Can the ADO Index Be Used as a Predictor of Mortality from COVID-19 in Patients with COPD?

Esra Ertan Yazar,1 Gulsah Gunluoglu,2 Burcu Arpinar Yigitbas,1 Mukadder Calikoglu,3 Gazi Gulbas,4 Nilgün Y&inodot;lmaz Demirci,5 Nurhan Sarioglu,6 Fulsen Bozkus,7 Nevin Taci Hoca,5 Nalan Ogan,8 Seda Tural Onur,2 Muzaffer Onur Turan,9 Filiz Kosar,2 Evrim Eylem Akpinar,8 Burak Mete,10 Can Ozturk5 1Department of Chest Diseases, Istanbul Medeniyet University, Medical Faculty, Istanbul, Turkey; 2Department of Chest Diseases, Yedikule Chest Disease and Chest Surgery Research and Training Hospital, Istanbul, Turkey; 3Department of Chest Diseases, Mersin University, Medical Faculty, Mersin, Turkey; 4Department of Chest Diseases, Inonu University, Medical Faculty, Malatya, Turkey; 5Department of Chest Diseases, Gazi University, Medical Faculty, Ankara, Turkey; 6Department of Chest Diseases, Balikesir University, Medical Faculty, Balikesir, Turkey; 7Department of Chest Diseases, Kahramanmaras Sutcu Imam University, Medical Faculty, Kahramanmaras, Turkey; 8Department of Chest Diseases, Ufuk University, Medical Faculty, Ankara, Turkey; 9Department of Chest Diseases, Prof Dr, Izmir Katip Celebi University, Atatürk Research and Training Hospital, Izmir, Turkey; 10Department of Public Health Çukurova University, Medical Faculty, Adana, TurkeyCorrespondence: Esra Ertan Yazar, Istanbul Medeniyet University, Medical Faculty, Department of Chest Diseases, Istanbul, Turkey, Email [email protected]: Several studies have shown that the risk of mortality due to COVID-19 is high in patients with COPD. However, evidence on factors predicting mortality is limited.Research Question: Are there any useful markers to predict mortality in COVID-19 patients with COPD?.Study Design and Methods: A total of 689 patients were included in this study from the COPET study, a national multicenter observational study investigating COPD phenotypes consisting of patients who were followed up with a spirometry-confirmed COPD diagnosis. Patients were also retrospectively examined in terms of COVID-19 and their outcomes.Results: Among the study patients, 105 were diagnosed with PCR-positive COVID-19, and 19 of them died. Body mass index (p= 0.01) and ADO (age, dyspnoea, airflow obstruction) index (p= 0.01) were higher, whereas predicted FEV1 (p< 0.001) and eosinophil count (p= 0.003) were lower in patients who died of COVID-19. Each 0.755 unit increase in the ADO index increased the risk of death by 2.12 times, and each 0.007 unit increase in the eosinophil count decreased the risk of death by 1.007 times. The optimum cut-off ADO score of 3.5 was diagnostic with 94% sensitivity and 40% specificity in predicting mortality.Interpretation: Our study suggested that the ADO index recorded in the stable period in patients with COPD makes a modest contribution to the prediction of mortality due to COVID-19. Further studies are needed to validate the use of the ADO index in estimating mortality in both COVID-19 and other viral respiratory infections in patients with COPD.Keywords: body mass index, COVID-19, eosinophils, FEV1, mortality, pneumonia, pulmonary disease, chronic obstructiv

Purification and characterization of prickly pear (Opuntia ficus-indica) alpha-galactosidase by three-phase partitioning

38th Congress of the Federation-of-European-Biochemical-Societies (FEBS) -- JUL 06-11, 2013 -- Saint Petersburg, RUSSIAWOS: 000325919203457Federat European Biochemical So

Irradiation of Subventricular Zone in Glioblastoma: Its Impact on Tumor Progression and Survival

WOS: 00046778630125

Lateral ventricule invasion and radiation dose to subventricular zone: Their impact to the treatment outcomes of glioblastoma

WOS: 000458419600002Background: This study was conducted to evaluate the recurrence patterns of GBM in regard to its contact with LVs, the relation between radiation doses to subventrivular zone (SVZ). Materials and Methods: Between 2012 and 2014, 80 adult patients with GBM were included this trial. Median follow-up period was 15 months. Median tumor size was 4.5 cm (1.3-8 cm), where 58% of the patients had a tumor larger than 4 cm. All of the lesions were located supratentorial part of brain. Tumors were classified based on whether the mass involved the SVZ and/or LVs. Reccurrence patterns and treatment outcomes were compared. Results: Tumor progression occurred in 60 (75%) of the patients. Of those 31 (51.6%) were in-field. Median progression-free survival (PFS) and median overall survival (OS) times were 11 and 15 months, respectively. On multivariate analysis, the negative prognostic factors were maximal surgical resection (p=0.027), LV-invading tumor (p=0.001) and p53 positivity (p=0.034) for PFS. It was found that the patients receiving >50 Gy to iSVZ dose (p=0.024) or >40 Gy to cSVZ dose (p=0.002) or >40 Gy to bSVZ dose (p=0.028) or >50 Gy to bSVZ dose (p=0.008) tended to have more recurrences. Both in-field and out-field recurrences were not affected by higher radiation doses. Conclusion: LVs invading and/or location close to the SVZs can be considered as an important prognostic factor in terms of decreased PFS and OS rates. Additionally both SVZs sparing and dose escalation to SVZs approaches are required to be evaluated in further researches

The Effect of Short-Term Drying on Biofilm Formed in a Model Water Distribution System

In this study the effect of short-term drying on biofilm-related bacteria was investigated. Biofilm formation was encouraged to develop for nine months in a model water-distribution system. Biofilms were analyzed monthly for enumeration of aerobic and anaerobic heterotrophic bacteria, and sulphate reducing bacteria (SRB) after 6, 24, 48, and 72 hours of exposure to drying. The numbers of live and dead bacteria were directly analyzed by epifluorescence microscopy. In addition, extracellular polysaccharide substances (EPS) extraction, carbohydrate analysis, and scanning electron microscope (SEM) observation were performed. The formation of a brown-colored, thin biofilm layer was observed on the inner surface of polypropylene pipes at the end of the experimental study. SEM micrographs showed that ruptures occurred in the biofilm layer due to effects of drying. The counts of aerobic heterotrophic bacteria and SRB in dried biofilm samples decreased significantly after 6 and 48 hours, respectively. According to 5-cyano-2,3-ditolyl-tetrazolium chloride (CTC) staining results, bacteria can remain viable for up to 72 hours after exposure to drying. The significant increase in the amount of carbohydrate after 48 hours of exposure to drying indicates that bacteria produce EPS as a protective mechanism against drying stress

Repositining of prostate cancer patients, using implanted gold seeds into prostate and electronic portal imaging device [Prostat bezine implant edilmiş alti{dotless}n çekirdekleri ve elektronik portal görüntüleme cihazi{dotless} kullanarak prostat kanseri hastalari{dotless}ni{dotless}n yeniden pozisyonlandi{dotless}ri{dotless}lmasi{dotless}]

OBJECTIVES To investigate the feasibility of target focused treatment and it's advantages on standard treatment position verifying tecniques using gold markers and electronic portal imaging device (EPID). METHODS Marker placed 10 patient's films were taken, transferred to planning system and distance between markers was measured. Port images were taken by EPID and Template Matching option was used for matching ports with digitally reconstructed radiograph. The distance between markers and the changes were determined with analytic process. Systematical and random set-up errors were determined. RESULTS No important changes on marker positions and no radiation toxicity was observed. Verifying the treatment positions according to markers in terms of position correction gain was better compared to verifying according to bone anatomy (p<0.05). Target focused position verifying was the best way for reducing both systematical and random set-up errors. CONCLUSION The decrease in standard deviation of systematical and random errors provides statistically meaningful decrease in minimum PTV margins. © 2013 Association of Oncology

Retrospective clinical and radiologic analysis of adult high-grade glioma recurrence after temozolomide-based radiochemotherapy [Yetişkin yüksek dereceli gliom olgularinin radyokemoterapi sonrasi yinelemelerinin klinik ve radyolojik değerlendirilmesi]

Background: The aim of this study was to evaluate the recurrence patterns and the times of recurrence after temozolomide-based radiochemotherapy for high grade gliomas. Methods: Magnetic resonance imaging (MRI), diffusion MRI, perfusion MRI, and MRI spectroscopy scans of 30 patients who were treated with radiotherapy concurrently with temozolomide chemotherapy between June 2009 and April 2012 were retrospectively evaluated. Central, in-field, marginal, and distant recurrences of progression were defined related to radiation therapy dose distribution (90% isodose line). Results: The overall survival (OS) rates of central recurrences at 1 year and 2 years were 78% and 25%, respectively (at a median of 16 months). The OS rate of in-field, marginal and distant recurrences at 1 year and 2 years were 100% and 40%, respectively (at a median of 24 months). The progression-free survival (PFS) rate of central recurrences at 1 year and 2 years were 21% and 0%, respectively (at a median of 5 months). The PFS rate of in-field, marginal and distant recurrences at 1 year and 2 years were 36% and 27%, respectively (at a median of 11 months). The PFS rate of pseudoprogression at 1 year and 2 years were 87% and 43% (range, 7-31 months). Conclusions: The survival of new in-field, marginal and distant recurrences are longer and these new lesions develop at a later time compared with central recurrences. Pseudoprogression predicts better response to temozolomide-based radiochemotherapy. Finally, the location of recurrence is determined as one of the prognostic factors for OS and PFS. © 2018, Ege University Press. All rights reserved