PCR-based genotyping and susceptibility of acute otitis media isolates.

<p>gPSSP, genetically penicillin susceptible <i>S. pneumoniae</i>; gPISP, genetically penicillin intermediate <i>S. pneumoniae</i>; gPRSP, genetically penicillin resistant <i>S. pneumoniae</i>;</p><p>MLS_B, Macrolide-lincosamide-streptogramin B.</p><p><i>S. pneumoniae.</i></p

Incidence and severity of AOM by age, and vaccination coverage during 2 years surveillance.

*<p>Average of January 2010 and January 2011 in Sado Island.</p>**<p>Vaccination coverage in Sado Island on November 2011.</p><p>AOM, acute otitis media; PCV7, 7-valent pneumococcal conjugate vaccine; Hib, <i>H. influenzae</i> type b; N.A., not available.</p

Proportion of serotypes and resistance genes in acute otitis media patients 2A. <i>S. pneumoniae.</i>

<p>Serotype coverage of 7- and 13-valent pneumococcal conjugate vaccine in this study were 38.0% (95% CI: 29.3–47.3) and 62.8% (95% CI: 53.6–71.4%), respectively. 2B. <i>H. influenzae.</i> Of 122<i> H. influenzae</i> available for typing, 120 were NTHi and 2 were Hib. Resistance genotyping showed that 9% were gBLPACR-III, 43% were gBLNAR-III, 4% were gBLNAR-I/II, 40% were gBLNAS, and 4% were nontypeable. gPSSP, genetically penicillin susceptible <i>S. pneumoniae</i>; gPISP, genetically penicillin intermediate <i>S. pneumoniae</i>; gPRSP, genetically penicillin resistant <i>S. pneumoniae</i>; gBLNAS, genetically beta-lactamase-negative ampicillin-susceptible isolates; gBLNAR, genetically beta-lactamase-negative ampicillin-resistant isolates; gBLPACR, genetically beta-lactamase-positive ampicillin-resistant isolates; NTHi, nontypeable <i>H. influenzae.</i></p

Pediatric patients with acute otitis media in Sado Island by surveillance week 1A.

<p>The proportion of acute otitis media patients with 95% CI among all outpatients showing acute illness. 1B. The black bar and gray bar indicate the number of acute otitis media patients and all outpatients with acute illness, respectively. AOM, acute otitis media.</p

Severity and bacterial pathogens in acute otitis media.

a<p>at least 1 of these pathogens was isolated.</p>b<p>at least 2 of these pathogens were isolated.</p>c<p>Comparing with mild, moderate, and severe groups.</p><p>N.A., not analyzed.</p