80 research outputs found
TCERG1L allelic variation is associated with cisplatin-induced hearing loss in childhood cancer, a PanCareLIFE study.
In children with cancer, the heterogeneity in ototoxicity occurrence after similar treatment suggests a role for genetic susceptibility. Using a genome-wide association study (GWAS) approach, we identified a genetic variant in TCERG1L (rs893507) to be associated with hearing loss in 390 non-cranial irradiated, cisplatin-treated children with cancer. These results were replicated in two independent, similarly treated cohorts (n = 192 and 188, respectively) (combined cohort: P = 5.3 × 10-10, OR 3.11, 95% CI 2.2-4.5). Modulating TCERG1L expression in cultured human cells revealed significantly altered cellular responses to cisplatin-induced cytokine secretion and toxicity. These results contribute to insights into the genetic and pathophysiological basis of cisplatin-induced ototoxicity
East Indians in Trinidad: A Study in Minority Politics. By Yogendra K. Malik. (London, New York: Oxford University Press for The Institute of Race Relations, London, 1971. Pp. xv, 199. $9.75.)
Race and Slavery in the Western Hemisphere: Quantitative Studies. Edited by Stanley L. Engerman and Eugene D. Genovese. (Princeton: Princeton University Press, 1975. Pp. xv, 556. Index. 9.75, paper.)
Small is beautiful. Peter Lankhorst. Gemeenteraadslid, Tweede Kamerlid, fractievoorzitter PPR (1974-1994)
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