216 research outputs found

    Cytoplasmic p21Cip1/WAF1 regulates neurite remodeling by inhibiting Rho-kinase activity

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    p21Cip1/WAF1 has cell cycle inhibitory activity by binding to and inhibiting both cyclin/Cdk kinases and proliferating cell nuclear antigen. Here we show that p21Cip1/WAF1 is induced in the cytoplasm during the course of differentiation of chick retinal precursor cells and N1E-115 cells. Ectopic expression of p21Cip1/WAF1 lacking the nuclear localization signal in N1E-115 cells and NIH3T3 cells affects the formation of actin structures, characteristic of inactivation of Rho. p21Cip1/WAF1 forms a complex with Rho-kinase and inhibits its activity in vitro and in vivo. Neurite outgrowth and branching from the hippocampal neurons are promoted if p21Cip1/WAF1 is expressed abundantly in the cytoplasm. These results suggest that cytoplasmic p21Cip1/WAF1 may contribute to the developmental process of the newborn neurons that extend axons and dendrites into target regions

    Environmental Kuznets curve on water pollution in Chinese provinces

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    This study, focusing on the water pollutions in terms of chemical oxygen demand (COD) and ammonia nitrogen by industrial and household discharges in Chinese provinces, investigates the contribution of capacity shortage for pollution control to the provincial pollution levels, by conducting a factor analysis to the heterogeneity of provincial pollutions under the environmental Kuznets curve (EKC) framework. The study’s contribution to the literature lies in its framework of analyzing the heterogeneity of Chinese provinces’ EKCs in terms of their positions (not their shapes) by using a fixed-effect model to extract the province-specific pollution effects. The main finding of this study is that the capacity shortage for pollution control accounts for around 30% as a pollution factor of industrial COD and ammonia nitrogen, and accounts for around 60% and 80% as a pollution factor of household COD and ammonia nitrogen, respectively. It suggests that China has still much policy space and room to mitigate the water pollutions, by building the capacity for pollution control through developing human resources and training them

    Histologic Transformation from Follicular Lymphoma to Diffuse Large B-cell Lymphoma Detected during Colonoscopy

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    A 77-year-old Japanese woman who had been treated for follicular lymphoma for 8 years developed abdominal pain and intra-abdominal lymphadenopathies. Colonoscopy revealed an elevated lesion in the rectum, which presented as two humps with erosions. A diagnosis of histologic transformation of follicular lymphoma to diffuse large B-cell lymphoma was made by endoscopic biopsy. This case underscores the importance of endoscopy examinations and biopsy of newly emerged gastrointestinal lesions for the prompt diagnosis of histologic transformation, since salvage chemotherapy must be initiated quickly in such cases

    Transmission Electoron Microscopic Observation of Drilling Microbiolgical Core Samples form a Deep Seafloor at Hydrothermal Vent Field

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    金沢大学大学院自然科学研究科広島大学University of Papua New GuineaScedule:17-18 March 2003, Vemue: Kanazawa, Japan, Kanazawa Citymonde Hotel, Project Leader : Hayakawa, Kazuichi, Symposium Secretariat: XO kamata, Naoto, Edited by:Kamata, Naoto

    Ⅱ.Impact assessment for fish and wildlife

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    金沢大学大学院自然科学研究科 生命科学Editor : Tazaki, Kazue |田崎, 和
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