Effect of irreversible electroporation parameters and the presence of a metal stent on the electric field line pattern

The final ablation zone created with irreversible electroporation (IRE) depends on the size, shape and strength of the electric field that is influenced by several parameters. A profound understanding of the effect of IRE parameter alterations on the electric field are a prerequisite for a safe and effective treatment. Here, we demonstrate a semolina in castor oil model that enables visualization of the static electric field developed by a high-voltage generator between two needle-electrodes. We intuitively visualize the variation in electric field line pattern for selected IRE parameters; active needle length, inter-needle distance, applied voltage and presence of a nearby metal stent, by cameras in three dimensions. The observations were compared to and supported by two-dimensional numerical simulations of the electric field. Our semolina model visualizes the disturbance of the electric field by a metal stent, potentially leading to an incomplete tumour ablation between the needles. The reduction in electric field strength and the area at risk for incomplete tumour ablation are confirmed by the numerical simulations. The semolina model provides insight in the fundamental physics of the electric field, the effect of alterations in IRE parameter combinations and presence of a metal stent within the ablation zone

sj-pdf-1-tct-10.1177_15330338221125003 - Supplemental material for The Influence of Irreversible Electroporation Parameters on the Size of the Ablation Zone and Thermal Effects: A Systematic Review

Supplemental material, sj-pdf-1-tct-10.1177_15330338221125003 for The Influence of Irreversible Electroporation Parameters on the Size of the Ablation Zone and Thermal Effects: A Systematic Review by Annemiek M Hogenes, MSc, Christiaan G Overduin, PhD, Cornelis H Slump, PhD, Cornelis J H M van Laarhoven, MD, PhD, Jurgen J Fütterer, MD, PhD, Richard P G ten Broek, MD, PhD, and Martijn W J Stommel, MD, PhD in Technology in Cancer Research & Treatment</p