Mass Hierarchy via Mossbauer and Reactor Neutrinos

We show how one could determine the neutrino mass hierarchy with Mossbauer neutrinos and also revisit the question of whether the hierarchy can be determined with reactor neutrinos.Comment: contribution to NOW 2008, 3 pages, 4 figures, late

地球温暖化に伴う熱関連死亡による被害額

地球温暖化により異常高温の頻度・強度の世界的な増加が生じ，またその結果として暑熱に関連した死亡リスクも高まることが懸念されている．本研究では，世界初の試みとして，世界全域を対象地域とした既存の熱関連死亡数の推計手法と統計的生命価値を組み合わせて用いることで，気候および社会・経済の将来変化の不確実性幅を考慮したうえで，気候変動に伴う熱関連死亡リスクの増加について金銭的な見積もりを実施した．その結果，熱関連死亡による被害額のGDP比は，緩和策が進むRCP2.6排出シナリオの場合，世界全体で1%未満に抑えることが可能であること，一方で緩和策が進まないRCP8.5排出シナリオの場合，世界全体で見て今世紀末に2%台となることが示された．また，被害額増加の主因として，現在の途上国では経済発展に伴うVSLの増加の寄与が相対的に大きいこと，現在の先進国は逆に経済発展よりも気候変化の寄与が大きいことがわかった

Genetic Variants of Human Granzyme B Predict Transplant Outcomes after HLA Matched Unrelated Bone Marrow Transplantation for Myeloid Malignancies

Serine protease granzyme B plays important roles in infections, autoimmunity, transplant rejection, and antitumor immunity. A triple-mutated granzyme B variant that encodes three amino substitutions (Q48R, P88A, and Y245H) has been reported to have altered biological functions. In the polymorphism rs8192917 (2364A>G), the A and G alleles represent wild type QPY and RAH mutant variants, respectively. In this study, we analyzed the impact of granzyme B polymorphisms on transplant outcomes in recipients undergoing unrelated HLA-fully matched T-cell-replete bone marrow transplantation (BMT) through the Japan Donor Marrow Program. The granzyme B genotypes were retrospectively analyzed in a cohort of 613 pairs of recipients with hematological malignancies and their unrelated donors. In patients with myeloid malignancies consisting of acute myeloid leukemia and myelodysplastic syndrome, the donor G/G or A/G genotype was associated with improved overall survival (OS; adjusted hazard ratio [HR], 0.60; 95% confidence interval [CI], 0.41–0.89; P = 0.01) as well as transplant related mortality (TRM; adjusted HR, 0.48; 95% CI, 0.27–0.86, P = 0.01). The recipient G/G or A/G genotype was associated with a better OS (adjusted HR, 0.68; 95% CI, 0.47–0.99; P = 0.05) and a trend toward a reduced TRM (adjusted HR, 0.61; 95% CI, 0.35–1.06; P = 0.08). Granzyme B polymorphism did not have any effect on the transplant outcomes in patients with lymphoid malignancies consisting of acute lymphoid leukemia and malignant lymphoma. These data suggest that there is an association between the granzyme B genotype and better clinical outcomes in patients with myeloid malignancies after unrelated BMT

A Service of zbw Leibniz-Informationszentrum Wirtschaft Leibniz Information Centre for Economics Measurement of Use and Non-use Values of Shirakami Mountain Range by using CVM Consistent with TCM

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Measurement of Value of Statistical Life by Evaluating Diarrhea Mortality Risk due to Water Pollution in Laos and Vietnam

Abstract: Diarrhea mortality risk due to water pollution is one of serious problems that threaten human life in Asian developing countries. This study aims to provide basic information for cost-benefit analysis of countermeasures against such a problem in Laos and Vietnam, with a measure of VSL (value of statistical life) concerning diarrhea mortality risk by using CVM (contingent valuation method). With a dataset of questionnaire, the damage cost function explained by the change of diarrhea mortality risk has been derived

光合成微生物の低アスペクト比Taylor渦による培養実験

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NKG2D gene polymorphism has a significant impact on transplant outcomes after HLA-fully-matched unrelated bone marrow transplantation for standard risk hematologic malignancies

NKG2D is an activating and co-stimulatory receptor expressed on natural killer cells and T cells that confers multiple effects in the immune control of microbial infections and malignant disease. As a result, donor and recipient polymorphisms in the NKG2D gene may have an effect on the outcome of allogeneic hematopoietic stem cell transplantations (HSCT). In this study, Dr. Espinoza and colleagues found that the donor NKG2D-HNK1 haplotype was linked to improved overall survival and impaired transplant-related mortality after unrelated, myeloablative conditioned HSCT of patients suffering from hematologic malignancies and reported to the Japan Marrow Donor Program