All-optical wavelength conversion using mode switching in InP microdisc laser

Wavelength conversion using an indium phosphide based microdisc laser (MDL) heterogeneously integrated on a silicon-on-insulator waveguide is reported. Several lasing modes are present within the disc cavity, between which wavelength conversion can be performed by mode switching and spectral filtering. For the first time, low-power wavelength up- and downconversion using one single MDL is demonstrated. Operation with a bit error rate below 10(-9) at 2.5 Gbit/s and operation below the forward-error-correction limit of 10(-3) at 10 Gbit/s are shown without the use of additional seeding beams

Overview of the EU FP7-project HISTORIC

HISTORIC aims to develop and test complex photonic integrated circuits containing a relatively large number of digital photonic elements for use in e.g. all-optical packet switching. These photonic digital units are all-optical flip-flops based on ultra compact laser diodes, such as microdisk lasers and photonic crystal lasers. These lasers are fabricated making use of the heterogeneous integration of InP membranes on top of silicon on insulator (SOI) passive optical circuits. The very small dimensions of the lasers are, at least for some approaches, possible because of the high index contrast of the InP membranes and by making use of the extreme accuracy of CMOS processing. All-optical flip-flops based on heterogeneously integrated microdisk lasers with diameter of 7.5 mu m have already been demonstrated. They operate with a CW power consumption of a few mW and can switch in 60ps with switching energies as low as 1.8 fJ. Their operation as all-optical gate has also been demonstrated. Work is also on-going to fabricate heterogeneously integrated photonic crystal lasers and all-optical flip-flops based on such lasers. A lot of attention is given to the electrical pumping of the membrane InP-based photonic crystal lasers and to the coupling to SOI wire waveguides. Optically pumped photonic crystal lasers coupled to SOI wires have been demonstrated already. The all-optical flip-flops and gates will be combined into more complex photonic integrated circuits, implementing all-optical shift registers, D flip-flops, and other all-optical switching building blocks. The possibility to integrate a large number of photonic digital units together, but also to integrate them with compact passive optical routers such as AWGs, opens new perspectives for the design of integrated optical processors or optical buffers. The project therefore also focuses on designing new architectures for such optical processing or buffer chips

A low-power high-speed InP microdisk modulator heterogeneously integrated on a SOI waveguide

We report on the modulation characteristics of indium phosphide (InP) based microdisks heterogeneously integrated on a silicon–on–insulator (SOI) waveguide. We present static extinction ratios and dynamic operation up to 10 Gb/s. Operation with a bit–error rate below 1 × 10-9 is demonstrated at 2.5, 5.0 and 10.0 Gb/s and the performance is compared with that of a commercial modulator. Power penalties are analyzed with respect to the pattern length. The power consumption is calculated and compared with state–of–the–art integrated modulator concepts. We demonstrate that InP microdisk modulators combine low–power and low–voltage operation with low footprint and high–speed. Moreover, the devices can be fabricated using the same technology as for lasers, detectors and wavelength converters, making them very attractive for co–integration

Compact InP-on-SOI microdisks used as high-speed modulators and photo detectors

We demonstrate for the first time that a single compact, electrically driven indium phosphide based microdisk heterogeneously integrated on a silicon-on-insulator waveguide can be used as both a high-speed modulator and photo detector. We demonstrate high-speed operation up to 10 Gb/s and present bit-error rate results of both operation modes.</p

Compact InP-on-SOI microdisks used as high-speed modulators and photo detectors

We demonstrate for the first time that a single compact, electrically driven indium phosphide based microdisk heterogeneously integrated on a silicon-on-insulator waveguide can be used as both a high-speed modulator and photo detector. We demonstrate high-speed operation up to 10 Gb/s and present bit-error rate results of both operation modes

High-speed direct-modulation of InP microdisk lasers

\u3cp\u3eWe demonstrate for the first time high-speed direct-modulation of InP microdisk lasers by exploiting longitudinal mode competition. High-speed operation is demonstrated by means of S\u3csub\u3e21\u3c/sub\u3e and PRBS modulation. We show open eye diagrams and bit-error rates up to 10 Gb/s.\u3c/p\u3

A single InP-on-SOI microdisk for high-speed half-duplex on-chip optical links

We demonstrate for the first time that a single compact, electrically contacted indium phosphide based microdisk heterogeneously integrated on a silicon–on–insulator waveguide can be used as both a high-speed modulator and photo detector. We demonstrate high-speed operation up to 10 Gb/s and present bit-error rate results of both operation modes

ABC Transporters B1, C1 and G2 Differentially Regulate Neuroregeneration in Mice

Background: ATP-binding cassette (ABC) transporters are essential regulators of organismic homeostasis, and are particularly important in protecting the body from potentially harmful exogenous substances. Recently, an increasing number of in vitro observations have indicated a functional role of ABC transporters in the differentiation and maintenance of stem cells. Therefore, we sought to determine brain-related phenotypic changes in animals lacking the expression of distinct ABC transporters (ABCB1, ABCG2 or ABCC1). Methodology and Principal Findings: Analyzing adult neurogenesis in ABC transporter-deficient animals in vivo and neuronal stem/progenitor cells in vitro resulted in complex findings. In vivo, the differentiation of neuronal progenitors was hindered in ABC transporter-deficient mice (ABCB1 0/0) as evidenced by lowered numbers of doublecortin + (236%) and calretinin + (237%) cells. In vitro, we confirmed that this finding is not connected to the functional loss of single neural stem/ progenitor cells (NSPCs). Furthermore, assessment of activity, exploratory behavior, and anxiety levels revealed behavioral alterations in ABCB1 0/0 and ABCC1 0/0 mice, whereas ABCG2 0/0 mice were mostly unaffected. Conclusion and Significance: Our data show that single ABC transporter-deficiency does not necessarily impair neuronal progenitor homeostasis on the single NSPC level, as suggested by previous studies. However, loss of distinct ABC transporters impacts global brain homeostasis with far ranging consequences, leading to impaired neurogenic functions i