925 research outputs found
Anomalous Coexistence of Ferroelectric Phases ( and ) in Orthorhombic EuYMnO () Crystals
We have investigated the magnetic and dielectric properties of orthorhombic
EuYMnO () single crystals without the presence
of the 4 magnetic moments of the rare-earth ions. In , the
magnetic-structure driven ferroelectricity is observed. The ferroelectric
transition temperature is steeply reducing with increasing . In , two ferroelectric phases ( and ) are
coexistent at low temperatures. In these phases, ferroelectricity has different
origin, which is evidenced by the distinctive poling-electric-field dependence
of electric polarization. Namely, the electric polarization along the c axis
() is easily saturated by a poling electric field, therefore is
caused by the spiral antiferromagnetic order. On the other hand, the
electric polarization along the a axis () is probably attributed to the
collinear -type antiferromagnetic order, because is unsaturated even
in a poling field of V/m.Comment: 10 pages, 4figures, to be published in Journal of the Physical
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Photoactivatable genetically encoded calcium indicators for targeted neuronal imaging.
Circuit mapping requires knowledge of both structural and functional connectivity between cells. Although optical tools have been made to assess either the morphology and projections of neurons or their activity and functional connections, few probes integrate this information. We have generated a family of photoactivatable genetically encoded Ca(2+) indicators that combines attributes of high-contrast photolabeling with high-sensitivity Ca(2+) detection in a single-color protein sensor. We demonstrated in cultured neurons and in fruit fly and zebrafish larvae how single cells could be selected out of dense populations for visualization of morphology and high signal-to-noise measurements of activity, synaptic transmission and connectivity. Our design strategy is transferrable to other sensors based on circularly permutated GFP (cpGFP)
Cranial and intra-axial metastasis originating from a primary ovarian Dysgerminoma.
Dysgerminomas are aggressive germ cell tumors that typically have a favorable prognosis, especially in patients diagnosed with early stage disease. We recount the history of a 23-year-old woman who was treated for a stage IA ovarian dysgerminoma in November 2017. Postoperatively, the patient was noncompliant insofar as obtaining routine lab evaluations; ten months later, she was diagnosed with a cranial metastasis that extended into the meninges. The patient subsequently underwent a posterior fossa craniotomy and adjuvant etoposide, bleomycin and cisplatin chemotherapy to which she initially responded; however, during cycle 4, she developed pancytopenia whereupon the chemotherapy was summarily discontinued. Thereafter, the patient was surveilled and currently, she remains in clinical remission. Early stage ovarian dysgerminoma, albeit rarely, has the capacity to metastasize to the cranium or brain, further underscoring the significance of employing active follow-up with these patients
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