The effect of pCO2 on size-fractionated phytoplankton community in the Southern Ocean

第3回極域科学シンポジウム　横断セッション「南極海季節的海氷域における生物地球化学」11月26日（月） 統計数理研究所 セミナー

Hepatic Arterial Infusion Chemotherapy Prior to Standard Systemic Chemotherapy in Patients with Highly Advanced Unresectable Liver Metastases from Colorectal Cancer: A Report of Three Patients

We administered hepatic arterial infusion chemotherapy (HAIC) prior to FOLFOX to three patients with unresectable liver metastases from colorectal cancer. The patients' disease state was found to be highly advanced based on both computed tomography findings and liver function tests. The treatment strategy included an initial administration of HAIC to control liver metastases and improve liver function in order to facilitate the subsequent safe administration of FOLFOX without drug loss. As the HAIC regimen, 1,000mg/m2 of 5-FU was administered weekly by continuous 5-h infusion after performing laboratory investigations through an implanted port-catheter system. After 3 HAIC cycles administered over 3 consecutive weeks, the mean alkaline phosphatase levels decreased from 969.3IU/l to 422IU/l due to shrinkage of the liver metastases. Thereafter, FOLFOX without drug loss could be safely initiated for all patients. Two patients succumbed 488 and 333 days after HAIC was initiated;the third patient is still alive and has been followed-up for 1215 days. The combined use of HAIC and standard systemic chemotherapy could be a feasible and efficacious treatment in highly advanced cases of liver dysfunction

KofamKOALA: KEGG ortholog assignment based on profile HMM and adaptive score threshold

Summary: KofamKOALA is a web server to assign KEGG Orthologs (KOs) to protein sequences by homology search against a database of profile hidden Markov models (KOfam) with pre-computed adaptive score thresholds. KofamKOALA is faster than existing KO assignment tools with its accuracy being comparable to the best performing tools. Function annotation by KofamKOALA helps linking genes to KEGG resources such as the KEGG pathway maps and facilitates molecular network reconstruction. Availability and implementation: KofamKOALA, KofamScan and KOfam are freely available from GenomeNet (https://www.genome.jp/tools/kofamkoala/). Supplementary information: Supplementary data are available at Bioinformatics online

微分方程式による磁界分布の可視化

A novel methodology is proposed to visualize the electromagnetic vector fields. First, in order to apply the field theory of computer graphics proposed in this paper, an electromagnetic field vector is represented as a color image. According to our theory, the high-resolution image can be generated in accordance with like a natural phenomenon. Consequently, it is possible to obtain more precise electromagnetic field from the poor measured data. Secondary, we have applied our method to the practically experimented magnetic fields. As a result, validity of our method has been verified.本論文では、画像処理の一方法とそれを応用した電磁界ベクトルフィールドの可視化方法を提案する。第１に、本論文で提案する画像処理方法を電磁界分布解析へ応用するために、３次元ベクトルフィールドをカラー画像で表現する。そこで得られる画像を偏微分方程式で記述し、その方程式を解くことであらゆる画素数の画像を生成する。結果として、測定点数の少ないデータからより詳細な電磁界分布データが得られる。第２に、検証実験として、高周波駆動を前提とするフィルム状変圧器を用いたDC/DCコンバータ周辺に分布する磁界を測定し、本手法を適応する

Localization of hepatitis C virus RNA in human liver biopsies by in situ hybridization using thymine-thymine dimerized oligo DNA probes: improved method.

To establish the most proper method of in situ hybridization in detection of HCV-RNA in the liver, various detailed procedures were examined using frozen as well as paraffin-embedded sections of tissue derived from patients. In frozen sections of the liver from hepatitis C patients obtained at autopsy or surgery, HCV-RNA was detectable by in situ hybridization using thymine-thymine dimerized oligonucleotide DNA probes when the sections were treated with ethanol-acetic acid at first, then 0.2 N hydrochloric acid, proteinase K (0.02 u/ml) and DNase. When the paraffin-embedded liver sections were used, more intense proteinase K treatment (0.2-2 u/ml) was required to expose viral RNA and even after that, the positive HCV-RNA signals were less than those in frozen sections, because the cytoplasmic RNA in the routine paraffin-embedded sections was preserved unevenly and less than in frozen sections. These findings indicate that in situ hybridization of HCV-RNA is useful for diagnosing HCV infection and should be a potent tool for monitoring the state of virus activities during therapy. However, the liver biopsy method should be modified so that RNA is retained properly to utilize biopsies more effectively for the routine diagnosis of HCV infection.</p

Surface Photovoltage Monitoring of Heavy Metal Contamination on Silicon During Chemical Cleaning in IC Manufacturing

The principles and application examples of recently refined，computerized surface photovoltage (SPV) method are described. The SPV method was used to optimize cleaning efficiency and to monitor \u27in-line\u27 heavy metal contamination and charge during critical processing steps for Statistical Process Control (SPC). Examples of the optimization of various cleaning steps，effects of the purity of virgin and reused chemicals， and the surface topology on cleaning efficiency will be given together with examples of SPC monitoring of real problems in processing lines. Cleanliness of incoming chemicals is not always a limiting factor and often is not related to the cleanliness of chemicals at the point of use (in the cleaning station). This new method is capable of waferscale，non- contact mapping of metal contaminants in the bulk and on the surface with sensitivities as high as 10¹⁰atoms cm-³

Anodic Oxidation of Narrow Region of Silicon Substrate

Anodic oxide films were formed on comparatively small area of silicon substrates. Constant current mode of anodization has been used for oxidation，but during oxidation processes，the current density has been changed to go through one or more stepped transitions either step-up or step-down before the completion of the processes. This modified mode of constant current anodization showed to be effective in reducing the interface state density of a silicon/silicon-oxide system. Among the various stepped transitions in the modified mode of constant current anodization，step-down transition of current density was found to be optimum in reducing the interface-state density. The structure and composition of SiO₂/Si interface regions for both large-area oxide and narrow-area oxide were also investigated by X-ray photoelectron spectroscopy (XPS). The composition of SiO₂/Si interface of narrowarea oxide showed less stoichiometry than that of large-area oxide

Impacts of ocean acidification and iron enrichment on photosynthetic ability of diatoms in the Bering Sea as estimated from their rbcL gene expressions

第2回極域科学シンポジウム　共通セッション「海氷圏の生物地球化学」 11月16日（水） 統計数理研究所 3階リフレッシュフロ