Development and Congenital Anomalies of the Pancreas

Understanding how the pancreas develops is essential to understand the pathogenesis of congenital pancreatic anomalies. Recent studies have shown the advantages of investigating the development of frogs, mice, and chickens for understanding early embryonic development of the pancreas and congenital anomalies, such as choledochal cysts, anomalous pancreaticobiliary junction, annular pancreas, and pancreas divisum. These anomalies arise from failure of complete rotation and fusion during embryogenesis. There are many theories in the etiology of congenital anomalies of the pancreas. We review pancreas development in humans and other vertebrates. In addition, we attempt to clarify how developmental failure is related to congenital pancreatic anomalies

Zero-Shot Edge Detection with SCESAME: Spectral Clustering-based Ensemble for Segment Anything Model Estimation

This paper proposes a novel zero-shot edge detection with SCESAME, which stands for Spectral Clustering-based Ensemble for Segment Anything Model Estimation, based on the recently proposed Segment Anything Model (SAM). SAM is a foundation model for segmentation tasks, and one of the interesting applications of SAM is Automatic Mask Generation (AMG), which generates zero-shot segmentation masks of an entire image. AMG can be applied to edge detection, but suffers from the problem of overdetecting edges. Edge detection with SCESAME overcomes this problem by three steps: (1) eliminating small generated masks, (2) combining masks by spectral clustering, taking into account mask positions and overlaps, and (3) removing artifacts after edge detection. We performed edge detection experiments on two datasets, BSDS500 and NYUDv2. Although our zero-shot approach is simple, the experimental results on BSDS500 showed almost identical performance to human performance and CNN-based methods from seven years ago. In the NYUDv2 experiments, it performed almost as well as recent CNN-based methods. These results indicate that our method effectively enhances the utility of SAM and can be a new direction in zero-shot edge detection methods.Comment: 11 pages, accepted to WACV 2024 Worksho

Contact Analysis and Simulation of Rolled Plastic Film Used for Roof Ventilation in Japanese Greenhouses

Greenhouses are capable of producing a variety of high-value crops year-round. A novel Japanese greenhouse design is gaining popularity because of its automated roll-up ventilation system that is integrated into the roof. However, due to the frequent movement of the roll-up system, the plastic film deteriorates rapidly and typically lasts for only three or four months. In order to better understand the film deterioration, we studied the mechanics involved at the point of contact between the film and the metal greenhouse frame. We found that film deformation and failure were closely related to stretching and creasing, and these processes were observed at the microscopic level. An experimental device was developed to further study the damage to greenhouse film due to the roll-up movement. We concluded that the reduction in film thickness due to static loading or rolling contact was the best predictor of future film damage

Gap between self-evaluation and actual hand hygiene compliance among health-care workers

Hand hygiene (HH) compliance among health-care workers has not satisfactorily improved despite multiple educative approaches. Between October 2019 and February 2020, we performed a self-evaluation test and a direct observation for the compliance of the 5 Moments for Hand Hygiene program advocated by the World Health Organization at two Japanese hospitals. Average percentages of self-evaluated HH compliance were as follows: (i) 76.9% for “Before touching a patient,” (ii) 85.8% for “Before clean/aseptic procedures,” (iii) 95.9% for “After body fluid exposure/risk,” (iv) 84.0% for “After touching a patient,” and (v) 69.2% for “After touching patient surroundings.” On the other hand, actual HH compliance was 11.7% for “Before touching a patient” and 18.0% for “After touching a patient or patient surroundings.” The present study demonstrated a big gap between self-evaluation and actual HH compliance among nurses working at hospitals, indicating the need of further providing the education in infection prevention

Semi-automatic retractable handrail utilizing opening/closing movement of sliding door supporting elderly people to walk independently

The purpose of this research is to install a handrail on the sliding doors used in hospitals and nursing facilities to support senior and people with disabilities to walk by themselves. The semi-automatic lifting equipment is utilized for the retractable handrail to make sure people in bad health are able to open the door using a weak force. To design the handrail for this purpose, the theoretical formula for opening force is derived. Then the simulation is performed with varying geometry conditions confirming the results are in good agreement with the experiment results. The opening force is designed to be less than the target value previously reported. The sliding door developed in this study is useful for elderly people walking by themselves safely.Peer Reviewe

Dietary Salt Intake is a Significant Determinant of Impaired Kidney Function in the General Population

Background/Aims: Kidney dysfunction is an important risk factor for cardiovascular disease and end-stage renal disease. This study investigated whether dietary salt intake predicts deterioration of kidney function in the general population. Methods: In all, 12 126 subjects with a normal estimated glomerular filtration rate (eGFR ≥60 mL/min per 1.73m2) attending an annual check-up were enrolled in the study and were followed-up for a median of 1754 days; the endpoint was the development of impaired kidney function (eGFR < 60 mL/min per 1.73m2). Individual salt intake was estimated using spot urine analysis. Results: At baseline, mean (± SD) salt intake and eGFR were 10.6 ± 3.4 g/day and 80.8 ± 12.9 mL/min per 1.73m2, respectively. During the follow-up period, 1384 subjects (25.2 per 1000 person-years) developed impaired kidney function. Multivariate Cox hazard regression analysis revealed salt intake as a significant predictor of the new onset of kidney impairment (hazard ratio 1.045; 95% confidence interval 1.025–1.065). Subjects were divided into two groups based on salt intake; the incidence of impaired kidney function was higher in the group with high than low salt intake (P < 0.001, log-rank test). Multivariate Cox hazard regression analysis indicated a 29% increased risk of developing impaired kidney function in the high-salt group. Multivariate linear regression analysis showed a significant correlation between salt intake and yearly decline in eGFR (β = 0.060, P < 0.001). Conclusion: Salt intake is associated with the development of impaired kidney function in the general population, independent of its effects on blood pressure. Salt restriction may help prevent the development of impaired kidney function

包括的凝固機能検査による急性期川崎病における止血動態の評価

Introduction: Kawasaki disease (KD) is a systemic vasculitis involving coronary arteries, sometimes resulting in aneurysms and myocardial infarction. Hyper-coagulability in the acute-phase of KD is indicated in some circumstances based on changes of individual clotting factors. Comprehensive coagulation assays, clot waveform analysis (CWA) and thrombin/plasmin generation assay (T/P-GA), have been developed to assess physiological hemostasis, but these techniques have not been applied in KD. Methods: We utilized both assays to analyze coagulation function in KD children (n = 42) prior to intravenous-immunoglobulin (IVIG) treatment (Pre), 1-week (1W) and 1-month (1M) post-IVIG. Results: In CWA, the clot time (CT) pre-treatment was prolonged, and was significantly shortened at 1W and 1M. However, the maximum coagulation velocity (|min1|) and acceleration (|min2|) were ~2-fold greater relative to controls, indicating an overall hypercoagulable tendency. These parameters were related to fibrinogen concentration, and were decreased at 1W and declined to normal at 1M. In T/P-GA, the endogenous potentials of thrombin and plasmin were greater relative to control at each of three time-points, and measurements at 1W were greater than those Pre-treatment. The ratios of TG and PG relative to control were similar, however, suggesting well-balanced dynamic coagulation and fibrinolysis. In non-responders to IVIG, the |min1| and |min2| measurements were greater than those in responders at 1W and 1M, suggesting that non-responders remained hypercoagulable after primary treatment. Conclusion: The coagulation data observed in KD were consistent with hypercoagulability, although fibrinolytic function appeared to be well-balanced. Comprehensive assays of this nature could provide valuable information on coagulation potential in KD.博士（医学）・乙第1441号・令和元年12月5日Copyright © 2018 Elsevier Ltd. All rights reserved