Is the immediate effect of marathon running on novice runners' knee joints sustained within 6 months after the run? A follow-up 3.0 T MRI study.

OBJECTIVE: To evaluate changes in the knee joints of asymptomatic first-time marathon runners, using 3.0 T MRI, 6 months after finishing marathon training and run. MATERIALS AND METHODS: Six months after their participation in a baseline study regarding their knee joints, 44 asymptomatic novice marathoners (17 males, 27 females, mean age 46 years old) agreed to participate in a repeat MRI investigation: 37 completed both a standardized 4-month-long training programme and the marathon (marathon runners); and 7 dropped out during training (pre-race dropouts). The participants already underwent bilateral 3.0 T MRIs: 6 months before and 2 weeks after their first marathon, the London Marathon 2017. This study was a follow-up assessment of their knee joints. Each knee structure was assessed using validated scoring/grading systems at all time points. RESULTS: Two weeks after the marathon, 3 pre-marathon bone marrow lesions and 2 cartilage lesions showed decrease in radiological score on MRI, and the improvement was sustained at the 6-month follow-up. New improvements were observed on MRI at follow-up: 5 pre-existing bone marrow lesions and 3 cartilage lesions that remained unchanged immediately after the marathon reduced in their extent 6 months later. No further lesions appeared at follow-up, and the 2-week post-marathon lesions showed signs of reversibility: 10 of 18 bone marrow oedema-like signals and 3 of 21 cartilage lesions decreased on MRI. CONCLUSION: The knees of novice runners achieved sustained improvement, for at least 6 months post-marathon, in the condition of their bone marrow and articular cartilage

S-Duality at the Black Hole Threshold in Gravitational Collapse

We study gravitational collapse of the axion/dilaton field in classical low energy string theory, at the threshold for black hole formation. A new critical solution is derived that is spherically symmetric and continuously self-similar. The universal scaling and echoing behavior discovered by Choptuik in gravitational collapse appear in a somewhat different form. In particular, echoing takes the form of SL(2,R) rotations (cf. S-duality). The collapse leaves behind an outgoing pulse of axion/dilaton radiation, with nearly but not exactly flat spacetime within it.Comment: 8 pages of LaTeX, uses style "revtex"; 1 figure, available in archive, or at ftp://ftp.itp.ucsb.edu/figures/nsf-itp-95-15.ep

Tracing the Ingredients for a Habitable Earth from Interstellar Space through Planet Formation

We use the C/N ratio as a monitor of the delivery of key ingredients of life to nascent terrestrial worlds. Total elemental C and N contents, and their ratio, are examined for the interstellar medium, comets, chondritic meteorites and terrestrial planets; we include an updated estimate for the Bulk Silicate Earth (C/N = 49.0 +/- 9.3). Using a kinetic model of disk chemistry, and the sublimation/condensation temperatures of primitive molecules, we suggest that organic ices and macro-molecular (refractory or carbonaceous dust) organic material are the likely initial C and N carriers. Chemical reactions in the disk can produce nebular C/N ratios of ~1-12, comparable to those of comets and the low end estimated for planetesimals. An increase of the C/N ratio is traced between volatile-rich pristine bodies and larger volatile-depleted objects subjected to thermal/accretional metamorphism. The C/N ratios of the dominant materials accreted to terrestrial planets should therefore be higher than those seen in carbonaceous chondrites or comets. During planetary formation, we explore scenarios leading to further volatile loss and associated C/N variations owing to core formation and atmospheric escape. Key processes include relative enrichment of nitrogen in the atmosphere and preferential sequestration of carbon by the core. The high C/N BSE ratio therefore is best satisfied by accretion of thermally processed objects followed by large-scale atmospheric loss. These two effects must be more profound if volatile sequestration in the core is effective. The stochastic nature of these processes hints that the surface/atmospheric abundances of biosphere-essential materials will likely be variable.Comment: Accepted by PNAS per http://www.pnas.org/content/early/2015/07/01/1500954112.abstract?sid=9fd8abea-9d33-46d8-b755-217d10b1c24

Fruit characteristics and cuticle triterpenes as related to postharvest quality of highbush blueberries

Chilean fresh blueberries take 20-50 days to arrive by boat to the Northern hemisphere, softening and dehydration being the main defects upon arrival. The effect of maturity at harvest (75% blue, 100% blue, and overripe) on cuticular triterpene content, and the possible associated impacts on firmness and weight loss after cold storage were explored for 'Duke' and 'Brigitta' fruit, both non-bagged or bagged in macroperforated low-density polyethylene bags. Softening and weight loss varied with cultivar and maturity stage: 'Duke' fruit softened faster and were more prone to dehydration than 'Brigitta' samples, whereas overripe fruit were less firm after storage. This is the first report characterizing the triterpenoid fraction in cuticles of fresh blueberries, which may play a role in their postharvest behavior. Weight loss and softening rates were highly correlated to ursolic acid contents at harvest; further research will be required for a better understanding of these relationships.Fruit samples were provided by AMS Family, Maule Region, Chile. We thank Irene Manríquez, Instituto de Química de Recursos Naturales, Universidad de Talca, for her skillful technical work. In Chile, this work was supported by the National Commission for Scientific and Technological Research CONICYT (FONDECYT 11130539) and PCHA/Doctorado Nacional/2013-63130042, the research programs “Adaptation of Agriculture to Climate Change (A2C2)”, “PIEI-QUIM-BIO”, “Fondo Proyectos de Investigación” and “Núcleo Científico Multidisciplinario”, Universidad de Talca. In Spain this work was partially supported by “Fundación Carolina” and “Programa de Doctorado en Ciencia y Tecnología Agraria y Alimentaria”, Universitat de Lleida

Perturbations and Critical Behavior in the Self-Similar Gravitational Collapse of a Massless Scalar Field

This paper studies the perturbations of the continuously self-similar critical solution of the gravitational collapse of a massless scalar field (Roberts solution). The perturbation equations are derived and solved exactly. The perturbation spectrum is found to be not discrete, but occupying continuous region of the complex plane. The renormalization group calculation gives the value of the mass-scaling exponent equal to 1.Comment: 12 pages, RevTeX 3.1, 1 figur

Critical Collapse of a Complex Scalar Field with Angular Momentum

We report a new critical solution found at the threshold of axisymmetric gravitational collapse of a complex scalar field with angular momentum. To carry angular momentum the scalar field cannot be axisymmetric; however, its azimuthal dependence is defined so that the resulting stress energy tensor and spacetime metric are axisymmetric. The critical solution found is non-spherical, discretely self-similar with an echoing exponent of 0.42 (+- 4%), and exhibits a scaling exponent of 0.11 (+- 10%) in near critical collapse. Our simulations suggest that the solution is universal (within the imposed symmetry class), modulo a family-dependent constant phase in the complex plane.Comment: 4 pages, 4 figure

Criticality and Bifurcation in the Gravitational Collapse of a Self-Coupled Scalar Field

We examine the gravitational collapse of a non-linear sigma model in spherical symmetry. There exists a family of continuously self-similar solutions parameterized by the coupling constant of the theory. These solutions are calculated together with the critical exponents for black hole formation of these collapse models. We also find that the sequence of solutions exhibits a Hopf-type bifurcation as the continuously self-similar solutions become unstable to perturbations away from self-similarity.Comment: 18 pages; one figure, uuencoded postscript; figure is also available at http://www.physics.ucsb.edu/people/eric_hirschman

Prevalence of abnormal findings in 230 knees of asymptomatic adults using 3.0 T MRI.

OBJECTIVE: To identify abnormalities in asymptomatic sedentary individuals using 3.0 Tesla high-resolution MRI. MATERIALS AND METHODS: The cohort comprised of 230 knees of 115 uninjured sedentary adults (51 males, 64 females; median age: 44 years). All participants had bilateral knee 3.0 T MRIs. Two senior musculoskeletal radiologists graded all intraarticular knee structures using validated scoring systems. Participants completed Knee Injury and Osteoarthritis Outcome Score questionnaires at the time of the MRI scan. RESULTS: MRI showed abnormalities in the majority (97%) of knees. Thirty percent knees had meniscal tears: horizontal (23%), complex (3%), vertical (2%), radial (2%) and bucket handle (1%). Cartilage and bone marrow abnormalities were prevalent at the patellofemoral joint (57% knees and 48% knees, respectively). Moderate and severe cartilage lesions were common, in 19% and 31% knees, respectively, while moderate and severe bone marrow oedema in 19% and 31% knees, respectively. Moderate-intensity lesion in tendons was found in 21% knees and high-grade tendonitis in 6% knees-the patellar (11% and 2%, respectively) and quadriceps (7% and 2%, respectively) tendons being most affected. Three percent partial ligamentous ruptures were found, especially of the anterior cruciate ligament (2%). CONCLUSION: Nearly all knees of asymptomatic adults showed abnormalities in at least one knee structure on MRI. Meniscal tears, cartilage and bone marrow lesions of the patellofemoral joint were the most common pathological findings. Bucket handle and complex meniscal tears were reported for the first time in asymptomatic knees

Simulating binary neutron stars: dynamics and gravitational waves

We model two mergers of orbiting binary neutron stars, the first forming a black hole and the second a differentially rotating neutron star. We extract gravitational waveforms in the wave zone. Comparisons to a post-Newtonian analysis allow us to compute the orbital kinematics, including trajectories and orbital eccentricities. We verify our code by evolving single stars and extracting radial perturbative modes, which compare very well to results from perturbation theory. The Einstein equations are solved in a first order reduction of the generalized harmonic formulation, and the fluid equations are solved using a modified convex essentially non-oscillatory method. All calculations are done in three spatial dimensions without symmetry assumptions. We use the \had computational infrastructure for distributed adaptive mesh refinement.Comment: 14 pages, 16 figures. Added one figure from previous version; corrected typo

Relativistic MHD with Adaptive Mesh Refinement

This paper presents a new computer code to solve the general relativistic magnetohydrodynamics (GRMHD) equations using distributed parallel adaptive mesh refinement (AMR). The fluid equations are solved using a finite difference Convex ENO method (CENO) in 3+1 dimensions, and the AMR is Berger-Oliger. Hyperbolic divergence cleaning is used to control the $\nabla\cdot {\bf B}=0$ constraint. We present results from three flat space tests, and examine the accretion of a fluid onto a Schwarzschild black hole, reproducing the Michel solution. The AMR simulations substantially improve performance while reproducing the resolution equivalent unigrid simulation results. Finally, we discuss strong scaling results for parallel unigrid and AMR runs.Comment: 24 pages, 14 figures, 3 table