Kaplan-Meier curves for cardiac event-free rates in LHD-PH patients.

<p>The cardiac event-free rate significantly differed between PAC ≥ 2.48 and < 2.48 ml/mmHg, log BNP ≥ 2.18 and < 2.18, eGFR ≥ 50 and < 50 ml/min/1.73 cm², Hemoglobin ≥ 12 and < 12 mg/ml, and NYHA classification III/IV and I/II. To the contrary, no difference was observed in the cardiac event-free rate between mean RAP ≥ 10 and < 10 mmHg, PVR ≥ 2.5 and < 2.5 WU, TPG ≥ 12 and < 12 mmHg, DPG ≥ 7 and < 7 mmHg, and age ≥ 70 and < 70 years.</p

Kaplan-Meier curves for cardiac events according to quartiles of pulmonary arterial capacitance.

<p>Cumulative cardiac event-free rate was significantly lower in the 1^st quartile than the 2^nd, 3^rd, and 4^th quartiles.</p

Receiver-operating characteristic (ROC) curve for PAC for prediction of cardiac events in LHD-PH patients.

<p>AUC, area under the curve; CI, confidence interval. PAC, pulmonary arterial capacitance Pcw, pulmonary capillary wedge pressure; RAP, right atrial pressure; PAP, pulmonary arterial pressure; PVR, pulmonary vascular resistance; LHD-PH, pulmonary hypertension due to left heart disease. Comparison of the AUC was carried out by a De Long test.</p

Algorithm of patient selection.

<p>RHC, right heart catheterization; PAP, pulmonary arterial pressure; Pcw, pulmonary capillary wedge pressure; IPAH, idiopathic pulmonary hypertension; CTD-PH, connective tissue disease-associated pulmonary hypertension; CTEPH, chronic thromboembolic pulmonary hypertension; LHD-PH, pulmonary hypertension due to left heart disease.</p

Distribution of PAC in each quartile.

<p>PAC, pulmonary arterial capacitance. * P<0.001.</p

Scatterplot of PVR vs. PAC.

<p>There was a hyperbolic relationship between PAC and PVR. PVR, pulmonary vascular resistance; PAC, pulmonary arterial capacitance.</p

Predictors of cardiac events by Cox proportional hazards model.

<p>Predictors of cardiac events by Cox proportional hazards model.</p

Comparison of LHD-PH patient characteristics of each group.

<p>Comparison of LHD-PH patient characteristics of each group.</p

Correlations between all-day TS and RDI in CHF patients.

<p>Correlations between all-day TS and RDI in CHF patients.</p

Clinical characteristics, HRT, and HRV parameters (N = 75).

<p>HRT, heart rate turbulence; HRV, heart rate variability, NYHA, New York Heart Association; ACE, angiotensin-converting enzyme; ARB, angiotensin II receptor blocker; BNP, B-type natriuretic pepide; eGFR, estimated glomerular filtration; LVEF, left ventricular ejection fraction; RV-FAC, right ventricular fractional area change; RDI, respiratory disturbance index; Lowest SpO₂, lowest oxyhemoglobin saturation; Mean SpO₂, mean oxyhemoglobin saturation; TS, turbulence slope; TO, turbulence onset; SDNN, standard deviation of all NN intervals; SDANN, standard deviation of the averages of the entire recording; RMSSD, the square root of the mean of the sum of the squares of differences between adjacent NN intervals; pNN50, number of pairs of adjacent NN intervals differing by more than 50 ms in the entire recording count divided by the total number of all NN intervals; TP, variance of NN intervals over the temporal segment; VLF, power in the very low frequency component; LF, power in the low-frequency component; HF, power in the high-frequency component.</p>†<p>Data are presented as median (inter quartile range).</p