Time-delayed models of gene regulatory networks

We discuss different mathematical models of gene regulatory networks as relevant to the onset and development of cancer. After discussion of alternativemodelling approaches, we use a paradigmatic two-gene network to focus on the role played by time delays in the dynamics of gene regulatory networks. We contrast the dynamics of the reduced model arising in the limit of fast mRNA dynamics with that of the full model. The review concludes with the discussion of some open problems

Space missions to detect the cosmic gravitational-wave background

It is thought that a stochastic background of gravitational waves was produced during the formation of the universe. A great deal could be learned by measuring this Cosmic Gravitational-wave Background (CGB), but detecting the CGB presents a significant technological challenge. The signal strength is expected to be extremely weak, and there will be competition from unresolved astrophysical foregrounds such as white dwarf binaries. Our goal is to identify the most promising approach to detect the CGB. We study the sensitivities that can be reached using both individual, and cross-correlated pairs of space based interferometers. Our main result is a general, coordinate free formalism for calculating the detector response that applies to arbitrary detector configurations. We use this general formalism to identify some promising designs for a GrAvitational Background Interferometer (GABI) mission. Our conclusion is that detecting the CGB is not out of reach.Comment: 22 pages, 7 figures, IOP style, References Adde

Gravitational Waves from Mesoscopic Dynamics of the Extra Dimensions

Recent models which describe our world as a brane embedded in a higher dimensional space introduce new geometrical degrees of freedom: the shape and/or size of the extra dimensions, and the position of the brane. These modes can be coherently excited by symmetry breaking in the early universe even on ``mesoscopic'' scales as large as 1 mm, leading to detectable gravitational radiation. Two sources are described: relativistic turbulence caused by a first-order transition of a radion potential, and Kibble excitation of Nambu-Goldstone modes of brane displacement. Characteristic scales and spectral properties are estimated and the prospects for observation by LISA are discussed. Extra dimensions with scale between 10 \AA and 1 mm, which enter the 3+1-D era at cosmic temperatures between 1 and 1000 TeV, produce backgrounds with energy peaked at observed frequencies in the LISA band, between $10^{-1}$ and $10^{-4}$ Hz. The background is detectable above instrument and astrophysical foregrounds if initial metric perturbations are excited to a fractional amplitude of $10^{-3}$ or more, a likely outcome for the Nambu-Goldstone excitations.Comment: Latex, 5 pages, plus one figure, final version to appear in Phys. Rev. Let

Ruminant Nutrition and Production in the Tropics and Subtropics

Livestock Production/Industries,

A Bayesian Estimate of the Primordial Helium Abundance

We introduce a new statistical method to estimate the primordial helium abundance, Y_p from observed abundances in a sample of galaxies which have experienced stellar helium enrichment. Rather than using linear regression on metal abundance we construct a likelihood function using a Bayesian prior, where the key assumption is that the true helium abundance must always exceed the primordial value. Using a sample of measurements compiled from the literature we find estimates of Y_p between 0.221 and 0.236, depending on the specific subsample and prior adopted, consistent with previous estimates either from a linear extrapolation of the helium abundance with respect to metallicity, or from the helium abundance of the lowest metallicity HII region, I Zw 18. We also find an upper limit which is insensitive to the specific subsample or prior, and estimate a model-independent bound Y_p < 0.243 at 95% confidence, favoring a low cosmic baryon density and a high primordial deuterium abundance. The main uncertainty is not the model of stellar enrichment but possible common systematic biases in the estimate of Y in each individual HII region.Comment: 14 pages, latex, 3 ps figure

Collision of High Frequency Plane Gravitational and Electromagnetic Waves

We study the head-on collision of linearly polarized, high frequency plane gravitational waves and their electromagnetic counterparts in the Einstein-Maxwell theory. The post-collision space-times are obtained by solving the vacuum Einstein-Maxwell field equations in the geometrical optics approximation. The head-on collisions of all possible pairs of these systems of waves is described and the results are then generalised to non-linearly polarized waves which exhibit the maximum two degrees of freedom of polarization.Comment: Latex file, 17 pages, accepted for publication in International Journal of Modern Physics

Interferometers as Probes of Planckian Quantum Geometry

A theory of position of massive bodies is proposed that results in an observable quantum behavior of geometry at the Planck scale, $t_P$. Departures from classical world lines in flat spacetime are described by Planckian noncommuting operators for position in different directions, as defined by interactions with null waves. The resulting evolution of position wavefunctions in two dimensions displays a new kind of directionally-coherent quantum noise of transverse position. The amplitude of the effect in physical units is predicted with no parameters, by equating the number of degrees of freedom of position wavefunctions on a 2D spacelike surface with the entropy density of a black hole event horizon of the same area. In a region of size $L$, the effect resembles spatially and directionally coherent random transverse shear deformations on timescale $\approx L/c$ with typical amplitude $\approx \sqrt{ct_PL}$. This quantum-geometrical "holographic noise" in position is not describable as fluctuations of a quantized metric, or as any kind of fluctuation, dispersion or propagation effect in quantum fields. In a Michelson interferometer the effect appears as noise that resembles a random Planckian walk of the beamsplitter for durations up to the light crossing time. Signal spectra and correlation functions in interferometers are derived, and predicted to be comparable with the sensitivities of current and planned experiments. It is proposed that nearly co-located Michelson interferometers of laboratory scale, cross-correlated at high frequency, can test the Planckian noise prediction with current technology.Comment: 23 pages, 6 figures, Latex. To appear in Physical Review

A Class of Collisions of Plane Impulsive Light--Like Signals in General Relativity

We present a systematic study of collisions of homogeneous, plane--fronted, impulsive light--like signals which do not interact after head--on collision. For the head--on collision of two such signals, six real parameters are involved, three from each of the incoming signals. We find two necessary conditions to be satisfied by these six parameters for the signals to be non--interacting after collision. We then solve the collision problem in general when these necessary conditions hold. After collision the two signals focus each other at Weyl curvature singularities on each others signal front. Our family of solutions contains some known collision solutions as special cases.Comment: 14 pages, late

High-power operation of a K-band second harmonic gyroklystron

Amplification studies of a two-cavity second-harmonic gyroklystron are reported. A magnetron injection gun produces a 440 kV, 200–245 A, 1 μs beam with an average perpendicular-to-parallel velocity ratio slightly less than 1. The TE011 input cavity is driven near 9.88 GHz and the TE021 output cavity resonates near 19.76 GHz. Peak powers exceeding 21 MW are achieved with an efficiency near 21% and a large signal gain above 25 dB. This performance represents the current state of the art for gyroklystrons in terms of the peak power normalized to the output wavelength squared