Effects of Imipramine and Lithium on the Suppression of Cell Proliferation in the Dentate Gyrus of the Hippocampus in Adrenocorticotropic Hormone-treated Rats

We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH

Deployment of an Autonomous Underwater Vehicle in Ice-covered Sea of Okhotsk : The First Japanese Challenge

第3回極域科学シンポジウム/第35回極域気水圏シンポジウム 11月29日（木） 国立国語研究所 ２階多目的

Geochemical characteristics of back-arc basin lower crust and upper mantle at final spreading stage of Shikoku Basin: an example of Mado Megamullion

AbstractThis paper explores the evolutional process of back-arc basin (BAB) magma system at final spreading stage of extinct BAB, Shikoku Basin (Philippine Sea) and assesses its tectonic evolution using a newly discovered oceanic core complex, the Mado Megamullion. Bulk and in-situ chemical compositions together with in-situ Pb isotope composition of dolerite, oxide gabbro, gabbro, olivine gabbro, dunite, and peridotite are presented. Compositional ranges and trends of the igneous and peridotitic rocks from the Mado Megamullion are similar to those from the slow- to ultraslow-spreading mid-ocean ridges (MOR). Since the timing of the Mado Megamullion exhumation corresponds to the very end of the Shikoku Basin opening, the magma supply was subdued and highly episodic, leading to extreme magma differentiation to form ferrobasaltic, hydrous magmas. In-situ Pb isotope composition of magmatic brown amphibole in the oxide gabbro is identical to that of depleted source mantle for mid-ocean ridge basalt (MORB). In the context of hydrous BAB magma genesis, the magmatic water was derived solely from the MORB source mantle. The distance from the back-arc spreading center to the arc front increased away through maturing of the Shikoku Basin to cause MORB-like magmatism. After the exhumation of Mado Megamullion along detachment faults, dolerite dikes intruded as a post-spreading magmatism. The final magmatism along with post-spreading Kinan Seamount Chain volcanism were introduced around the extinct back-arc spreading center after the opening of Shikoku Basin by residual mantle upwelling

Chronological constraints on the Paleoproterozoic Francevillian Group in Gabon

The Francevillian Group in Gabonese Republic was recently established as a typical sedimentary sequence for the Paleoproterozoic. However, its age is rather poorly constrained, mainly based on Rb-Sr and Nd-Sm datings. This study reports new zircon data obtained from Chaillu massif and N'goutou complex, which constrain the protolith age of the basement orthogneisses and the igneous age of an intrusive granite, respectively. Most zircons from the orthogneisses are blue and exhibit oscillatory zoning in cathode-luminescence images. Zircons with lower common lead abundances tend to be distributed close to the concordia curve. Two age clusters around 2860 Ma and 2910 Ma are found in zircons plotted on the concordia curve. Based on the Th/U ratios of zircons, these ages correspond to the protolith ages of the orthogneisses, and the zircons are not metamorphic in origin. Syenites and granites were collected from the N'goutou complex that intrudes into the FA and FB units of the Francevillian Group. The granitoids exhibit chemical composition of A-type granite affinity. Half of zircons separated from the granite are non-luminous, and the remaining half exhibit obscure internal textures under cathode-luminescence observation. All zircon grains contain significant amounts of common lead; the lead isotopic variability is probably attributed to the mixing of two components in the zircons. The zircon radiogenic 207Pb/206Pb ratio is 0.13707 ± 0.0010, corresponding to a 207Pb/206Pb age of 2191 ± 13 Ma. This constrains the minimum depositional age of the FA and FB units. Furthermore, the FB unit consists of manganese-rich carbonate rocks and organic carbon-rich black shales with macroscopic fossils. Based on our age constraints, these organisms appeared in the study area just after the last Paleoproterozoic Snowball Earth event, in concert with global scale oxidation event encompassing the Snowball Earth