Disruption of Coronin 1 Signaling in T Cells Promotes Allograft Tolerance while Maintaining Anti-Pathogen Immunity

The ability of the immune system to discriminate self from non-self is essential for eradicating microbial pathogens but is also responsible for allograft rejection. Whether it is possible to selectively suppress alloresponses while maintaining anti-pathogen immunity remains unknown. We found that mice deficient in coronin 1, a regulator of naive T cell homeostasis, fully retained allografts while maintaining T cell-specific responses against microbial pathogens. Mechanistically, coronin 1-deficiency increased cyclic adenosine monophosphate (cAMP) concentrations to suppress allo-specific T cell responses. Costimulation induced on microbe-infected antigen presenting cells was able to overcome cAMP-mediated immunosuppression to maintain anti-pathogen immunity. In vivo pharmacological modulation of this pathway or a prior transfer of coronin 1-deficient T cells actively suppressed allograft rejection. These results define a coronin 1-dependent regulatory axis in T cells important for allograft rejection and suggest that modulation of this pathway may be a promising approach to achieve long-term acceptance of mismatched allografts

Mikroskopische Transporterscheinungen in atmosphaerischen Aerosolen

Available from TIB Hannover: DW 7414 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Verfahren zur Messung der Luftstaubkonzentration

Ein in einfacher Weise betreibbares und kostenguenstig arbeitendes Verfahren zur Messung der Luftstaubkonzentration wird dadurch geschaffen, dass die Abscheidung der luftgetragenen Partikel aus einem definierten Messvolumen durch eine Koronaentladung herbeigefuehrt wird. Die Koronaentladung wird gepulst betrieben. Zur Fuellung des Messvolumens wird die natuerliche Konvektionsstroemung verwendet. Nach der Koronaentladung in der Zeit t<e haben die aufgeladenen Partikel anschliessend die Zeit t<a fuer die Ablagerung zur Verfuegung. Die Fuellung des Messvolumens erfolgt waehrend der Zeit t<k, worauf der Zyklus mit der naechsten Koronaentladung erneut beginnt. Beim konvektiven Fuellvorgang des Messvolumens treten keine signifikanten Verluste groesserer Partikel auf

Design and performance of an aerosol reactor for photochemical studies

A photoreactor was designed to optimize aerosol life times for photochemical studies. Aerosol decay rate was in the range 0.04-0.4 per hour depending on particle size. Good agreement with deposition theory was obtained. (ITA

Kondensationskernzaehler

Condensation nucleus counter, comprising a humidification zone through which sample air is passed, and an approximately vertical condensation zone, and an optical detection system comprising a light source and a detector, whereby the humidification zone (1) consists of a channel (2) made of porous material (3) and a cavity (4) surrounding said channel (2), the cavity serving to receive the operating liquid, the condensation zone (5) consists of a channel (6) which is also surrounded by a cavity (7) serving to receive the cooling medium; the condensation zone (5) is connected to the humidifation zone (1) by means of a connecting piece (8)

Aerosol mass determination with nuclear track filters from quartz crystals

Irradiating quartz crystals of approx. 100 mym thickness with heavy ions (eg. 238U, 17 MeV per nucleon, 10 E5 ions cm E-2) creates heavy damage of the crystal structure along the path. Etching these quartzes with KOH, for example, produces pores with adjustable diameter. The possibility of using these quartzes as filtering mass monitoring devices was investigated. As a result a reduced Q-factor compared to untreated quartzes was obtained but the quartzes still can be employed as oscillators. Their moisture sensitivity and temperature coefficients are similar to those of normal quartzes. Their typical mass response is approx. 1 Hz ng E-1 cm E-2. The pores have a funnel shape so that cascading to obtain mass size distributions is difficult. (ITA