Tumors Sharply Increased after Ceasing Pazopanib Therapy for a Patient with Advanced Uterine Leiomyosarcoma: Experience of Tumor Flare

Pazopanib has activity in patients with soft-tissue sarcoma. We report an advanced uterine leiomyosarcoma case that suddenly worsened after cessation of pazopanib therapy. A 47-year-old woman had a primary uterine leiomyosarcoma tumor and multiple lung metastases, which progressed during her initial treatment. In subsequent treatment with pazopanib for 3 months, the sum of her tumor diameters after cessation sharply increased for two weeks. Symptoms such as dyspnea suddenly worsened also. She died of the disease one month after cessation of pazopanib therapy. Given the poor prognosis of recurrent uterine leiomyosarcoma and the rapid tumor enlargement after ending pazopanib therapy, control of this disease is especially important. Therefore, the decision to discontinue pazopanib therapy requires careful consideration

Surface Analysis of Ionic Liquids with and without Lithium Salt Using X‑ray Photoelectron Spectroscopy

X-ray photoelectron spectroscopy (XPS) was applied to a neat ionic liquid 1-ethyl-3-methylimidazolium bis­(trifluoromethanesulfonyl)­imide [EMI⁺]­[Tf₂N^–] and its lithium salt solution at room temperature to clarify the composition and structure of its near-surface region. Core level peaks were recorded for Li 1s, N 1s, C 1s, F 1s, O 1s, S 2s, and S 2p. Valence band XPS spectra (0–40 eV binding energy) were also studied. The XPS spectra were analyzed using DV-Xα calculations. Results show that the planar type isomer of the EMI⁺ cation is dominant at the near-surface region of EMI-Tf₂N. Results of XPS measurements show a spectrum of Li 1s in Li/EMI-Tf₂N. The proposed models for the preferred orientation of the ions exhibit good agreement with results obtained from the DV-Xα calculations

Skin Temperature Changes of Receivers Laogong on the Left Hand in Remote Action Experiment(II)

ECG analysis was done for a qi-receiver during Toh-ate (remote action; an ancient Japanese martial art) with double blind. Two practitioners were isolated in two rooms under the condition of cutting normal information transfer. One practitioner (sender) sent qi randomly once par trial of 80 seconds and the other (receiver) tried to perceive the qi; at the time he perceived it, he pushed a switch. Their sending times, receiving times and physiological data were recorded during the experiments. The receiver\u27s ECG R-R intervals were measured, and their fluctuations before and after the sending times were analyzed. As a result, in a group of trials without the receiver\u27s switch signals, the coefficient of variation of R-R intervals for 10 seconds after the sending times was larger by a statistically significant amount (1%) than before them.第１３回生命情報科学シンポジウ

Skin Temperature Changes of Receivers Laogong on the Left Hand in Remote Action Experiment(II)

Two persons who have a 40-year history as a pair practicing a martial art which front-detects a partner\u27s attack sign performed remote action experiment a total of 4 times over 2 years. In all runs, the two subjects were in two different rooms, and the sender emitted a qi of attack only once during an 80-second trial under double blinded and randomized conditions. In this report, the temperature data of the second experimental series were analyzed and tested. The difference between the average temperature changes during a period of 2 seconds before the 1 second of sending was statistically significant at 5% or less. The time of change was the same as in part I which analyzed the first experimental series. Then, the differences between three large peaks which occurred around -41 (p=3.7%) sec (peak I), 0 sec (13.4) (peak II), +36 sec (1.3) (peak III) in the frequency histogram which Yamamoto 8) reported were also analyzed and tested. PeakII showed a statistically significant value of 1% or less between the difference of the average temperature change near the sending time, however there was no significance near peaks I and III