Evaluation of the dose distribution behind the prostheses in prostate cancer patients with hip prostheses using film dosimetry and specially designed phantom [Kalça protezli prostat kanseri hastalari{dotless} için protez arkasi{dotless}ndaki doz dagi{dotless}li{dotless}mi{dotless}ni{dotless}n film dozimetre ve özel olarak tasarlanmi{dotless}ş fantom kullani{dotless}larak degerlendirilmesi]

OBJECTIVES: We aimed to investigate the effect of hip prostheses on dose distribution in radiotherapy patients. METHODS: Solid Water phantom-containing prostheses (cobalt-chromium-molybdenum and cobalt-chromium-molybdenum-titanium) were placed between the phantoms used for the measurements. Films at 10, 20 and 30 cm depths were irradiated for 6 and 18 MV with 50 cGy dose in the presence or not of prosthesis. Dose profiles were evaluated statistically. RESULTS: For 6 and 18 MV photon energies, significant differences was found along the thick and vertical axes of both prostheses at 10 and 20 cm depths and along the middle, thick and vertical axis at 30 cm depth (p<0.05). CONCLUSION: Hip prostheses affect radiotherapy dose distribution, and this should be considered when planning a treatment. © 2012 Association of Oncology

The Effect of Resveratrol and Quercetin on Epithelial-Mesenchymal Transition in Pancreatic Cancer Stem Cell

Resveratrol and quercetin are phytochemicals that are found in a variety of plants. The aim of this study was to investigate the effect of resveratrol and quercetin on epithelial-mesenchymal transition (EMT) of CD133+ and CD133− pancreatic cancer cells. Cancer stem cells (CD133+ cells) were obtained from the PANC-1 cells by the MiniMACS system. CD133+ and CD133− PANC-1 cells were treated with different concentrations (5, 10, 25, 50, and 100 µM) of resveratrol and quercetin. Cell growth and cytotoxicity were evaluated by MTT assay. Anticancer and anti-metastatic properties of resveratrol and quercetin were determined by immunocytochemistry using antibodies (ACTA-2, IL-1β, N-cadherin, TNF-α, and vimentin). The immunostaining intensity of CD133+ cells was stronger than CD133− cells. ACTA-2, IL-1β, and N-cadherin immunoreactivities were significantly decreased, whereas TNF-α and vimentin immunoreactivities significantly increased in quercetin-treated CD133+ cells. Moreover, N-cadherin and TNF-α immunoreactivities significantly decreased in resveratrol-treated CD133+ cells. The reduction in N-cadherin and ACTA-2 immunoreactivities was higher than the increase in vimentin immunoreactivity, quercetin could prevent EMT to a greater extent than resveratrol in pancreatic cancer stem cells because of the reduced expression of N-cadherin. Quercetin could be more effective in inhibiting metastasis compared to resveratrol. © 2019, © 2019 Taylor & Francis Group, LLC

Evaluation of the Charlson Comorbidity Index and Laboratory Parameters as Independent Early Mortality Predictors in Covid 19 Patients

Betül Cavu&scedil;o&gbreve;lu Türker,1 Fatih Türker,2 Süleyman Ahbab,2 Emre Hoca,2 Ay&scedil;e Oznur Urvas&inodot;zo&gbreve;lu,2 Seher Irem Cetin,2 Hayriye Esra Atao&gbreve;lu2 1University of Health Sciences, Taksim Health Training and Research Hospital, Internal Medicine Clinic, &Idot;stanbul, Turkey; 2University of Health Sciences, Haseki Health Training and Research Hospital, Internal Medicine Clinic, &Idot;stanbul, TurkeyCorrespondence: Fatih Türker, University of Health Sciences, Haseki Health Training and Research Hospital, Internal Medicine Clinic, Aksaray, Dr. Adnan Ad&inodot;var Cd. No: 9, Fatih, &Idot;stanbul, 34130, Turkey, Tel +905364721656, Fax +90 212 453 20 00, Email [email protected]: Purpose: Various parameters have been proposed to predict the outcome of patients with coronavirus disease. The aim of this study was to evaluate the utility of the age-adjusted CCI score and biochemical parameters for predicting outcomes for COVID-19 patients on admission.Patients and methods: A total of 511 patients were included in the study. Only swab or serological tests positive patients were included. The clinical characteristics of the patients were compared between survival and non-survival COVID-19 inpatients. Hemoglobin, platelet, sedimentation, creatinine, AST, ALT, LDH, CK, albumin, ferritin, lymphocyte, neutrophil, CRP (1– 5;5– 10;10– 20 × upper limit), procalcitonin (5– 10;10– 20; > 20 × upper limit), D Dimer (> 2 × upper limit), age, gender, chronic diseases and CCI scores were compared between the two groups.Results: 68 patients died and 443 patients survived. Mean age was 74.3± 7.3 years in survival group and 76.7± 8.0 in nonsurvival group. Age, male sex, ischemic heart disease (CHD), chronic kidney disease and active malignancy was statistically higher in non-survivor group. The biochemical parameters was compared in survival and nonsurvival group. CCI score, AST, LDH, CK, Ferritin, CRP are significantly higher and albumin, lymphocyte levels are significantly lower in nonsurvival group. D-dimer and procalcitonin levels are significantly higher in nonsurvival group. CCI score and neutrophil, creatinine, ALT, AST, d-dimer and procalcitonin elevations were correlated. Low albumin and lymphocyte levels were correlated with the CCI score. There was no significant correlation between ferritin, sedimentation, CRP levels and CCI score. A multivariate logistic regression analysis indicated that anaemia, elevated CRP (> 10– 20 × upper limit), procalcitonin (> 5– 10 × upper limit), ALT, AST levels and higher CCI score were independent risk factors for mortality in COVID-19 patients.Conclusion: Anaemia, elevated CRP, procalcitonin levels, ALT, AST levels and higher CCI score were found independent risk factors for mortality in COVID-19 patients.Keywords: CCI score, laboratory parameters, mortality, COVID 1

Superparamagnetic Iron Oxide Nanoparticle Mediated Radiosensitization at Megavoltage Radiation

38th Annual Meeting of the European-Society-for-Radiotherapy-and-Oncology (ESTRO) -- APR 26-30, 2019 -- Milan, ITALYWOS: 000468315603041European Soc Radiotherapy & Onco

Superparamagnetic Iron Oxide Nanoparticle Mediated Radiosensitization at Megavoltage Radiation

38th Annual Meeting of the European-Society-for-Radiotherapy-and-Oncology (ESTRO) -- APR 26-30, 2019 -- Milan, ITALYWOS: 000468315603041European Soc Radiotherapy & Onco

A Critical Review of Public Borrowing by Turkish Municipalities: 1960-2006

This paper offers an analysis of municipal borrowing in Turkey during 1960-2006 in two sub-periods: 1960-79 and 1980-2006. These sub-periods are distinguished from each other as different regimes of capital accumulation, taking 1980 as the breaking point. In this framework, the capital accumulation model of the import substitution era of 1960-79 is assessed in the context of the national developmental state, while the financial capital accumulation regime in the post-1980 period is studied in the context of financial globalisation. The impacts of these two regimes on the debt structures of municipalities are compared using period-specific indices of indebtedness. It is found that indebtedness in real terms increased significantly in the post-1980 sub-period, which can be attributed to the adoption of the financial capital accumulation regime.