On the design of a wireless multi-antenna monitoring system

In this paper we investigate the design of a wireless monitoring system. This system consists of several wireless monitoring units, each transmitting data collected from sensors. This data is received and processed at a central control unit. The typical operating environment poses several challenges. The channel’s delay spread is substantial and the distance between receiver and transmitter is in the order of 400 meters. In order to guarantee reliable communication, we combine multi-antenna techniques (spacetime block coding) with strong coding (LDPC codes). The cost and complexity of the monitoring units is kept low, and most of the processing is performed on the central control unit. We present a system design for the monitoring units and show simulation results

A Language and Toolset for the Synthesis and Efficient Simulation of Clock-Cycle-True Signal-Processing Algorithms

Optimal simulation speed and synthesizability are contradictory requirements for a hardware description language. This paper presents a language and toolset that enables both synthesis and fast simulation of fixed-point signal processing algorithms at the register-transfer level using a single system description. This is achieved by separate code generators for different purposes. Code-generators have been developed for fast simulation (using ANSI-C) and for synthesis (using VHDL). The simulation performance of the proposed approach has been compared with other known methods and turns out to be comparable in speed to the fastest among them

Implementation of a Combined OFDM-Demodulation and WCDMA-Equalization Module

For a dual-mode baseband receiver for the OFDMWireless LAN andWCDMA standards, integration of the demodulation and equalization tasks on a dedicated hardware module has been investigated. For OFDM demodulation, an FFT algorithm based on cascaded twiddle factor decomposition has been selected. This type of algorithm combines high spatial and temporal regularity in the FFT data-flow graphs with a minimal number of computations. A frequency-domain algorithm based on a circulant channel approximation has been selected for WCDMA equalization. It has good performance, low hardware complexity and a low number of computations. Its main advantage is the reuse of the FFT kernel, which contributes to the integration of both tasks. The demodulation and equalization module has been described at the register transfer level with the in-house developed Arx language. The core of the module is a pipelined radix-23 butterfly combined with a complex multiplier and complex divider. The module has an area of 0.447 mm2 in 0.18 ¿m technology and a power consumption of 10.6 mW. The proposed module compares favorably with solutions reported in literature

Molecular Imaging of Cardiovascular Disease

The ability to visualize morphology and function of the heart plays a central role in cardiology practice today. However, clinical tools to diagnose processes in an early phase on a molecular level in order to prevent dysmorphy or dysfunction are still lacking. There is a need for early diagnosis of molecular processes on a pre-disease level and the ability to monitor existing and novel treatments enabling personalized medicine. Molecular imaging is emerging in research and early clinical trials as a very promising approach in diagnosis and monitoring of heart disease. In this review we aim to discuss the potential of molecular imaging in cardiovascular disease

Phylogeny and taxonomy of the Ophiostoma piceae complex and the Dutch elm disease fungi

The Ophiostoma piceae complex forms a monophyletic group of insect-dispersed pyrenomycetes with synnemata (Pesotum) and micronematous (Sporothrix) synanamorphs. Other species of Ophios-toma outside of the O. piceae complex that form syn-nemata lack the Sporothrix state. The nine recognized species within the 0. piceae complex are delimited by synnema morphology, growth rate at 32 C, mating reactions and sequences of the internal transcribed spacer (ITS) region of the rDNA operon. Phyloge-netic analysis of the ITS region suggests two major clades in the complex, one that causes bluestain in primarily coniferous hosts and the other on primarily hardwood hosts. In the coniferous group are O. pi-ceae, O. canum, O. floccosum and the recently de-scribed O. setosum (anamorph Pesotum cupulatum sp. nov.). In the hardwood group are O. querci, O. caton-ianum, and the Dutch elm disease fungi: O. ulmi, O. novo-ulmi and O. himal-ulmi. Restriction fragment length polymorphisms of the ITS region are shown to be a convenient diagnostic tool for delimiting these species

Synthesis of Chiral Bisoxazoline Ligands: (3aR,3a'R,8aS,8a'S)-2,2'-(cyclopropane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole)

A. Bis((3aR,8aS)-3a,8a-dihydro-8H-indeno[1,2-d]oxazol-2-yl)methane (3) . An oven-dried 2-L three-necked, round-bottomed flask equipped with a 6.5 cm × 2.0 cm Teflon-coated elliptical stir bar is fitted with a thermometer, a reflux condenser and a rubber septum. The system is connected to a continuous nitrogen flow and then charged with (1R,2S)-(+)-cis-1-amino-2-indanol (1, 22.2 g, 149 mmol, 2.1 equiv), diethyl malonimidate dihydrochloride (2, 16.4 g, 71 mmol, 1 equiv), and 1 L of dichloromethane (Note 2). The system is heated to 45 °C (internal temperature 43 °C) under an atmosphere of nitrogen in an oil bath for 18 h, stirring at 600 rpm. Reaction progress is monitored by ¹H NMR (Note 3) (Figure 1)

Estimated Worldwide Mortality Attributed to Secondhand Tobacco Smoke Exposure, 1990-2016

Importance: The World Health Organization estimates that the 1 billion individuals who smoke worldwide contribute to the 880 000 secondhand smoke (SHS)-related deaths among individuals who do not smoke each year. A better understanding of the scale of harm of SHS to those who do not smoke could increase awareness of the consequences of smoking and help to design measures to protect individuals who do not smoke, especially children. Objective: To calculate the number of individuals who smoke associated with the death of 1 individual who died of SHS exposure both on a global scale and in various World Bank regions. Design, Setting, and Participants: In this cross-sectional epidemiologic assessment, data from Our World in Data were used to tabulate the number of individuals who smoke in each country and number of premature deaths related to SHS in that country from 1990 to 2016. The mean number of cigarettes consumed in all countries was also included in analyses. Data were collected for the following World Bank regions: North America, Latin America and the Caribbean, Europe and Central Asia, the Middle East and North Africa, sub-Saharan Africa, South Asia, and East Asia and the Pacific from 1990 and 2016. Statistical analysis was conducted in July 2019. Exposure: Secondhand smoke. Main Outcomes and Measures: The pack-year index, calculated as the number of pack-years associated with the death of 1 individual who does not smoke but was exposed to SHS, and the SHS index, calculated as the number of individuals who smoked for 24 years (ie, the mean duration of smoking) associated with the death of 1 individual who does not smoke. Results: Globally, the SHS index changed favorably, from 31.3 (95% CI, 30.6-32.0) individuals who smoked associated with the death of 1 individual who did not smoke in 1990 to 52.3 (95% CI, 51.2-53.5) individuals who smoked in 2016. There was a wide regional variation in the 2016 secondhand smoke index, from 42.6 (95% CI, 41.6-43.5) individuals who smoked in the Middle East and North Africa to 85.7 (95% CI, 83.8-87.7) individuals who smoked in North America. Worldwide, the pack-year index also changed favorably from 751.9 (95% CI, 736.3-770.7) pack-years associated with 1 death in 1990 to 1255.9 (95% CI, 1227.2-1284.4) pack-years in 2016. Conclu

Supporting Adolescents with Mental Health Problems in Secondary Education:Feasibility of a Supported Education Intervention

Mental health problems in adolescence can have a profound influence on school functioning, educational attainment and thus future societal participation. Supported education (SEd) is a potentially useful method for educational professionals to help adolescents with mental health problems in secondary school improve their functioning by stimulating collaboration, ownership, and participation. In this study, we examined the feasibility of SEd in secondary education by examining its acceptability, implementation, and preliminary effectiveness. We performed a mixed-methods study using quantitative data (questionnaires) and qualitative data (interviews) from educational professionals (EP) and adolescents, aged 13-17, about their experiences with a SEd intervention. Regarding the acceptability of the intervention, three main themes emerged: (a) structure, (b) autonomy, and (c) applicability of the intervention. Themes regarding the implementation were: (a) lack of time, (b) personal attitude, (c) mastery, and (d) complexity of the school environment. The findings show that, for those that followed the intervention, SEd is a promising approach to support adolescents with mental health problems to improve their functioning and participation in school. Further research is needed on the effectiveness of the intervention

Diversity-Oriented Enzymatic Synthesis of Cyclopropane Building Blocks

While biocatalysis is increasingly incorporated into drug development pipelines, it is less commonly used in the early stages of drug discovery. By engineering a protein to produce a chiral motif with a derivatizable functional handle, biocatalysts can be used to help generate diverse building blocks for drug discovery. Here we show the engineering of two variants of Rhodothermus marinus nitric oxide dioxygenase (RmaNOD) to catalyze the formation of cis- and trans-diastereomers of a pinacolboronate-substituted cyclopropane which can be readily derivatized to generate diverse stereopure cyclopropane building blocks

Diversity-Oriented Enzymatic Synthesis of Cyclopropane Building Blocks

While biocatalysis is increasingly incorporated into drug development pipelines, it is less commonly used in the early stages of drug discovery. By engineering a protein to produce a chiral motif with a derivatizable functional handle, biocatalysts can be used to help generate diverse building blocks for drug discovery. Here we show the engineering of two variants of Rhodothermus marinus nitric oxide dioxygenase (RmaNOD) to catalyze the formation of cis- and trans-diastereomers of a pinacolboronate-substituted cyclopropane which can be readily derivatized to generate diverse stereopure cyclopropane building blocks