Determinants of Vessel Targeting in Vasculitis

Studies of autoimmune diseases have not yet elucidated why certain organs or vessels become the objects of injury while others are spared. This paper will explore the hypothesis that important differences exist in regions of the aorta that determine vulnerability to diseases, such as atherosclerosis, aortitis, giant cell arteritis and Takayasu's disease. The reader is invited to reassess; (1) whether the aorta is indeed a single homogeneous structure, and (2) whether the initial stage of aortitis (and indeed other diseases considered “autoimmune”) may be primarily due to acquired alterations of substrate, that influence unique immune profiles, which by themselves may not be pathogenic. Disease susceptibility and patterns are influenced by many factors that are inborn and acquired. Examples include genetic background, gender, ethnicity, aging, prior and concomitant illnesses, habits, diet, toxin and environmental exposures. Studies of vascular diseases must assess how such variables may affect regional differences in endothelial cells, subendothelial matrix, vascular smooth muscle and the response of each to a variety of stimuli

Eliminating Fruit and Vegetable Planting Restrictions: How Would Markets Be Affected?

Eighty-nine percent of American households were food secure throughout the entire year in 2005, meaning that they had access, at all times, to enough food for an active, healthy life for all household members. The remaining households were food insecure at least some time during that year. The prevalence of food insecurity declined from 11.9 percent of households in 2004 to 11.0 percent in 2005, while the prevalence of very low food security remained unchanged at 3.9 percent. This report, based on data from the December 2005 food security survey, provides the most recent statistics on the food security of U.S. households, as well as on how much they spent for food and the extent to which food-insecure households participated in Federal and community food assistance programs. Survey responses indicate that the typical food-secure household in the U.S. spent 34 percent more on food than the typical food-insecure household of the same size and household composition. Just over one-half of all food-insecure households participated in one or more of the three largest Federal food assistance programs during the month prior to the survey. About 22 percent of food-insecure households—3.5 percent of all U.S. households—obtained emergency food from a food pantry at some time during the year.Food security, food insecurity, food spending, food pantry, hunger, soup kitchen, emergency kitchen, material well-being, Food Stamp Program, National School, Crop Production/Industries,