Automated analysis of blood pressure measurements (Korotkov sound)

Automatic system for noninvasive measurements of arterial blood pressure is described. System uses Korotkov sound processor logic ratios to identify Korotkov sounds. Schematic diagram of system is provided to show components and method of operation

Recent extensions to the free-vortex-sheet theory for expanded convergence capability

A new version of the free vortex sheet formulation is presented which has greatly improved convergence characteristics for a broad range of geometries. The enhanced convergence properties were achieved largely with extended modeling capabilities of the leading edge vortex and the near field trailing wake. Results from the new code, designated FVS-1, are presented for a variety of configurations and flow conditions with emphasis on vortex flap applications

Apparatus and method for processing Korotkov sounds

A Korotkov sound processor, used in a noninvasive automatic blood measuring system where the brachial artery is occluded by an inflatable cuff, is disclosed. The Korotkoff sound associated with the systolic event is determined when the ratio of the absolute value of a voltage signal, representing Korotkov sounds in the range of 18 to 26 Hz to a maximum absolute peak value of the unfiltered signals, first equals or exceeds a value of 0.45. Korotkov sound associated with the diastolic event is determined when a ratio of the voltage signal of the Korotkov sounds in the range of 40 to 60 Hz to the absolute peak value of such signals within a single measurement cycle first falls below a value of 0.17. The processor signals the occurrence of the systolic and diastolic events and these signals can be used to control a recorder to record pressure values for these events

Anthropometric changes and fluid shifts

Several observations of body size, shape, posture, and configuration were made to document changes resulting from direct effects of weightlessness during the Skylab 4 mission. After the crewmen were placed in orbit, a number of anatomical and anthropometric changes occurred including a straightening of the thoracolumbar spine, a general decrease in truncal girth, and an increase in height. By the time of the earliest in-flight measurement on mission day 3, all crewmen had lost more than two liters of extravascular fluid from the calf and thigh. The puffy facies, the bird legs effect, the engorgement of upper body veins, and the reduced volume of lower body veins were all documented with photographs. Center-of-mass measurements confirmed a fluid shift cephalad. This shift remained throughout the mission until recovery, when a sharp reversal occurred; a major portion of the reversal was completed in a few hours. The anatomical changes are of considerable scientific interest and of import to the human factors design engineer, but the shifts of blood and extravascular fluid are of more consequence. It is hypothesized that the driving force for the fluid shift is the intrinsic and unopposed lower limb elasticity that forces venous blood and then other fluid cephalad

Skylab medical data evaluation program (SMEDEP)

A day-by-day summary of selected data collected during the experiment is presented. The clinical and environmental data are presented in a mission-day format along with a tabulation of biomedical measurements whose values exceed three standard deviations from the preflight measurements

Determination of cardiac size from chest roentgenograms following Skylab missions

Decreased cardiothoracic transverse diameter ratios following Mercury, Gemini and Apollo space flights have been reported previously. To evaluate further changes in cardiac size, standard posteroanterior chest films in systole and diastole were obtained before flight and within a few hours after recovery on each of the Skylab astronauts. Postflight chest X-rays were visually compared to the preflight roentgenograms for possible changes in pulmonary vasculature, lung parenchyma, bony or soft tissue structures. From these roentgenograms the following measurements were obtained: cardiac and thoracic transverse diameters, cardiothoracic transverse diameter ratio, cardiac area from the product of both diagonal diameters, cardiac silhouette area by planimetry, thoracic cage area and cardiothoracic area ratio. The postflight frontal cardiac silhouette sizes were significantly decreased when compared with the respective preflight values (P0.05 or 0.01). The observed changes are thought to be related to postflight decrease in the intracardiac chamber volume

Spectral analysis of skeletal muscle changes resulting from 59 days of weightlessness in Skylab 2

During stressful exercise of the m. gastrocnemius, preflight and postflight surface electromyograms (EMG) were taken from each of the Skylab II astronauts. Measurements on the muscle were made once 5 days before launch, and four times postflight on recovery day, 4 days after recovery, 16 days after recovery and 29 days after recovery. It was hypothesized that the disused gastrocnemius would exhibit dysfunction characteristics similar to those found in laboratory studies on disuse and of pathologically astrophied muscle, and that physical stress would be associated with heightened fatigability in the muscle. Both hypotheses were sustained. The results showed significant shifts of the predominant frequency of the gastrocnemius into higher than normal bands which suggests a relationship between muscle disuse characteristics and pathologic dysfunction characteristics. It was concluded that the spectrally analyzed EMG is a sensitive measure of muscle dsyfunction that is associated with disuse. Antigravity muscles exhibit heightened susceptibility to fatigue when subjected to lengthy weightlessness

Concepts of Integration for UAS Operations in the NAS

One of the major challenges facing the integration of Unmanned Aircraft Systems (UAS) in the National Airspace System (NAS) is the lack of an onboard pilot that can comply with the legal requirement identified in the US Code of Federal Regulations (CFR) that pilots see and avoid other aircraft. UAS will be expected to demonstrate the means to perform the function of see and avoid while preserving the safety level of the airspace and the efficiency of the air traffic system. This paper introduces a Sense and Avoid (SAA) concept for integration of UAS into the NAS that is currently being developed by the National Aeronautics and Space Administration (NASA) and identifies areas that require additional experimental evaluation to further inform various elements of the concept. The concept design rests on interoperability principles that take into account both the Air Traffic Control (ATC) environment as well as existing systems such as the Traffic Alert and Collision Avoidance System (TCAS). Specifically, the concept addresses the determination of well clear values that are large enough to avoid issuance of TCAS corrective Resolution Advisories, undue concern by pilots of proximate aircraft and issuance of controller traffic alerts. The concept also addresses appropriate declaration times for projected losses of well clear conditions and maneuvers to regain well clear separation

Evidence for Increased Beta-Adrenoreceptor Responsiveness Induced by 14 Days of Simulated Microgravity in Humans

We studied hemodynamic responses to alpha and beta receptor agonists in 8 healthy men ( 38+- 2 yrs) before and after 14 days of 6 degree head-down tilt (HDT) to test the hypothesis that increased adrenergic responsiveness is induced by prolonged exposure to microgravity. Immediately following a 30-min baseline period, a steady-state infusion of isoproterenol (ISO) was used to assess beta 1- and beta 2-adrenergic responsiveness. ISO was infused at three graded constant rates of 0.005, 0.01 and 0.02 ug/kg/min. After heart rate and blood pressure had been allowed to return to baseline levels following ISO infusion graded infusion of phenylephrine (PE) was used to assess responsiveness of alpha I-vascular receptors. PE was infused at three graded constant rates of 0.25, 0.50 and 1.00 ug/kg/min. Each infusion interval for both drugs was 9 min. During the infusions, constant monitoring of beat-to-beat blood pressure and heart rate was performed and leg blood flow was measured with occlusion plethysmography at each infusion level. The slopes calculated from linear regressions between ISO and PE doses and changes in heart rate, blood pressure, and leg vascular resistance for each subject were used to represent alpha- and beta- adrenoreceptor responsiveness. Fourteen days HDT increased the slopes of heart rate (1056 +- 107 to 1553 +- 83 beats/ug/kg/min; P= 0.014) and vasodilation (-469ft +- 111 to -l446 +- 309 PRU/ug/kg/min; P =0.0224) to ISO infusion. There was no alteration in blood pressure or vascular resistance responses to PE infusion after HDT. Our results provide evidence that microgravity causes selective increases in beta 1- and beta 2-adrenergic responsiveness without affecting alpha 1-vascular responses

Airborne Precision Spacing for Dependent Parallel Operations Interface Study

This paper describes a usability study of proposed cockpit interfaces to support Airborne Precision Spacing (APS) operations for aircraft performing dependent parallel approaches (DPA). NASA has proposed an airborne system called Pair Dependent Speed (PDS) which uses their Airborne Spacing for Terminal Arrival Routes (ASTAR) algorithm to manage spacing intervals. Interface elements were designed to facilitate the input of APS-DPA spacing parameters to ASTAR, and to convey PDS system information to the crew deemed necessary and/or helpful to conduct the operation, including: target speed, guidance mode, target aircraft depiction, and spacing trend indication. In the study, subject pilots observed recorded simulations using the proposed interface elements in which the ownship managed assigned spacing intervals from two other arriving aircraft. Simulations were recorded using the Aircraft Simulation for Traffic Operations Research (ASTOR) platform, a medium-fidelity simulator based on a modern Boeing commercial glass cockpit. Various combinations of the interface elements were presented to subject pilots, and feedback was collected via structured questionnaires. The results of subject pilot evaluations show that the proposed design elements were acceptable, and that preferable combinations exist within this set of elements. The results also point to potential improvements to be considered for implementation in future experiments