8 research outputs found
Roles of basolateral solute uptake via NKCC1 and of myosin II in vasopressin-induced cell swelling in inner medullary collecting duct
No full textAbstract 649: Biobank collaboration enables cancer modeling with high quality biospecimens and data
No full textAccording to the National Cancer Institute, the lack of standardized, high-quality biospecimens is one of the most significant roadblocks to progress in cancer research. This shortage especially affects the generation of murine xenograft models of human cancers. Maine, with the third largest age-adjusted cancer incidence rate in the nation, has abundant cancer specimens potentially available for research. To meet the need for quality biospecimens, the biobanks at Eastern Maine Medical Center and Maine Medical Center have established a collaboration to jointly procure cancer specimens from Maine patients. Through this collaboration, the cooperating biobanks provide researchers with tissue, blood, bone marrow and other body fluid specimens from a broad spectrum of solid and hematologic cancers. The specimens from hematologic cancer patients have \u3e 90% viability and demonstrate anticipated biomarker composition by flow cytometry. The comparatively high frequency of engraftment of solid tumors in immunodeficient mice is also indicative of the quality of the samples procured by both repositories. Currently, the biobanks are providing fresh ovarian tumors to develop new xenograft models for poorly engrafting tumors in collaboration with the Jackson Laboratory\u27s Patient Derived Xenograft Program. Both biobanks are integrated with clinical and pathology practices and, therefore, the specimens are annotated with in-depth, de-identified patient datasets. With support from the Maine Cancer Foundation, the biobanks have created the Maine Cancer Biospecimen Portal (MBCP), a website that provides one-stop access to annotated cancer biospecimens and to consultation services for translational research study design. The collaboration of the EMMC and MMC biobanks provides a resource of high quality biospecimens for advancement of both in vivo and in vitro translational research such as mouse models of human cancers
Chemical analysis of sediments from the Galapagos Spreading Center (DSDP Leg 54, site 424)
No full textThe deposits from the DSDP Site 424 hole are divided into two major categories according to the relative proportions of the green clay-rich fractions and the presence of Fe-Mn concretions. The Fe-Mn concretions are associated with interlayers of pelagic foraminiferal nannofossil ooze from the Upper Pleistocene. This carbonate ooze is rather enriched in Mn by comparison with the green clay-rich fractions. Representative carbonate ooze samples have been chemically analysed by Cambon P. and Etoubleau J. from COB-CNEXO (Ifremer) using X-ray fluorescence
