NMR study of the layered cobalt oxyphosphide Sr2Sc(Co1-xFex)PO3

We report the results of 31P-nuclear magnetic resonance (NMR) measurements on the layered cobalt oxyphosphide Sr2Sc(Co1−xFex)PO3 in order to investigate the magnetic properties at low temperatures from a microscopic view point. The 31P-Knight shifts measured at the resonance peak maximum of Sr2Sc(Co1−xFex)PO3 have positive values and are T-independent in an entire temperature range, and the absolute value decreases with increasing Fe content. Also, the nuclear spin-lattice relaxation rate 1/T1 is almost proportional to the temperature at low temperatures. The magnitude of 1/T1T decreases with increasing the Fe content, which suggests the decrease of the density of states around the Fermi level

Oxidation and reduction effects of successive superconducting transitions in ultra-fine YBa2Cu4O8 ceramics

We investigated the effects of oxidation and reduction on the successive superconducting transition in a ceramic material composed of YBa2Cu4O8 (Y124) submicron grains by linear and non-linear resistivity measurements. This material shows two-step superconducting transition and the lower one is identified as an inter-grain ordering. A sintering process fuses and joins the adjacent grains, so the lower transition was suppressed with increasing sintered time. Although Y124 is a stoichiometric ceramic, a reduction treatment suppressed the temperature of zero resistivity and broadened the non-linear resistivity peak. This suggests an oxygen vacancy was induced on the grain surface

Magnetic Field–Temperature Phase Diagram of Fine YBa2Cu3O7−δ Ceramics from Linear and Non-linear Resistivities

We performed linear and non-linear resistivity measurements for fine YBa2Cu3O7−δ ceramics under magnetic field. Successive superconducting transition was observed in the linear resistivity and the lower temperature part of the resistivity curve became convex upward at high fields. A non-linear resistivity peak was observed for this lower temperature region and its offset temperature Toffset and the onset temperature Tonest coincided with the temperature of zero resistivity and inflexion point in linear resistivity, respectively. At lower field, Tonset was less sensitive to the field than Toffset, which implies the existence of the peculiar inter-grain ordering phase at finite fields.2019 International Conference on Strongly Correlated Electron Systems (SCES2019), September 23-28, 2019, Okayama Convention Center in Okayama, Japa

Oxaliplatin for Metastatic Colon Cancer in a Patient with Renal Failure

The efficacy, safety, pharmacokinetics, and dialysability of oxaliplatin were assessed in a hemodialysis patient with recurrent cecal cancer

Inter-grain Phase Transitions in Superconducting Ceramic YBa2Cu3O7−δ under Low Magnetic Fields

We investigated the magnetic field dependence of inter-grain phase transitions in the ceramic YBa2Cu3O7−δ. To this end, we measured the temperature dependences of the nonlinear magnetic responses and the current–voltage characteristics under low magnetic fields. We then estimated the inter-grain temperatures of the glass and superconducting transitions. The field–temperature phase diagram of the inter-grain ordering was similar to that of YBa2Cu4O8 ceramic. The results imply the occurrence of chiral-glass ordering in ceramic cuprate superconductors under low magnetic fields.2019 International Conference on Strongly Correlated Electron Systems (SCES2019), September 23-28, 2019, Okayama Convention Center in Okayama, Japa

Altered Host Immunity, Human T Lymphotropic Virus Type I Replication, and Risk of Adult T-Cell Leukemia/Lymphoma: A Prospective Analysis from the ATL Cohort Consortium

Background: Adult T-cell leukemia/lymphoma (ATL) is a rare and often fatal outcome of infection with human T-lymphotropic virus type I (HTLV-I). Altered host immunity in HTLV-I carriers has been postulated as a risk factor for ATL, but is not well understood. Methods: We prospectively examined well-validated serologic markers of HTLV-I pathogenesis and host immunity in 53 incident ATL cases and 150 carefully matched asymptomatic HTLV-I carriers from eight population-based studies in Japan, Jamaica, the United States and Brazil. We used multivariable conditional logistic regression, conditioned on the matching factors (cohort/race, age, sex, and sample collection year), to evaluate the biomarkers’ associations with ATL in all subjects and by years (≤5, >5) from blood draw to ATL diagnosis. Results: In the pooled population, above-median soluble interleukin-2-receptor-alpha levels (sIL2R, v. ≤ median; odds ratio (OR), 95% confidence interval (CI)=4.08, 1.47-11.29) and anti-Tax seropositivity (anti-Tax; OR, 95% CI=2.97, 1.15-7.67), which indicate T cell activation and HTLV-I replication, respectively, were independently associated with an increased ATL risk. Above-median total immunoglobulin E levels (v. ≤ median; OR, 95% CI=0.45, 0.19-1.06), which indicate type 2 (B cell) activation, predicted a lower ATL risk. The sIL2R and anti-Tax associations with ATL were stronger in samples collected ≤5 years pre-diagnosis. Conclusions: The biomarker profile predictive of ATL risk suggests a role for heightened T cell activation and HTLV-I replication and diminished type 2 immunity in the etiology of ATL in HTLV-I carriers. Translation of these findings to clinical risk prediction or early ATL detection requires further investigation. Acknowledgements: This abstract is presented on behalf of the ATL Cohort Consortium