PROTECTIVE ROLE OF POMEGRANATE JUICE BLENDED WITH WHEATGRASS AND LEMON EXTRACTS FOR RELIEVE CARBOHYDRATE INTOLERANCE

Characteristics and protective effect of pomegranate juice (PJ), lemon juice (LJ), wheatgrass juice (WGJ) and their functional blends were evaluated. Total phenolics (TP), flavonoids (TF) content as well as free radical scavenging activity were determined. Meanwhile, total acidity, pH values were determined and the organoleptic attributes were evaluated. Also, the protective effect of functional blending juice against carbohydrate intolerance in patients was investigated by hydrogen breath test.  The results revealed that the WGJ are low acidic in nature. While, the PJ and LJ showed high acidity which raised the total acidity in the functional blending juice. PJ had high content of total phenolics 17.45 mg/ml followed by 5.85 mg/ml for functional blending juice. While, the LJ showed high acidity which raised the total acidity in the in the functional blending juice. PJ had high content of total phenolics 17.45 mg/ml followed by 13.25 mg/ml for functional blending juice. While, significant increase in the TF 22.15 mg/ml in the wheatgrass juice followed by functional blending juice 5.70 mg/ml significant increase in the TF 25.25 mg /ml in the functional blending juice followed by 22.15 mg/ml for wheatgrass juice. Whereas, the results showed that functional blending juice recorded the highest antioxidant activity, which revealed great free radical scavenging activity 98.16%. Depending on sensory evaluation, the proportions of fourth blend WGJ: PJ: LJ in ratio 20:70:10 was most preferred for consumption by the panelists compared to other blending ratios.  After one month for patients group treated by functional blending juice at blinds ratio (WGJ 20: PJ 70: LJ 10), showed a significant decrease in the concentration of the hydrogen level in the exhalation air to reach a significant level of the control patients group, indicating the ability of the active compounds in functional blending juice to relieve the problems of carbohydrate intolerance. Accordingly, healthy promoting beverages can be produced by addition blending of pomegranate juice, lemon juice and wheatgrass juice

Venous-derived angioblasts generate organ-specific vessels during embryonic development

Formation and remodeling of vascular beds are complex processes orchestrated by multiple signaling pathways. While it is well accepted that vessels of a particular organ display specific features that enable them to fulfill distinct functions, the embryonic origins of tissue-specific vessels, as well as the molecular mechanisms regulating their formation, are poorly understood. The subintestinal plexus of the zebrafish embryo comprises vessels that vascularize the gut, liver and pancreas, and as such represents an ideal model to investigate the early steps of organ-specific vessel formation. Here we show that both arterial and venous components of the subintestinal plexus originate from a pool of specialized angioblasts residing in the floor of the Posterior Cardinal Vein (PCV). Using live imaging of zebrafish embryos, in combination with photoconvertable transgenic reporters, we demonstrate that these angioblasts undergo two phases of migration and differentiation. Initially, a subintestinal vein (SIV) forms and expands ventrally through a bone morphogenetic protein (BMP)-dependent step of collective migration. Concomitantly, a VEGF-dependent shift in the directionality of migration, coupled to the upregulation of arterial markers is observed, which culminates with the generation of the supraintestinal artery (SIA). Altogether our results establish the zebrafish subintestinal plexus as an advantageous model for the study of organ-specific vessel development, and provide new insights into the molecular mechanisms controlling its formation. More broadly, our findings suggest that PCV-specialized angioblasts contribute not only to the formation of the early trunk vasculature, but also to the establishment of late forming-, tissue specific vascular beds

Venous-derived angioblasts generate organ-specific vessels during zebrafish embryonic development

open11siFormation and remodeling of vascular beds are complex processes orchestrated by multiple signaling pathways. Although it is well accepted that vessels of a particular organ display specific features that enable them to fulfill distinct functions, the embryonic origins of tissue-specific vessels and the molecular mechanisms regulating their formation are poorly understood. The subintestinal plexus of the zebrafish embryo comprises vessels that vascularize the gut, liver and pancreas and, as such, represents an ideal model in which to investigate the early steps of organ-specific vessel formation. Here, we show that both arterial and venous components of the subintestinal plexus originate from a pool of specialized angioblasts residing in the floor of the posterior cardinal vein (PCV). Using live imaging of zebrafish embryos, in combination with photoconvertable transgenic reporters, we demonstrate that these angioblasts undergo two phases of migration and differentiation. Initially, a subintestinal vein forms and expands ventrally through a Bone Morphogenetic Protein-dependent step of collective migration. Concomitantly, a Vascular Endothelial Growth Factor-dependent shift in the directionality of migration, coupled to the upregulation of arterial markers, is observed, which culminates with the generation of the supraintestinal artery. Together, our results establish the zebrafish subintestinal plexus as an advantageous model for the study of organ-specific vessel development and provide new insights into the molecular mechanisms controlling its formation. More broadly, our findings suggest that PCV-specialized angioblasts contribute not only to the formation of the early trunk vasculature, but also to the establishment of late-forming, tissue-specific vascular beds.openHen, Gideon; Nicenboim, Julian; Mayseless, Oded; Asaf, Lihee; Shin, Masahiro; Busolin, Giorgia; Hofi, Roy; Almog, Gabriella; Tiso, Natascia; Lawson, Nathan D.; Yaniv, KarinaHen, Gideon; Nicenboim, Julian; Mayseless, Oded; Asaf, Lihee; Shin, Masahiro; Busolin, Giorgia; Hofi, Roy; Almog, Gabriella; Tiso, Natascia; Lawson, Nathan D.; Yaniv, Karin

JUDICIAL REVIEW SATU ATAP DI MAHKAMAH KONSTITUSI SEBAGAI REFLEKSI TERHADAP PROBLEMATIKA DAN TANTANGAN KEKUASAAN KEHAKIMAN DI INDONESIA

Judicial review merupakan suatu upaya hukum agar dapat keluar dari peroalan regulasi yang dihasilkan pembentuk uu dengan kualitas rendah.  namun demikian, penyelenggaraan judicial review pada praktiknya selama ini dapat memunculkan suatu persoalan hukum. Penyebabnya di antaranya adalah pembagian kewenangan dalam praktik judicial review oleh MK dan MA untuk melakukan judicial review. Disamping hal di atas, beberapa alasan pengujian satu atap di Mahkamah Konstitusi didasari  beberapa alasan, di antaranya mengurungi beban menumpuk di Mahkamah Agung mengingat MA tidak hanya sekedar menguji regulasi dibawah uu, kasasi, peninjauan kembali kasus pidana dan perdata serta TUN juga menjadi bagian dari kewenangan MA yang tidak terpisahkan, kepastian hukum serta keadilan bagi masyarakat, efisiensi dan efektifitas dapat diwujudkan bila dilakukan dalam satu atap di MK. Praktik judicial review di Mahkamah Konstitusi sangat terbuka bila di bandingkan MA. Karenanya judicial review satu di MK Urgent untuk dilaksanakan. Tulisan ini mengkaji dengan konkrit persoalan dualisme judicial review dalam perspektif negara hukum serta ugensi judicial review satu pintu di MK sebagai solusi atas problematika di atas

Formulasi Kewenangan Penyadapan Komisi Pemberantasan Korupsi Dalam Upaya Pemberantasan Tindak Pidana Korupsi di Indonesia

Fiat justitia ruat caelum, artinya hendaklah keadilan ditegakkan, walaupun langit akan runtuh. Kalimat ini diucapkan oleh pemangku kekuasaan Romawi, Lucius Calpurnius Piso Caesoninus (43 SM). Komisi pemberantasan Korupsi (KPK) adalah lembaga yang diharapkan oleh seluruh rakyat Indonesia untuk mampu memberantas tindak pidana korupsi yang akibatnya sangat merugikan negara khususnya keuangan negara. Dalam Undang-undang KPK (Pasal 12 (1) huruf a), lembaga ini diberi kewenangan melakukan penyadapan dalam melakukan penyelidikan, penyidikan dan penuntutan tindak pidana korupsi. Dengan diberikannya wewenang penyadapan kepada KPK oleh undang-undang maka memudahkan KPK dalam memberantas tindak pidana korupsi, hal ini terbukti dengan banyaknya kasus korupsi dinegeri ini yang dituntaskan oleh KPK. Namun akhir-akhir ini kewenangan penyadapan tersebut dibatasi oleh Undang-undang KPK yang baru, yaitu Undang-undang Nomor 19 Tahun 2019 Tentang Perubahan Kedua Atas Undang-Undang Nomor 30 Tahun 2002 Tentang Komisi Pemberantasan Tindak Pidana Korupsi dimana lembaga KPK dalam melakukan penyadapan harus terlebih dahulu mendapatkan izin dari dewan pengawas yang dibentuk oleh DPR dan Presiden. Hal ini memicu beberapa hal yang menyebabkan proses penyadapan menjadi terhambat atau bahkan tidak bisa dilakukan secara leluasa oleh KPK. &nbsp

Evaluation of limbal transplantation in eyes with bilateral severe ocular surface damage secondary to chemical injury

Abdel Hamid El-Hofi, Hany Ahmed Helaly Department of Ophthalmology, Faculty of Medicine, Alexandria University, Alexandria, Egypt Purpose: To evaluate the outcome of limbal transplantation in eyes with bilateral severe ocular surface damage secondary to chemical injury.Patients and methods: This was a retrospective case series that included 20 patients who had undergone living related limbal transplantation due to the presence of bilateral severe stem cell deficiency resulting from chemical injury. Medical records of the selected patients were reviewed. The following data were recorded and analyzed: gender; age at the time of the surgery; duration of follow-up; corrected distance visual acuity (CDVA); symptoms; intraocular pressure (IOP); any complications; postoperative treatment; and other surgical procedures needed.Results: The mean age of the included patients was 27.4±9.3 years. The causative agent was an alkali in 14 patients. Fifteen patients (75%) had a stable ocular surface (ie, complete corneal re-epithelization and resolution of postoperative inflammation) after the first limbal transplantation, while the other five patients (25%) needed regrafting. As regards the IOP; five patients (25%) needed Ahmed’s valve implantation to control the IOP. Other surgical procedures needed were penetrating keratoplasty (PKP) in three patients (15%), cataract surgery in six patients (30%), and lid surgery in one patient (5%).Conclusion: In conclusion, living related conjunctival limbal allograft transplantation, especially when combined with amniotic membrane transplantation, yielded good results in the management of cases with bilateral severe chemical eye injuries. Keywords: living related, limbal stem cells, transplantation, chemical injur