Did You See That? A Study of Change Blindness

OBJECTIVES Increasing concern has been expressed regarding the safety implications of drivers attempting to use in-vehicle devices other than cellular phones while driving. To address this issue, the effect of cognitive load on visual attention merits investigation. Strayer and Johnston (2001) found invehicle system use, specifically cell-phone use, disrupts performance by diverting attention to an engaging cognitive context other than the one immediately associated with driving. Recarte and Nunes (2000) demonstrated that scanning patterns and visual attention can be disrupted by cognitive load. In-vehicle systems can increase the cognitive load of the driver, making it more difficult for the driver to direct attention to the visual scene. The change blindness phenomenon may be useful way to investigate how cognitive load affects attention. Change blindness is the inability to detect scene change when the change occurs in conjunction with an action such as a blink (O’Regan, Deubel, Clark, and Rensink, 2000), eye movement (Wallis and Bulthoff, 2000), or an image that masks the onset of the change (Simons and Levin, 1998). The aim of this experiment was to study the effect of cognitive loading on individuals’ ability to detect change in their visual environment using a speech-based email task. METHODS Twenty participants completed a series of five conditions. In two of these conditions the participants did just one task: either the e-mail task or the visual search task. In the other three conditions participants completed the e-mail and the visual search tasks concurrently. In one email task condition the speech recognition system worked perfectly. In a second condition, speech recognition errors caused the wrong menu item to be selected. In a third condition, speech recognition errors caused the user to be displaced to the wrong menu. In three of the visual search task conditions participants were asked to identify changes that occurred in visual scenes, using the Rensink, et al. (1997) flicker paradigm while navigating a speech-based e-mail system. The visual task presented a series of four displays. These were: an unaltered image (300ms), a gray screen (1150ms), a second image (300ms), and a gray screen (1150ms). The second image was either the unaltered image or an image altered by the addition or removal of an element. The remaining conditions for both the e-mail task and visual search task were labeled as baseline. The baseline measurements were used to evaluate the effects of cognitive load on detection of scene changes. RESULTS Analyses showed that detection of scene changes took significantly longer when participants were cognitively loaded with the e-mail task (mean 5.05) compared to when they were not (mean 4.35), F(3,67)=11.13, p< 0.0001. Analyses also showed participants took significantly longer to determine that the scene had not changed (mean 5.99) than to detect a change had occurred (mean 3.72), F(2,67)=271.95, p <0.0001. Scene detection accuracy was significantly reduced when participants were cognitively loaded with the e-mail task, F(3,67)=5.47, p0.0010. Speech recognition errors introduced by the researcher had little effect on times to determine scene changes as well as time to detect meaningful and non-meaningful scene changes. CONCLUSION The results of this study demonstrate that change detection is sensitive to cognitive load and that endogenous control of visual attention may have been affected by the introduction of the e-mail system. It also shows that the paradigm of scenes with and without changes seems to be a promising and sensitive tool for measuring the effects of cognitive load on an individual’s ability to detect change. REFERENCES O\u27Regan, J.K., H. Deubel, J.J. Clark, & R.A. Rensink. (2000). Picture changes during blinks: Looking without seeing and seeing without looking. Visual Cognition 7(1-3), 191-211. Recarte, M.A. & Nunes, L.M. (2000). Effects of verbal and spatial imagery tasks to eye fixations while driving. Journal of Experimental Psychology: Applied,6, 31-43 Rensink, R.A., Oregan, J.K., & Clark, J.J. (1997). To see or not see: The need for attention to perceive changes in scenes. Psychological Sciences, 8, 368-373 Simons, D.J. and D.T. Levin. (1998). Failure to detect changes to people during a real-world interaction. Psychonomic Bulletin & Review 5(4), 644-649. Strayer, D.L. & Johnston, W.A. (2001). Driven to distraction: Dual-task studies of simulated driving and conversing on a cellular phone. Psychological Science, 12, 462-466 Wallis, G. and H. Bulthoff. (2000). What’s scene and not seen: Influences of movement and task upon what we see. Visual Cognition 7(1-3), 175-190

Sorting Guilty Minds

Because punishable guilt requires that bad thoughts accompany bad acts, the Model Penal Code (MPC) typically requires that jurors infer the past mental state of a criminal defendant. More specifically, jurors must sort that mental state into one of four specific categories - purposeful, knowing, reckless, or negligent - which in turn defines the nature of the crime and the extent of the punishment. The MPC therefore assumes that ordinary people naturally sort mental states into these four categories with a high degree of accuracy, or at least can reliably do so when properly instructed. It also assumes that ordinary people will order these categories of mental state, by increasing amount of punishment, in the same severity hierarchy that the MPC prescribes. The MPC, now turning 50 years old, has previously escaped the scrutiny of comprehensive empirical research on these assumptions underlying its culpability architecture. Our new empirical studies, reported here, find that most of the mens rea assumptions embedded in the MPC are reasonably accurate as a behavioral matter. Even without the aid of the MPC definitions, subjects were able to regularly and accurately distinguish among purposeful, negligent, and blameless conduct. Nevertheless, our subjects failed to distinguish reliably between knowing and reckless conduct. This failure can have significant sentencing consequences in some types of crimes, especially homicide

The Orbit and Occultations of KH 15D

The unusual flux variations of the pre-main-sequence binary star KH 15D have been attributed to occultations by a circumbinary disk. We test whether or not this theory is compatible with newly available data, including recent radial velocity measurements, CCD photometry over the past decade, and photographic photometry over the past 50 years. We find the model to be successful, after two refinements: a more realistic motion of the occulting feature, and a halo around each star that probably represents scattering by the disk. The occulting feature is exceptionally sharp-edged, raising the possibility that the dust in the disk has settled into a thin layer, and providing a tool for fine-scale mapping of the immediate environment of a T Tauri star. However, the window of opportunity is closing, as the currently visible star may be hidden at all orbital phases by as early as 2008.Comment: To appear in ApJ [16 pages, 13 figures

Capturing Driver Response to In-Vehicle Human-Machine Interface Technologies Using Facial Thermography

Measuring driver response to in-vehicle human-machine interface (HMI) systems is critical for the automotive design and evaluation process. Physiological measures provide a useful complement to performance-based and subjective measures because they promise an estimate of the affective response of drivers to an in-vehicle system in a way that requires no overt response by the driver. This research explored how facial temperature might reflect the drivers’ response to the demands they confront when interacting with in-vehicle systems. Sixteen drivers completed a series of in-vehicle tasks while driving in a simulator. Facial temperature was measured using an infrared camera. The analyses focus on how the thermal data, aggregated over four facial regions, correlated with both measures of driving performance and subjective ratings of workload and frustration. Facial temperature measures correlated with more driving performance measures of longitudinal control than lateral control, suggesting that thermal measures are sensitive to different cognitive processes than are typically assessed by measures of steering and lane position. Thermal measures aggregated over a 15-second window correlated with subjective ratings. Unlike other measures typically used to evaluate in-vehicle systems that are aggregated over long time windows, thermal measures have temporal specificity and might be able to identify specific interactions that increase workload and frustration. No single facial area or summary measure emerged as the best indicator of driver response; rather, composite measures of facial temperature could be developed that offer a more complete profile of driver response

Ultra-low-loss Polaritons in Isotopically Pure Materials: A New Approach

Conventional optical components are limited to size-scales much larger than the wavelength of light, as changes in the amplitude, phase and polarization of the electromagnetic fields are accrued gradually along an optical path. However, advances in nanophotonics have produced ultra-thin, co-called "flat" optical components that beget abrupt changes in these properties over distances significantly shorter than the free space wavelength. While high optical losses still plague many approaches, phonon polariton (PhP) materials have demonstrated long lifetimes for sub-diffractional modes in comparison to plasmon-polariton-based nanophotonics. We experimentally observe a three-fold improvement in polariton lifetime through isotopic enrichment of hexagonal boron nitride (hBN). Commensurate increases in the polariton propagation length are demonstrated via direct imaging of polaritonic standing waves by means of infrared nano-optics. Our results provide the foundation for a materials-growth-directed approach towards realizing the loss control necessary for the development of PhP-based nanophotonic devices

Immunotherapy Approaches for the Treatment of Diffuse Midline Gliomas

Diffuse midline gliomas (DMG) are a highly aggressive and universally fatal subgroup of pediatric tumors responsible for the majority of childhood brain tumor deaths. Median overall survival is less than 12 months with a 90% mortality rate at 2 years from diagnosis. Research into the underlying tumor biology and numerous clinical trials have done little to change the invariably poor prognosis. Continued development of novel, efficacious therapeutic options for DMGs remains a critically important area of active investigation. Given that DMGs are not amenable to surgical resection, have only limited response to radiation, and are refractory to traditional chemotherapy, immunotherapy has emerged as a promising alternative treatment modality. This review summarizes the various immunotherapy-based treatments for DMG as well as their specific limitations. We explore the use of cell-based therapies, oncolytic virotherapy or immunovirotherapy, immune checkpoint inhibition, and immunomodulatory vaccination strategies, and highlight the recent clinical success of anti-GD2 CAR-T therapy in diffuse intrinsic pontine glioma (DIPG) patients. Finally, we address the challenges faced in translating preclinical and early phase clinical trial data into effective standardized treatment for DMG patients

Genome sequencing and analysis of the paclitaxelproducing endophytic fungus \u3cem\u3ePenicillium aurantiogriseum\u3c/em\u3e NRRL 62431

Background Paclitaxel (Taxol™) is an important anticancer drug with a unique mode of action. The biosynthesis of paclitaxel had been considered restricted to the Taxus species until it was discovered in Taxomyces andreanae, an endophytic fungus of T. brevifolia. Subsequently, paclitaxel was found in hazel (Corylus avellana L.) and in several other endophytic fungi. The distribution of paclitaxel in plants and endophytic fungi and the reported sequence homology of key genes in paclitaxel biosynthesis between plant and fungi species raises the question about whether the origin of this pathway in these two physically associated groups could have been facilitated by horizontal gene transfer. Results The ability of the endophytic fungus of hazel Penicillium aurantiogriseum NRRL 62431 to independently synthesize paclitaxel was established by liquid chromatography-mass spectrometry and proton nuclear magnetic resonance. The genome of Penicillium aurantiogriseum NRRL 62431 was sequenced and gene candidates that may be involved in paclitaxel biosynthesis were identified by comparison with the 13 known paclitaxel biosynthetic genes in Taxus. We found that paclitaxel biosynthetic gene candidates in P. aurantiogriseum NRRL 62431 have evolved independently and that horizontal gene transfer between this endophytic fungus and its plant host is unlikely. Conclusions Our findings shed new light on how paclitaxel-producing endophytic fungi synthesize paclitaxel, and will facilitate metabolic engineering for the industrial production of paclitaxel from fungi