Bryophytes of Uganda : 1., BBS Tropical Bryology Group expeditions, 1996-1998 ; introduction and collecting sites

The British Bryological Society Tropical Bryology Group (TBG) undertook three expeditions to Uganda, in Jan-Feb 1996, Jan-Feb 1997 and June-Jul 1998. Collections were made from 134 sites, mainly from national parks and forest reserves in western and southern Uganda

British Bryological Society expedition to Mulanje Mountain, Malawi : 13., new and other unpublished records

Further results are provided of the 1991 British Bryological Society Expedition to Mulanje Mt., Malawi including 168 taxa of bryophyte, comprising 72 taxa of liverwort (38 new to Malawi) and 96 taxa of mosses (45 new to Malawi)

Effects of publication bias on conservation planning

Conservation planning needs reliable information on spatial patterns of biodiversity. However, existing data sets are skewed: some habitats, taxa, and locations are under-represented. Here, we map geographic publication density at the sub-national scale of individual 'provinces'. We query the Web of Science catalogues SCI and SSCI for biodiversity-related publications including country and province names (for the period 1993-2016). We combine these data with other provincial-scale factors hypothesised to affect research (i.e. economic development, human presence, infrastructure and remoteness). We show that sites that appear to be understudied, compared with the biodiversity expected from their bioclimatic conditions, are likely to have been inaccessible to researchers for a diversity of reasons amongst which current or recent armed conflicts are notable. Finally, we create a priority list of provinces where geographic publication bias is of most concern, and discuss how our provincial-scale model can assist in adjusting for publication biases in conservation planning.Comment: 10 pages; 3 figures; 1 table;R code on https://github.com/raffael-hickisch; data at https://zenodo.org/record/998889; interactive at http://bit.ly/publication_density_ma

Bryophytes of Uganda : 2., new and interesting records

51 hepatics and 46 mosses are reported new to Uganda, including one moss new to Africa, one hepatic and two mosses new to mainland Africa, and 2 hepatics that are otherwise known only from their type collection

Small Molecules in Development for the Treatment of Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease resulting from pathologically low levels of survival motor neuron (SMN) protein. The majority of mRNA from the SMN2 allele undergoes alternative splicing and excludes critical codons, causing an SMN protein deficiency. While there is currently no FDA-approved treatment for SMA, early therapeutic efforts have focused on testing repurposed drugs such as phenylbutyrate (2), valproic acid (3), riluzole (6), hydroxyurea (7), and albuterol (9), none of which has demonstrated clinical effectiveness. More recently, clinical trials have focused on novel small-molecule compounds identified from high-throughput screening and medicinal chemistry optimization such as olesoxime (11), CK-2127107, RG7800, LMI070, and RG3039 (17). In this paper, we review both repurposed drugs and small-molecule compounds discovered following medicinal chemistry optimization for the potential treatment of SMA

Maize Provisioning of Ontario Late Woodland Turkeys: Isotopic Evidence of Seasonal, Cultural, Spatial and Temporal Variation

The isotopic composition (δ13C, δ15N) of bone collagen from Ontario Late Woodland archaeological turkeys was compared with that of modern Ontario wild turkeys, and archaeological turkeys from American Southwestern, Mexican and other Woodland sites to determine whether Late Woodland Ontario peoples managed wild turkeys by provisioning them with maize, the only isotopically distinct horticultural plant at that time. Despite the fact that humans from Late Woodland Western Basin and Iroquoian traditions consumed equal amounts of maize, wild turkeys utilized by the two groups exhibit different diets. Western Basin turkeys reflect a C3-only diet, whereas Iroquoian turkeys were consuming significant quantities of maize (a C4 plant). Both groups of archaeological turkey consumed less maize than modern wild turkeys with access to waste left in fields by mechanized agriculture, but because ancient crop yields were much lower, we suggest that Iroquoian turkeys must have been provisioned, probably to create a reliable and nearby hunting niche (Linares 1976). Archaeological and isotopic evidence supports ethnohistoric accounts that turkeys were hunted after the fall harvest. Iroquoian archaeological turkey diets, in general, reflect the seasonal consumption of maize that would have been created by cold weather maize provisioning, with the major exception of one turkey from an Attawandaron (Neutral) site that appears to have been fed maize year round. Motivations for provisioning by Middle Ontario Iroquoian people likely included climate change and ritual/ceremonial activity as well as a reliable food supply. Because Iroquoian women controlled the harvest, it is likely that they were instrumental in altering this human/animal interaction, creating a position on the wild/domesticated continuum that is unique in the North American archaeological literature

Transformation and representation in similarity.

Similarity, being a psychological notion, involves the comparison of finite object representations. The specific nature and complexity of these representations is a matter of fierce theoretical debate traditionally, similarity research was dominated by the spatial and featural account. In the spatial account, similarity is determined by the distance between objects in a psychological space. Alternatively, the featural account proposes that similarity is determined by matching objects' features. Despite the empirical success of these accounts, the object representations they posit are regarded too simple and specific to deal with more complex objects. Therefore, two structural accounts have been developed: structural alignment (SA) and Representational Distortion (RD). This aim of this thesis was to further establish one particular structural account RD as a general framework for understanding the similarity between object representations. Specifically, RD measures similarity by the complexity of the transformation that "distorts" one representation into the other. This RD approach is investigated in detail by testing a detailed set of transformational predictions (coding scheme) within a rich stimulus domain. These predictions are tested through experiments and modelling that utilise both a) explicit measures (ratings, forced-choice), and, for the first time, b) implicit measures (reaction time, same-different errors & spontaneous categorisation). Moreover, RD is compared empirically with both traditional and alignment models of similarity. Overall, the results suggest that similarity can be best understood by transformational relationships in a number of contexts. The performance of RD in both explicit and implicit measures is made more compelling by the fact that rival accounts fundamentally struggle to describe the sorts of relationships that are easily captured by RD. Finally, it is emphasised that RD is actually compatible with supposedly rival approaches and can incorporate theoretically these accounts, both traditional and structural, under one general framework

Evidencing a place for the hippocampus within the core scene processing network

Functional neuroimaging studies have identified several “core” brain regions that are preferentially activated by scene stimuli, namely posterior parahippocampal gyrus (PHG), retrosplenial cortex (RSC), and transverse occipital sulcus (TOS). The hippocampus (HC), too, is thought to play a key role in scene processing, although no study has yet investigated scene-sensitivity in the HC relative to these other “core” regions. Here, we characterised the frequency and consistency of individual scene-preferential responses within these regions by analysing a large dataset (n = 51) in which participants performed a one-back working memory task for scenes, objects, and scrambled objects. An unbiased approach was adopted by applying independently-defined anatomical ROIs to individual-level functional data across different voxel-wise thresholds and spatial filters. It was found that the majority of subjects had preferential scene clusters in PHG (max = 100% of participants), RSC (max = 76%), and TOS (max = 94%). A comparable number of individuals also possessed significant scene-related clusters within their individually defined HC ROIs (max = 88%), evidencing a HC contribution to scene processing. While probabilistic overlap maps of individual clusters showed that overlap “peaks” were close to those identified in group-level analyses (particularly for TOS and HC), inter-individual consistency varied across regions and statistical thresholds. The inter-regional and inter-individual variability revealed by these analyses has implications for how scene-sensitive cortex is localised and interrogated in functional neuroimaging studies, particularly in medial temporal lobe regions, such as the H