A Case Report of Lipid-Rich Carcinoma of the Breast Including Histological Characteristics and Intrinsic Subtype Profile

A 57-year-old Japanese woman with schizophrenia, who had received long-term treatment with neuroleptics, noticed a painless, pea-sized lump in her right breast. She was admitted to our hospital and a malignant tumor was diagnosed. The patient underwent a conservative radical mastectomy (Patey's operation). The excised tumor measured 2.0 × 1.2 × 1.1 cm in diameter, and its cut surface was grayish-white. Histologically, tumor cells with clear to foamy cytoplasm were invariably Oil Red O-positive and periodic acid Schiff-negative with or without diastase digestion. The tumor was diagnosed as a lipid-rich carcinoma accompanied by an in situ component. Neuroleptics increase serum prolactin levels by interfering with dopaminergic inhibition of prolactin secretion. Immunohistochemical analysis revealed that, although prolactin was not detected, the tumor cells expressed prolactin receptor, indicating prolactin as the genesis of this neoplasm. In immunohistochemical intrinsic subtype analysis, the tumor was negative for estrogen receptor, progesterone receptor, human epidermal growth factor receptor 1 and 2, and basal cytokeratins (CK5, CK6, and CK14), indicating an unclassified (all-marker negative) subtype. Axillary lymph nodes were free of metastasis (stage I), and the patient has been well for 20 years without any evidence of recurrence

Subaru Deep Survey V. A Census of Lyman Break Galaxies at z=4 and 5 in the Subaru Deep Fields: Photometric Properties

(abridged) We investigate photometric properties of Lyman Break Galaxies (LBGs) at z=3.5-5.2 based on large samples of 2,600 LBGs detected in deep (i'~27) and wide-field (1,200 arcmin^2) images taken in the Subaru Deep Field (SDF) and the Subaru/XMM Deep Field (SXDF). The selection criteria for the LBG samples are examined with 85 spectroscopically identified objects and by Monte Carlo simulations. We find in the luminosity functions of LBGs (i) that the number density of bright galaxies (M_{1700}<-22; corresponding to SFR_{corr}>100 Msolar yr^{-1}) decreases significantly from z=4 to 5 and (ii) that the faint-end slope of the luminosity function may become steeper towards higher redshifts. We estimate dust extinction of z=4 LBGs with M<M^* from UV slopes, and obtain E(B-V)=0.15+/-0.03 as the mean value. The dust extinction remains constant with apparent luminosity, but increases with intrinsic luminosity. We find no evolution in dust extinction between LBGs at z=3 and 4. We investigate the evolution of UV-luminosity density at 1700A, rho, and find that rho does not significantly change from z=3 to z=5, i.e., rho(z=4)/rho(z=3)=1.0+/-0.2 and rho(z=5)/rho(z=3)=0.8+/-0.4, thus the cosmic star-formation rate (SFR) density remains constant. We find that the stellar mass density estimated from the cosmic SFR is consistent with those derived directly from the stellar mass function at z=0-1, but exceeds those at z~3 by a factor of 3. We find that the ratio of the UV-luminosity density of Ly-a emitters (LAEs) to that of LBGs is ~60% at z=5, and thus about a half of the star formation at z=5 probably occurs in LAEs. We obtain a constraint on the escape fraction of UV-ionizing photons produced by LBGs, f_{esc}>~0.13.Comment: 41 pages, 22 figures, ApJ in press. Paper with high resolution figures is available at http://hikari.astron.s.u-tokyo.ac.jp/~ouchi/work/astroph/SDS_V_VI/SDS_V.pdf (PDF

N -Ethyl- N -Nitrosourea Induces Retinal Photoreceptor Damage in Adult Rats

Seven-week-old male Lewis rats received a single intraperitoneal injection of N-ethyl-N-nitrosourea (ENU) (100, 200, 400 or 600 mg/kg), and retinal damage was evaluated 7 days after the treatment. Sequential morphological features of the retina and retinal DNA damage, as determined by a TUNEL assay and phospho-histone H2A.X (γ-H2AX), were analyzed 3, 6, 12, 24 and 72 hr, 7 days, and/or 30 days after 400 mg/kg ENU treatment. Activation of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) was analyzed immunohistochemically by poly (ADP-ribose) (PAR) expression in response to DNA damage of the retina. All rats that received ≥ 400 mg/kg of ENU developed retinal degeneration characterized by the loss of photoreceptor cells in both the central and peripheral retina within 7 days. In the 400 mg/kg ENU-treated rats, TUNEL-positive signals were only located in the photoreceptor cells and peaked 24 hr after ENU treatment. The γ-H2AX signals in inner retinal cells appeared at 24 hr and peaked at 72 hr after ENU treatment, and the PAR signals selectively located in the photoreceptor cell nuclei appeared at 12 hr and peaked at 24 hr after ENU treatment. However, degeneration was restricted to photoreceptor cells, and no degenerative changes in inner retinal cells were seen at any time points. Retinal thickness and the photoreceptor cell ratio in the central and peripheral retina were significantly decreased, and the retinal damage ratio was significantly increased 7 days after ENU treatment. In conclusion, ENU induced retinal degeneration in adult rats that was characterized by photoreceptor cell apoptosis through PARP activity

Cosmic shear statistics in the Suprime-Cam 2.1 sq deg field: Constraints on Omega_m and sigma_8

We present measurements of the cosmic shear correlation in the shapes of galaxies in the Suprime-Cam 2.1 deg^2 R_c-band imaging data. As an estimator of the shear correlation originated from the gravitational lensing, we adopt the aperture mass variance. We detect a non-zero E mode variance on scales between 2 and 40arcmin. We also detect a small but non-zero B mode variance on scales larger than 5arcmin. We compare the measured E mode variance to the model predictions in CDM cosmologies using maximum likelihood analysis. A four-dimensional space is explored, which examines sigma_8, Omega_m, Gamma and zs (a mean redshift of galaxies). We include three possible sources of error: statistical noise, the cosmic variance estimated using numerical experiments, and a residual systematic effect estimated from the B mode variance. We derive joint constraints on two parameters by marginalizing over the two remaining parameters. We obtain an upper limit of Gamma0.9 (68% confidence). For a prior Gamma\in[0.1,0.4] and zs\in[0.6,1.4], we find sigma_8=(0.50_{-0.16}^{+0.35})Omega_m^{-0.37} for flat cosmologies and sigma_8=(0.51_{-0.16}^{+0.29})Omega_m^{-0.34}$ for open cosmologies (95% confidence). If we take the currently popular LCDM model, we obtain a one-dimensional confidence interval on sigma_8 for the 95.4% level, 0.62<\sigma_8<1.32 for zs\in[0.6,1.4]. Information on the redshift distribution of galaxies is key to obtaining a correct cosmological constraint. An independent constraint on Gamma from other observations is useful to tighten the constraint.Comment: 12 pages, 12 figures, accepted for publication in Ap

Clustering Properties of Galaxies at z~4 in the Subaru/XMM Deep Survey Field

We study the clustering properties of about 1200 z~4 Lyman Break Galaxy (LBG) candidates with i'<26 which are selected by color from deep BRi' imaging data of a 618 arcmin^2 area in the Subaru/XMM-Newton Deep Field taken with Subaru Prime Focus Camera. The contamination and completeness of our LBG sample are evaluated, on the basis of the Hubble Deep Field North (HDFN) objects, to be 17% and 45%, respectively. We derive the angular correlation function over theta = 2''-1000'', and find that it is fitted fairly well by a power law, omega(theta)=A_omega theta^{-0.8}, with A_omega = 0.71 +/- 0.26. We then calculate the correlation length r0 (in comoving units) of the two-point spatial correlation function xi(r) = (r/r0)^{-1.8} from A_omega using the redshift distribution of LBGs derived from the HDFN, and find r0=2.7 (+0.5/-0.6) h^{-1} Mpc in a Lambda-dominated universe (Omega_m=0.3 and Omega_Lambda=0.7). This is twice larger than the correlation length of the dark matter at z~4 predicted from an analytic model by Peacock & Dodds but about twice smaller than that of bright galaxies predicted by a semi-analytic model of Baugh et al. We find an excess of omega(theta) on small scales (theta < 5'') departing from the power law fit over 3 sigma significance levels. Interpreting this as due to galaxy mergers, we estimate the fraction of galaxies undergoing mergers in our LBG sample to be 3.0 +/- 0.9%, which is significantly smaller than those of galaxies at intermediate redshifts.Comment: 9 pages, 4 figures, to be published in ApJ Letter