Mirror Matter as Self Interacting Dark Matter

It has been argued that the observed core density profile of galaxies is inconsistent with having a dark matter particle that is collisionless and alternative dark matter candidates which are self interacting may explain observations better. One new class of self interacting dark matter that has been proposed in the context mirror universe models of particle physics is the mirror hydrogen atom whose stability is guaranteed by the conservation of mirror baryon number. We show that the effective transport cross section for mirror hydrogen atoms, has the right order of magnitude for solving the ``cuspy'' halo problem. Furthermore, the suppression of dissipation effects for mirror atoms due to higher mirror mass scale prevents the mirror halo matter from collapsing into a disk strengthening the argument for mirror matter as galactic dark matter.Comment: 6 pages; some references adde

Geophysical constraints on mirror matter within the Earth

We have performed a detailed investigation of geophysical constraints on the possible admixture of mirror matter inside the Earth. On the basis of the Preliminary Reference Earth Model (PREM) -- the `Standard Model' of the Earth's interior -- we have developed a method which allows one to compute changes in various quantities characterising the Earth (mass, moment of inertia, normal mode frequencies etc.)due to the presence of mirror matter. As a result we have been able to obtain for the first time the direct upper bounds on the possible concentration of the mirror matter in the Earth. In terms of the ratio of the mirror mass to the Earth mass a conservative upper bound is $3.8\times 10^{-3}$. We then analysed possible mechanisms (such as lunar and solar tidal forces, meteorite impacts and earthquakes) of exciting mirror matter oscillations around the Earth centre. Such oscillations could manifest themselves through global variations of the gravitational acceleration at the Earth's surface. We conclude that such variations are too small to be observed. Our results are valid for other types of hypothetical matter coupled to ordinary matter by gravitation only (e.g. the shadow matter of superstring theories).Comment: 25 pages, in RevTeX, to appear in Phys.Rev.

Explaining ΩBaryon≈0.2ΩDark\Omega_{Baryon} \approx 0.2 \Omega_{Dark} through the synthesis of ordinary matter from mirror matter: a more general analysis

The emerging cosmological picture is of a spatially flat universe composed predominantly of three components: ordinary baryons ($\Omega_B \approx 0.05$), non-baryonic dark matter ($\Omega_{Dark} \approx 0.22$) and dark energy ($\Omega_{\Lambda} \approx 0.7$). We recently proposed that ordinary matter was synthesised from mirror matter, motivated by the argument that the observed similarity of $\Omega_B$ and $\Omega_{Dark}$ suggests an underlying similarity between the fundamental properties of ordinary and dark matter particles. In this paper we generalise the previous analysis by considering a wider class of effective operators that non-gravitationally couple the ordinary and mirror sectors. We find that while all considered operators imply $\Omega_{Dark} =$ few$\times \Omega_B$, only a subset quantitatively reproduce the observed ratio $\Omega_B/\Omega_{Dark} \approx 0.20$. The $\sim 1$ eV mass scale induced through these operators hints at a connection with neutrino oscillation physics.Comment: minor changes, some references added, about 10 page

More about neutron - mirror neutron oscillation

It was pointed out recently that oscillation of the neutron $n$ into mirror neutron $n'$, a sterile twin of the neutron with exactly the same mass, could be a very fast process with the the baryon number violation, even faster than the neutron decay itself. This process is sensitive to the magnetic fields and it could be observed by comparing the neutron lose rates in the UCN storage chambers for different magnetic backgrounds. We calculate the probability of $n-n'$ oscillation in the case when a mirror magnetic field $\vec{B}'$ is non-zero and show that in this case it can be suppressed or resonantly enhanced by applying the ordinary magnetic field $\vec{B}$, depending on its strength and on its orientation with respect to $\vec{B}'$. The recent experimental data, under this hypothesis, still allow the $n-n'$ oscillation time order 1 s or even smaller. Moreover, they indicate that the neutron losses are sensitive to the orientation of the magnetic field. %at about $3\sigma$ level. If these hints will be confirmed in the future experiments, this would point to the presence of the mirror magnetic field on the Earth of the order of 0.1 G, or some equivalent spin-dependent force of the other origin that makes a difference between the neutron and mirror neutron states.Comment: 10 page

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Declarative memory impairments in Alzheimer's disease and semantic dementia

Semantic dementia (SD) and Alzheimer's disease (AD) are both disorders in which early pathology affects the temporal lobe Net they produce distinct syndromes of declarative memory impairment-loss of established semantic knowledge with relatively preserved episodic memory in the former and the converse in the latter. Groups with mild SD and mild AD who showed a double dissociation in these two aspects of declarative memory were studied-the SD group's episodic memory and the AD group's semantic knowledge each being comparable to controls. Positron emission tomography and volumetric magnetic resonance imaging were used to map deficits in regional cerebral metabolic rate and mesial temporal lobe MTL atrophy, respectively. Episodic memory impairment in AD was associated with dysfunction of an integrated network (mesial temporal lobe, mamillary bodies, dorsomesial thalamus and posterior cingulate). Semantic memory impairment in SD was associated with bilateral rostra] temporal lobe hypometabolism. The SD group had comparable MTL atrophy and hypometabolism to that found in AD but the remainder of their limbic-diencephalic network was preserved suggesting that the latter explains their ability to acquire new episodic memories. The results challenge the view that amnesia in early AD can be explained by the degree of MTL damage alone while showing that semantic impairment can occur with damage restricted to the rostral temporal lobes. (c) 2005 Elsevier Inc. All rights reserved

Limbic hypometabolism in Alzheimer's disease and mild cognitive impairment

The neural basis of the amnesia characterizing early Alzheimer's disease (AD) remains uncertain. Postmortem pathological studies have suggested early involvement of the mesial temporal lobe, whereas in vivo metabolic studies have shown hypometabolism of the posterior cingulate cortex. Using a technique that combined the anatomic precision of magnetic resonance imaging with positron emission tomography, we found severe reductions of metabolism throughout a network of limbic structures (the hippocampal complex, medial thalamus, mamillary bodies, and posterior cingulate) in patients with mild AD. We then studied a cohort with mild cognitive impairment in whom amnesia was the only cognitive abnormality and found comparable hypometabolism through the same network. The AD and mild cognitive impairment groups were differentiated, however, by changes outside this network, the former showing significant hypometabolism in amygdala and temporoparietal and frontal association cortex, whereas the latter did not. The amnesia of very early AD reflects severe but localized limbic dysfunction

Behavioural variant frontotemporal dementia: not all it seems?

Background: the diagnosis of the behavioural variant of frontotemporal dementia (bvFTD) can be challenging. At present there is a paucity of prospective work addressing the specificity of current diagnostic criteria for bvFTD with respect to long-term outcome (i.e., false positives versus true positives).Methods: here we report two individuals who met current clinical criteria for bvFTD and who underwent detailed long-term clinical and neuropsychological follow-up. In addition, both had serial volumetric MRI and functional metabolic (FDG-PET) imaging separated by 5 years.Results: one case had a slow clinical decline as well as both progressive atrophy and hypometabolism in a frontotemporal distribution, consistent with a neurodegenerative FTD syndrome. However, the second developed neither atrophy nor hypometabolism and remained clinically stable, a decade from symptom onset.Conclusion: we propose that these cases illustrate that while there may be a slow evolution in bvFTD, it is possible that some cases who meet current criteria may not have a neurodegenerative syndrome. If correct, this hypothesis has important implications for the current diagnostic criteria. A potential hierarchy for diagnostic certainty in bvFTD is suggested