国民の代表集団による高齢者のADL、生活の質低下の予防に関するコホート研究:NIPPON DATA

厚生労働科学研究費補助金研究成果報告書研究区分: 厚生科学研究費補助金 総合的プロジェクト研究分野 長寿科学総合研究事業研究年度: 2000報告書区分: 総括文献番号: 200000212A研究代表者: 上島 弘嗣（滋賀医科大学・医学部・教授

国民の代表集団による高齢者のADL、生活の質低下の予防に関するコホート研究:NIPPON DATA

厚生労働科学研究費補助金研究成果報告書研究区分: 厚生科学研究費補助金 総合プロジェクト研究分野 長寿科学総合研究事業研究年度: 1999報告書区分: 総括文献番号: 199900184A研究代表者: 上島 弘嗣（滋賀医科大学・医学部・教授

ジュンカンキ シッカン ノ ハッセイリツ ノ コトナル シュウダン ノ ケッセイ ソウ コレステロール チ ト ショクモツセッシュ ジョウキョウ オヨビ ソノ カンレンセイ

上島弘嗣. 循環器疾患の発生率の異なる集団の血清総コレステロール値と食物摂取状況, およびその関連性. 日本公衆衛生雑誌. 1984. 28(6), p.264-278

疾病予防サービスに係わるエビデンス構築のための大規模コホート共同研究

厚生労働科学研究費補助金研究成果報告書研究区分: 厚生労働科学研究費補助金 疾病・障害対策研究分野 循環器疾患等生活習慣病対策総合研究課題番号: H17-循環器等（生習）-一般-012研究年度: 2007報告書区分: 総合研究代表者: 上島 弘嗣（滋賀医科大学・医学部・教授）研究分担者: 村上 義孝（滋賀医科大学・医学部・講師

青・壮年者を対象とした生活習慣病予防のための長期介入研究

厚生労働科学研究費補助金研究成果報告書研究区分: 厚生科学研究費補助金 健康安全確保総合研究分野 健康科学総合研究事業研究年度: 1999報告書区分: 総括文献番号: 199900844A研究代表者: 上島 弘嗣（滋賀医科大学・医学部・教授）研究分担者: 中村 保幸（滋賀医科大学・医学部・助教授

疾病予防サービスに係わるエビデンス構築のための大規模コホート共同研究

厚生労働科学研究費補助金研究成果報告書研究区分: 厚生労働科学研究費補助金 疾病・障害対策研究分野 循環器疾患等生活習慣病対策総合研究課題番号: H17-循環器等（生習）-一般-012研究年度: 2007報告書区分: 総括文献番号: 200722008A研究代表者: 上島 弘嗣（滋賀医科大学・医学部・教授）研究分担者: 村上 義孝（滋賀医科大学・医学部・講師

P4‐426: Waist Circumference And Domain‐Specific Cognitive Function Among The Non‐Demented Japanese Elderly: Results From The Takashima Study

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/152729/1/alzjjalz2019064098.pd

国民の代表集団による高齢者のADL、生活の質低下の予防に関するコホート研究:NIPPON DATA

厚生労働科学研究費補助金研究成果報告書研究区分: 厚生科学研究費補助金 総合的プロジェクト研究分野 長寿科学総合研究事業研究年度: 2001報告書区分: 総括文献番号: 200100214A研究代表者: 上島 弘嗣（滋賀医科大学・医学部・教授）研究分担者: 岡村 智教（滋賀医科大学・医学部・助教授

Impairments in Activities of Daily Living in Older Japanese Men in Hawaii and Japan

Introduction. Hypertension and cigarette smoking are dominant risk factors for cardiovascular disease in Japan while in westernized countries, broader effects encompass obesity, diabetes, and hypercholesterolemia. This paper examines whether different associations also appear important in the manifestation of activities of daily living (ADL) in older Japanese men in Hawaii and Japan. Methods. Measures of ADL (feeding, toileting, dressing, bathing, and walking around the house) were assessed from 1995 to 1999 in 1,893 men in Hawaii and 543 men in Japan. Concomitant risk factors were measured from 1990 to 1993. Results. In Hawaii, diabetes increased the odds of ≥1 ADL impairment nearly 1.5-fold (P = .020). A similar association was absent in Japan. In contrast, the odds of an ADL impairment in Japan was increased more than 5-fold in the presence of stroke (P < .001). The association in Hawaii was significantly weaker (P = .007). In both cohorts, past alcohol use was associated with a greater likelihood of ADL impairment. Conclusion. In this comparison of genetically similar samples, findings suggest that different strengths in risk factor associations with cardiovascular disease in Japan and westernized countries may also include different strengths in associations with impaired ADL

Relationship between sleep duration and clustering of metabolic syndrome diagnostic components

Sayuri Katano1, Yasuyuki Nakamura1,2, Aki Nakamura1, Yoshitaka Murakami3, Taichiro Tanaka4, Toru Takebayashi5, Akira Okayama6, Katsuyuki Miura2, Tomonori Okamura7, Hirotsugu Ueshima2, for HIPOP-OHP Research Group1Cardiovascular Epidemiology, Kyoto Women&amp;#39;s University, Kyoto, Japan; 2Department of Health Science, Shiga University of Medical Science, Otsu, Japan; 3Department of Medical Statistics, Shiga University of Medical Science, Otsu, Japan; 4Department of Health Sciences, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Japan; 5Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, Japan; 6The First Institute of Health Service, Japan Anti-Tuberculosis Association, Tokyo, Japan; 7Department of Preventive Cardiology, National Cardiovascular Center, Suita, JapanObjective: To examine the relation between sleep duration and metabolic syndrome (MetS).Methods: We examined the baseline data from 4356 healthy workers (3556 men and 800 women) aged 19&amp;ndash;69 years. The physical activity of each participant was classified according to the International Physical Activity Questionnaire (IPAQ). We defined four components of MetS diagnostic components in this study as follows: 1) high blood pressure (BP) systolic BP [SBP] &amp;ge; 130 mmHg, or diastolic BP [DBP] &amp;ge; 85 mmHg, or on medication; 2) dyslipidemia (high-density lipoprotein-cholesterol concentration ,40 mg/dL, or triglycerides concentration &amp;ge;150 mg/dL, or on medication; 3) impaired glucose tolerance (fasting blood sugar concentration &amp;ge; 110 mg/dL, or if less than 8 hours after meals &amp;ge; 140 mg/dL), or on medication; and 4) overweight (body mass index [BMI] &amp;ge; 25 kg/m2), or obesity (BMI &amp;ge; 30 kg/m2). There were 680 participants in the group, with sleep duration &amp;lt;6 hours (15.6%).Results: Those who had 0&amp;ndash;4 MetS diagnostic components, including overweight, accounted for 2159, 1222, 674, 255, and 46 participants, respectively, in the Poisson distribution. Poisson regression analysis revealed that independent factors that contributed to the number of MetS diagnostic components were being male (regression coefficient b = 0.752, P &amp;lt; 0.001), age (b = 0.026, P &amp;lt; 0.001), IPAQ classification (b = -0.238, P = 0.034), and alcohol intake (mL/day) (b = 0.018, P &amp;lt; 0.001). Short sleep duration (&amp;lt;6 hours) was also related to the number of MetS (b = 0.162, P &amp;lt; 0.001). The results of analyses with obesity component showed a similar association.Conclusion: Short sleep duration was positively associated with the number of MetS diagnostic components independent of other lifestyle habits.Keyword: short sleep duration, MetS diagnostic components, obesit