24 research outputs found
MOESM3 of Baseline immune profile by CyTOF can predict response to an investigational adjuvanted vaccine in elderly adults
Additional file 3. Percentage of RSV specific CD3+CD4+ and CD3+CD8+ responses
MOESM1 of Baseline immune profile by CyTOF can predict response to an investigational adjuvanted vaccine in elderly adults
Additional file 1. Mock subtracted IFNÎł responses at Day 1, at Day 8 undepleted, CD4 depleted and CD8 depleted
MOESM2 of Baseline immune profile by CyTOF can predict response to an investigational adjuvanted vaccine in elderly adults
Additional file 2. CyTOF workflow
MOESM4 of Baseline immune profile by CyTOF can predict response to an investigational adjuvanted vaccine in elderly adults
Additional file 4. Workflow to perform viSNE analysis on antigen-specific cells
Relative amounts of selected immune cell populations in cord blood samples collected at birth (n = 63<sup>*</sup>).
<p>Relative amounts of selected immune cell populations in cord blood samples collected at birth (n = 63<sup><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0179606#t003fn001" target="_blank">*</a></sup>).</p
Cord blood T cell subpopulations and associations with maternal cadmium and arsenic exposures
<div><p>Background</p><p>Arsenic and cadmium are environmental pollutants, and although the evidence for adverse immune effects after prenatal arsenic and cadmium exposures is increasing, little is known about the underlying immunological mechanisms.</p><p>Methods</p><p>We investigated the relationship between prenatal arsenic and cadmium exposures and a variety of T cell subpopulations measured in cord blood for 63 participants in the New Hampshire Birth Cohort Study. Post-partum toenail concentrations of arsenic and cadmium were used as an estimate of maternal exposure during pregnancy. The characteristics of cord blood proportions of T lymphocytes and subpopulations (expression of markers for Th1, Th2, Th17, Th1Th17, induced and natural regulatory T cells and NKTs) are presented.</p><p>Results</p><p>In regression analyses, maternal arsenic exposure levels were inversely associated with cord blood T helper memory cells (-21%, 95% CI: -36%, -3%) and the association was found to be stronger in females. They were also inversely associated with activated T helper memory cells, particularly in males (-26%, 95% CI: -43%, -3%). Similarly, inverse associations were observed between cadmium exposure levels and activated T helper memory cells (-16%, 95% CI: -30%, -1%) and also for T helper memory cells in females (-20%, 95% CI: -35%, -3%).</p><p>Conclusion</p><p>The results suggest that prenatal exposures to relatively low levels of arsenic and cadmium may contribute to altered distribution of T cell populations at birth. These changes in theory, could have contributed to the previously reported immunosuppressive effects observed later in infancy/childhood.</p></div
Associations<sup>1</sup> between maternal cadmium concentrations in postpartum toenail and immune cell subpopulations (n = 57<sup>*</sup>).
<p>Statistically significant associations are denoted in bold font. The beta values are the percent of changes in the relative immune cell numbers per doubling of cadmium exposure.</p
Correlation matrix for the different T cell subpopulations in cord blood, spearman correlation coefficients and p-values are presented, correlations with p<0.05 denoted in bold.
<p>Correlation matrix for the different T cell subpopulations in cord blood, spearman correlation coefficients and p-values are presented, correlations with p<0.05 denoted in bold.</p
Selected characteristics of the New Hampshire Birth Cohort Study participants included in the present study (n = 63<sup>*</sup>).
<p>Selected characteristics of the New Hampshire Birth Cohort Study participants included in the present study (n = 63<sup><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0179606#t001fn002" target="_blank">*</a></sup>).</p
Associations<sup>1</sup> between maternal arsenic concentrations in postpartum toenail and immune cell subpopulations (n = 57<sup>*</sup>).
<p>Statistically significant associations are denoted in bold font. The beta values are the percent of changes in the relative immune cell numbers per doubling of arsenic exposure.</p