19 research outputs found
Priming Effects of Triethylene Glycol and Triethylene Glycol Monomethacrylate on Dentin Bonding
Technical variation of trans-articular sacroiliac joint (SIJ) fusion using three screws considering the effects of sacral dysplasia in patients with non-traumatic SIJ pain
Combined exposure to carbon disulfide and sulfuric acid simultaneously increases the risk of hand dermatitis in rayon industry
Polycaprolactone membranes reinforced by toughened sol-gel produced silica networks
The aim of this work is to develop polycaprolactone based porous materials with improved mechanical performance to be used in bone repair. The hybrid membranes consist in a polymeric porous material in which the pore walls are coated by a silica thin layer. Silica coating increases membrane stiffness with respect to pure polymer but in addition filling the pores of the polymer with a silica phase improves bioactivity due to the delivery of silica ions in the neighborhood of the material in vivo. Nevertheless silica network, even that produced by sol–gel, might be too stiff and brittle what is not desirable for its performance as a coating. In this work we produced a toughened silica coating adding chitosan and 3-glycidoxypropyltrimethoxysilane (GPTMS) to the precursor solution looking for having polymer chains linked by covalent bonding to the silica network. Hybrid polymer–silica coating was produced by in situ sol–gel reaction using Tetraethyl orthosilicate (TEOS), GPTMS and chitosan. Chemical reaction between amine groups of chitosan chains and epoxy groups of GPTMS allowed covalent bonding of polymer chains to the silica network. Physical properties of the hybrid membranes were characterized and cell attachment of MC3T3-E1 pre-osteoblastic cells on the surface of these supports was assessed.Fundação para a Ciência e a Tecnologia (FCT)CEPB acknowledges the economic support of
COOPEN agreement in the progress of the present work. JFM
acknowledges the support from Fundac¸a˜o para a Cieˆncia e Tecnologia
through project PTDC/FIS/115048/2009. JLGR acknowledges the
support of the Spanish Ministry of Education through project No.
MAT2010-21611-C03-01. CIBER-BBN is an initiative funded by the
VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider
Program, CIBER Actions and financed by the Instituto de
Salud Carlos III with assistance from the European Regional Development
Fund. Authors want to thank the technical support of the
Universitat Polite`cnica de Vale`ncia’s Microscopy Service