haynes Matthew
- Hazeldine J
- Hazelton Tracy
- Heaney Liam G.
- Heeley Cheryl
- Heeney J L
- Heightman M
- Heller S.
- Henderson M
- Henson Helen
- Hesselden L
- Hewitt Melanie
- Highett Victoria
- Hillman T
- Hiwot T
- Ho Ling-Pei
- Hoare Amy
- Hoare Michaela
- Hockridge J
- Hogarth Philip
- Holbourn Ailsa
- Holden S
- Holdsworth L.
- Holgate D
- Holland Maureen
- Holloway Leah
- Holmes Katie
- Holmes Megan
- Holroyd-Hind B
- Holt L
- Hormis Anil
- Horsley Alexander
- Hosseini A.
- Hotopf M
- Houchen-Wolloff Linzy
- Howard K
- Howard Luke S.
- Howell Alice
- Hufton E
- Hughes A D
- Hughes Joan
- Hughes Paul J C
- Hughes Rachel Ann
- Humphries Amy
- Huneke N
- Hurditch E
- Hurst John R
- Husain M
- Hussell T.
- Hutchinson John
- Ibrahim W
- Ilyas F
- Ingham Julie
- Ingram L
- Ionita D
- Isaacs K
- Ismail K.
- Jackson T
- Jacob Joseph
- James W.Y.
- Jang W.
- Jarman Claire
- Jarrold I.
- Jarvis Hannah
- Jastrub Roman
- Jayaraman Bhagy
- Jenkins R Gisli
- Jezzard Peter
- Jiwa Kasim
- Johnson C
- Johnson S
- Johnston D.
- Jolley Caroline J.
- Jones Don
- Jones G.
- Jones H.
- Jones Heather
- Jones I.
- Jones L.
- Jones Mark G
- Jones S.
- Jose Sherly
- Kabir T.
- Kaltsakas G.
- Kamwa V
- Kanellakis N.
- Kaprowska Sabina
- Kausar Zunaira
- Keenan Natalie
- Kelly Matthew
- Kelly S.
- Kemp Graham J
- Kerr Steven
- Kerslake Helen
- Key Angela L.
- Khan F
- Khunti Kamlesh
- Kilroy Susan
- King Bernie
- King Clara
- Kingham L
- Kirk Jill
- Kitterick P
- Klenerman P
- Knibbs Lucy
- Knight Sean
- Knighton Abigail
- Kon Onn M
- Kon S
- Kon Samantha S
- Korszun A.
- Koychev Ivan
- Kurasz Claire
- Kurupati Prathiba
- Laing C
- Lamlum Hanan
- Landers G
- Langenberg C
- Lasserson D
- Lavelle-Langham L.
- Lawrie Allan
- Lawson C
- Lawson Cathy
- Layton Alison
- Lea A
- Leavy Olivia C
- Lee D
- Lee Elvina
- Lee Ju Hee
- Leitch Karen
- Lenagh Rebecca
- Lewis D
- Lewis J.
- Lewis Keir E
- Lewis Victoria
- Lewis-Burke N.
- Li X
- Light Tessa
- Lightstone L.
- Lilaonitkul W
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- Yasmin Najira
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- Zawia Amira
- Zeidan Lisa
- Zhao Bang
- Zheng Bang
- Zongo O.
- Publication venue
- Elsevier
- Publication date
- 22/09/2023
- Field of study
Introduction:
The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures.
Methods:
In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025.
Findings:
Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.
Interpretation:
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway
- Author
- Aanensen David M.
- Abraham Priyanka
- Abudahab Khalil
- Adams Alexander
- Adams Helen
- Adele Sandra
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad S. Y.
- Aigrain Louise
- Alcolea-Medina Adela
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Angyal Adrienn
- Annett Tara
- Ansari M. Azim
- Aplin Stephen
- Ariani Cristina V.
- Asad Hibo
- Asamaphan Patawee
- Ash Amy
- Ashfield Paula
- Ashford Fiona
- Ashraf Shirin
- Atkinson Laura
- Attwood Stephen W.
- Auckland Cressida
- Austin James
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barnes Eleanor
- Barrett Jeffrey C.
- Barrow Magdalena
- Barton Edward
- Bashton Matthew
- Bassett Andrew R.
- Batra Rahul
- Baxter Chris
- Bayzid Nadua
- Beaver Charlotte
- Beckett Angela H.
- Beckwith Shaun M.
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L.
- Berry Louise
- Bertolusso Beatrice
- Best Angus
- Betteridge Emma
- Bibby David
- Bicknell Kelly
- Binns Debbie
- Birchley Alec
- Bird Paul W.
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Bouzidi Kate El
- Boyd Olivia
- Bradley Declan T.
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgett Stephen
- Bronner Iraad F.
- Brooks Ellena
- Broos Alice
- Brown Anthony
- Brown Julianne R.
- Bucca Giselda
- Buchan Sarah L.
- Buck David
- Bull Matthew
- Burns Phillipa J.
- Burton-Fanning Shirelle
- Byaruhanga Timothy
- Byott Matthew
- Campbell Sharon
- Cantoni Diego
- Carabelli Alessandro M.
- Cargill James S.
- Carlile Matthew
- Carvalho Sílvia F.
- Casey Anna
- Castigador Anibolina
- Catalan Jana
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- Cowton Vanessa
- Cox Alison
- Cox MacGregor
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- Crawford Liam
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- Crudgington Dorian
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- Debebe Johnny
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- Dias Joana
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- Pugh Georgia
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- Sambles Christine M.
- Sanderson Roy
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- Sang Fei
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- Stanley William
- Stanton Thomas D.
- Starinskij Igor
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Studholme David J.
- Sudhanva Malur
- Swindells Emma
- Szemiel Agnieszka
- Taha Yusri
- Tan Ngee Keong
- Tang Julian W.
- Tang Miao
- Taylor Ben E. W.
- Taylor Joshua F.
- Taylor Sarah
- Temperton Ben
- Templeton Kate
- Templeton Kate E.
- Thomas Claire
- Thomson Emma C.
- Thomson Emma C.
- Thomson Laura
- Thornton Alicia
- Thurston Scott A. J.
- Todd John A.
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- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Tovar-Corona Jaime M.
- Trebes Amy
- Trotter Alexander J.
- Tsatsani Ioulia
- Turnbull Robyn
- Turtle Lance
- Twohig Katherine A.
- Umpleby Helen
- Underwood Anthony P.
- Vamos Edith E.
- Vasylyeva Tetyana I.
- Vattipally Sreenu
- Vernet Gabrielle
- Vink Elen
- Vipond Barry B.
- Volz Erik M.
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- Warne Ben
- Warwick-Dugdale Joanna
- Wastnedge Elizabeth
- Watkins Joanne
- Watson Louisa K.
- Waugh Sheila
- Webster Hermione J.
- Weldon Danni
- Westwick Elaine
- Whalley Thomas
- Wheeler Helen
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Wilkie Craig
- Willett Brian J.
- Willford Nicholas J.
- Williams Catryn
- Williams Charlotte A.
- Williams Cheryl
- Williams Chris
- Williams Lesley-Anne
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Wilson-Davies Eleri
- Witele Eric
- Withell Karen T.
- Witney Adam A.
- Wolverson Paige
- Wong Nick
- Workman Trudy
- Wright Derek W.
- Wright Victoria
- Wyatt Tim
- Wyllie Sarah
- Xu-McCrae Li
- Yavus Mehmet
- Yaze Geraldine
- Yeats Corin A.
- Yebra Gonzalo
- Yebra Gonzalo
- Yew Wen C.
- Young Gregory R.
- Young Jamie
- Zarebski Alex E.
- Zhang Peijun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/08/2022
- Field of study
Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC to be described, harbours multiple amino acid mutations in spike, half of which lie within the receptor-binding domain. Here we demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 and mRNA-1273. These data were mirrored by a substantial reduction in real-world vaccine effectiveness that was partially restored by booster vaccination. The Omicron variants BA.1 and BA.2 did not induce cell syncytia in vitro and favoured a TMPRSS2-independent endosomal entry pathway, these phenotypes mapping to distinct regions of the spike protein. Impaired cell fusion was determined by the receptor-binding domain, while endosomal entry mapped to the S2 domain. Such marked changes in antigenicity and replicative biology may underlie the rapid global spread and altered pathogenicity of the Omicron variant
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
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- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
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- Beddows Seonaid
- Bedford Caroline
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- Beer Sally
- Begin Phillipe
- Begum Salma
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- Bensen Nicole
- Bentley Andrew
- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
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- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bharaj Kiranjit
- Bhattarai Bina
- Bhattarai Binita
- Bhonagiri Deepak
- Biddie Simon
- Bigas Judit
- Bihari Shailesh
- Bin Hasan Mohd Shahnaz
- Bindels Manon
- Binnie Alexandra
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- Boivin Anne-Hélène
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- Bongaerts Katherine
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- Borislavova Borislava
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- Bradley Paul
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- Day Christopher
- Da Rocha Joana
- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
- de Jonge Evert
- De Keulenaer Bart
- de la Torre Cisneros Julian
- de Man Angelique
- De Neef Mark
- De Smeytere Anouska
- Deacon Bethan
- Dean Steven
- Dean Tessa
- Dearden Joy
- Dechert William
- Declercq Pierre-Louis
- Degracia Anna
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Dell Abbie
- del Prado Michael
- Demetriou Carrie
- Dempster Debra
- Denham Lynn
- Denmade Craig
- Dent Martin
- Depante Maria
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
- Dheke Krishan
- Di Lucca Giuseppe
- Dias Priya
- Dice Julie
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- Diridis Kristina
- Distler Michael
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- Doherty Ronan
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- Marsh Emma
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- Marten Nicole
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- Mc-Kenzie Josette
- McAdams David
- McArthur Colin J.
- McAuley Daniel F.
- McAuley Julie
- McCallion Edmund
- McCarthy Aine
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- McCracken Phoebe
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- McGoldrick Clare
- McGuigan Peter
- McGuinness Shay P.
- McIntyre Joanne
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- McVerry Bryan J.
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- Mouncey Paul R.
- Mowery Brent
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- O?Brien Neale
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- Owen David R. J.
- Oza Deepali
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- Panjwani Ashok
- Panwar Rakshit
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- Paramasivam Elankumaran
- Parekh Dhruv
- Parikh Harshel G.
- Parke Rachael L.
- Parker Jane C.
- Parker Lorraine
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- Pegler Suzannah
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- Plummer Bethany
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- Pogson David
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- Polgarova Petra
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- Pollock Katrina M.
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- Poojara Latesh
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- Rad Laura
- Rademaker Emma
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- Raithatha Ajay
- Raj Ashok
- Ralston Maximillian
- Ramakrishnan N
- Ramali Mohamed
- Ramamurthi Balaji
- Ramanan Mahesh
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- Ranganathan Lakshmi
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- Rouge Patrick
- Roumen Rudy
- Rounds Charles
- Rovere-Querini Patrizia
- Rowan Kathryn M.
- Rowe-Leete Louise
- Rowland Matthew
- Roy Alistair
- Roynon-Reed Anna
- Rueß-Paterno Giusi
- Ruiz Winningtom
- Runge Isabelle
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- Salvati Stefano
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- Sandhu Gyan
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- Santamaria John
- Santos Filipa
- Santos Marlene S.
- Sapsford David
- Sara Treena
- Saran Anita
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- Sathianathan Kushaharan
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- Saull Michelle
- Saunders Christina T.
- Saunderson Paula
- Sauras-Colón Esther
- Saxena Manoj
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- Senya Ho
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- Serri Karim
- Sevilla Chanthou
- Seymour Christopher W.
- Shah Faraaz
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- Sprinckmoller Stefan
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- Stambaugh Martha
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- Stone Sarah
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- Stronach Lucy
- Suber Tomeka
- Sukuraman Anila
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- Sundaram Radha
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- Surti Zuhra
- Sutherland Helen
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- Sutton Joanne
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- Sven?ek Franc
- Svit?kar Nikolai
- Swabe Jacqueline
- Sweet Katie
- Sy Eric
- Szakmany Tamas
- Szawarski Piotr
- Tai Charlotte
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- Thurairatnam Saranya
- Tierney Carey
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- Toffalo Sue
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- Tomasi Enrico
- Tomlinson Helen
- Tong Steve
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- Totzke Juliane
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- Tsinaslanidis Georgios
- Tuckwell Caroline
- Tully Redmond
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- Tung Raymond
- Tupper-Carey Daryl
- Turgeon Alexis F.
- Turki Salah
- Turner Anne M.
- Turner Elizabeth
- Turner Keri
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- Udayanga Ishara
- Uddin Ruzena
- Udy Andrew
- Ullmann Hannah
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- Ustianowski Andrew
- Uyeki Tim
- Vaara Suvi
- Vaduganathan Muthiah
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- Vale Cassandra
- Valentine Eliza
- Vamplew Luke
- van Amerongen Roosmarijn
- van Bentum-Puijk Wilma
- van Bree Sjoerd
- van de Veerdonk Frank L.
- van den Berg Lettie
- van den Oever Huub
- van der Eng Hetty
- Van Der Heyden Kymbalee
- van der Kraan-Donker Annemarie
- van Gulik Laura
- van Haren Frank
- Van Hecke Jolien
- van Kimmenade Roland
- van Nieuwkoop Kees
- van Zanten Arthur
- van Zuylen Tamara
- Van?t Hoff William
- Vandewoestyne Sophie
- Vanjak Christian
- Vanmali Piyush
- van Opdorp Marjolein
- van Vonderen Marit
- Vargas Jr. Jesus
- Varghese Siby
- Vautier Sarah
- Vazquez-Grande Gloria
- Veenith Tonny
- Veillard Marion
- Venkatesh Bala
- Verlander Mark
- Vermassen Joris
- Vermeiren Daisy
- Vermont - van der Staaij Janine
- Verrier Nathalie
- Vertue Mark
- Verula Jerik
- Victor Saji
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- Vieillard-Baron Antoine
- Vignesh C
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- Vilá Clara
- Vincent Rachel
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- Visentin Elisa
- Visser Yorik
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- Vivier Dominique
- Vodovar Dominique
- Voicu Sebastian
- Voigt Ingo
- Voiriot Guillaume
- Volkov Lev
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- Vuylsteke Alain
- Wada Asako
- Waddington Natalia
- Wahl Nadine
- Waite Alicia
- Walden Andrew
- Walker Gena
- Walker Rachel
- Walker Susan
- Walsh Joanne
- Walsh Tim
- Walsham James
- Walton Catherine
- Wang Shu
- Ward Geraldine
- Ward Kathryn
- Ward Luke
- Warnapura Loku
- Warnock Majella
- Watchorn Olivia
- Waters Abby
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Watts Angela
- Waugh Victoria
- Webb Steve A.
- Weber Lisa
- Webster Denise
- Weerasinghe Thanuja
- Weismann Dirk
- Weiss Daniel
- Weissman Alexandra
- Wells Alan
- Wells Colin
- Wells Karen
- Welters Ingeborg
- West Lauren
- Westlake Samantha
- Wetherill Bill
- Wetzold Richard
- Whileman Amanda
- Whitbread Jennifer
- White Alison
- White Hayden
- White Ian
- White Katie
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- Whitehouse Tony
- Wibrow Bradley
- Wigbers Jeanette
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- Wilcox Elizabeth
- Wilcox Louise
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- Wilding Laura
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- Williams Anna
- Williams Erin
- Williams Gemma
- Williams Hannah
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- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James D
- Willis Joanna
- Willson Jayne
- Wilson Anna
- Wilson Craig
- Wilson Jean
- Wilson Maggie
- Winters James
- Winters Lauren
- Wise Matt
- Wisniewski Mary
- Wittekamp Bastiaan
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
- Wong Jenny
- Wong Onyee
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Woodward Robert
- Woolett Melissa
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
- Author
- Aanniz Tarek
- Abar Aden Elmi
- Abbad Anass
- Abdelfattah May
- Abdelhamid W.
- Abdella Saro
- Abdellah Faouzi
- Abdelmjid El Oualid
- Abdelmoula Fatma
- Abdelmoulah F.
- Abderrahmane Maaroufi
- Abderrazak Rfaki
- Abdillahi Idil Salah
- Abdissa Alemseged
- Abdo I.
- Abdoelraheem Mohamed Hassan
- Abe Haruka
- Abebe Markos
- Abechi Priscilla
- Abera Adugna
- Abi Rachid
- Abias Abe G.
- Abichu Getachew
- Abid N.
- Abid Nabil
- Abid Salma
- Abilio Nuro
- Abimbola Sharon
- Abo Shama Noura M
- Abosede O.
- Aboubaker Mohamed Houmed
- Abouelhoda Mohamed
- Abouelnaga S.
- Abualas Elamin
- Abubeker Ramalia Chabi
- Abuelenein Ehab Abdelkader
- Abuzaid Nadir
- Abworo Edward O.
- Ada Diosdado Odjama Nseng
- Addidle Michael
- Adegbola Richard
- Adegnika Akim A.
- Adegnika Ayola Akim
- Adel Abd Monaem
- Adeniji Johnson A.
- Adepetun Tomiwa
- Adesegun A.
- Adesuyi Omoare
- Adetifa Ifedayo M. O.
- Adewumi Olubusuyi M.
- Adewumi Oluwatimilehin
- Adewumi Praise
- Adeyemi Kayode T.
- Adhikari Bishwo N.
- Adil El Hamouchi
- Adjiratou Aissatou B. A.
- Adnew Bethlehem
- Adu Bright
- Adu Eric
- Adusei-Poku Mildred
- Agbenyo Seyram Bless
- Agbodzi B.
- Ageez A.M.
- Agoti Charles N.
- Aguenaou Hassan
- Agwa Sara Hassan
- Agweyu Ambrose
- Ahmed El Bara
- Ahmed Elhadi A.
- Ahmed Hatem
- Ahmed M.
- Ahmed O. S.
- Ahmed Rahma
- Ahmed Shymaa S.
- Ahmed Side Mohamed
- Ahmed Yahaya Ali
- Ahouidi Ambroise
- Ahuka-Mundeke Steve
- Ahumibe Anthony
- Ahyong Vida
- Aissam El Aliani
- Ajayi Nnennaya A.
- Ajibaye Solomon
- Ajili F.
- Ajogbasile F.V.
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- Akhoud Youssef
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- Alaoui-Amine Sanaa
- Alarif Ahlam
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- Albert Mélanie
- AlEmam Adba Alfatih
- Alemayehu Dawit Hailu
- Alemu Fekadu
- Algheriani Raiva
- Ali Abraham
- Ali M.A.
- Ali Mohamed Ahmed
- Ali Mushal
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- Allam Loubna
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- Borrmann Steffen
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- Diarra B.
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- Djimde Abdoulaye
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- Helmy Sherine
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- Hicham Elannaz
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- Hope Virginia
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- Houda Harmak
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- Howard Julia
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- Jo Wendy Karen
- JOEL Ireoluwa Yinka
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- Johnson Bankole
- Joloba Moses
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- Kagoné Thérèse
- Kakai Clement G.
- Kalantar K.
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- Kamara Santigie
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- Kamoun S.
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- Kapata P.C.
- Kapaya F.
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- Karim Wasim Abdul
- Karray Hakim H.
- Karray Hela
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- Katyshev A.D.
- Kavunga-Membo Hugo
- Kay Gemma L.
- Kayali Ghazi
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- Kazeem Akano
- Kazorina E.V.
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- Kemi Adedotun-Sulaiman
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- Kezakarayagwa Eric
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- Khalid Ennibi
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- Khan Adam K.
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- Kiiza Ronald
- Kim L.
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- Kimotho J.
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- Kotey Erasmus
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- Krasnov Y.M.
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- Kritsky A.A.
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- Kumordjie Selassie
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- Lessler Justin
- Leta D.
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- Maruapula Dorcas
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- Maufrais Corinne
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- Mayaphi Sim
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- Maïté Soundélé
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- Ndiour Samba
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- Raouf A.
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- Sadji
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- Shiningavamwe Andreas
- Shipingana Loide
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- Siedner Mark
- Siegfried Nandi
- Sigei Faith
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- Stefanov Emily K.
- Stoecker Kilian
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- Sujeewon C.
- SULAIMAN Mariam Kehinde
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- Tayachew Adamu
- Tayimetha Carolle Yanique
- Taylor Susan
- Tchibozo Carine
- Tchoudjin Herve Christian Paho
- Tebeje Yenew K.
- Tefelo Thela
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- Tefera Dessalegn Abeje
- Tegally Houriiyah
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- Tessema Sofonias K.
- Testimony Olumade
- Thiam Aminata Sileymane
- Thilliez Gaetan
- Thiongo K.
- Thomas Van L.
- Tia Alie
- Tinto Halidou
- Tollera Getachew
- Tombolomako T. B.
- Tomkins-Tinch C.
- Tomori Oyewale
- Tongo Marcel
- Top Ndeye Marieme
- Tordo Noël
- Toure Abdoulaye
- Touré Bamba Fatoumata
- Touzani Charifa Drissi
- Touzani Otmane
- Trabelsi Sameh
- Traoré
- Traoré Adjaratou
- Treurnicht Florette
- Triki H.
- Triki Henda
- Trotter Alexander J.
- Tsegay Yao
- Tshiabuila Derek
- Tsiry R.
- Tsofa Benjamin
- Tuki Keyru
- Tumedi Kefentse A.
- Turki M.
- Tushabe Phionah
- Tuyisenge Patrick
- Tyers Lynn
- Uche Peace O.
- Ugwu C.A.
- Ulrich M.
- Umumararungu Esperance
- Umuringa Jeanne d’Arc
- Upton Arlo
- Ushijima Yuri
- Ussher James
- Utpatel Christian
- Uwanibe Jessica N.
- Uwituze Arlene
- van der Eijk Annemiek
- van der Linden Anne
- van der Linden Antje
- van der Werf Sylvie
- Van Rooyen G.
- van Rooyen Gerhard
- van Wyk Stephanie
- van Zyl Gert U.
- Vanaerschot M.
- Vanmechelen Bert
- Vanpeene Maud
- Velavan Thirumalaisamy P.
- Venter Marietjie
- Vernet Marie-Astrid
- Viana R.
- Vickos U.
- Victoir Kathleen
- Vida Ahyong
- Vidal Nicole
- Viegas Sofia
- Vincent Grace
- Vinze Anika
- Voegtly Logan J.
- von Gottberg Anne
- Waberi Zeinab Ali
- Wadi Amira Suliaman
- Wadonda N.
- Wadula J.
- Wagner Philipp
- Wahab Kolawole Wasiu
- Waitumbi John
- Walter Mathias C.
- Wamala Joseph F.
- Wandera Dennis N.
- Wang Jing
- Wang Xiuhua
- Wani Gregory
- Wanjohi Dorcas W.
- Wanok Stephen
- Waruhiu C.N.
- Waruhiu Cecilia
- Wasfi Fares
- Watters Chaselynn M.
- Wawina-Bokalanga Tony
- Wayengera Misaki
- Wayoro Oby
- Webby R.
- Webby Richard
- Weldemariam A.G.
- Weldemariam Atsbeha G.
- Werno Anja
- Wiley Michael R.
- Wilkinson David
- Wilkinson Eduan
- Williamson Carolyn
- Wilson Shannon
- Woelfel R.
- Wohl Shirlee
- Wolh S.
- Wolter Nicole
- Wuduri Zara
- Wulf Ben
- Wurie I.
- Wurie Isatta
- Xavier Joicymara S.
- Xiang Zuzheng
- Xie Hong
- Yadouleton Anges
- Yadouleton Yahya
- Yakout Mostfa
- Yandoko Rivalyn Nakoune
- Yang Qi
- Yao Kouadio T.
- Yassine Kasmi
- Yassine Zouheir
- Yasuda Jiro
- Yatassaye Bouna
- Yeboah C.
- Yeboah Richmond
- Yeboah-Manu Dorothy
- Yemi Bright K.
- Yiaba Cyrus
- Yiaba Warren Cyrus
- Yu Popova A.
- Yusuf Nyam Itse
- Yusuf Yacob Mohamed
- Zablon J. Matoke D.
- Zablon J.O.
- Zaher Tarek Refaat Elnagdy Raafat
- Zahra El Ansari Fatima
- Zahran Manal Hamdy
- Zekri Abdel-Rahman N.
- Zhang J.
- Zhou Pei
- Zinyowera Sekesai
- Zong Minko O.
- Zongo Arsène
- Zorgani A.
- Zouaki Amal
- Zulu P.
- Zumla Ali
- Zumla Alimuddin
- Zuze Boitumelo
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 07/10/2022
- Field of study
INTRODUCTION
Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic.
RATIONALE
We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs).
RESULTS
Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants.
CONCLUSION
Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century