Filmy Cloud Removal on Satellite Imagery with Multispectral Conditional Generative Adversarial Nets

In this paper, we propose a method for cloud removal from visible light RGB satellite images by extending the conditional Generative Adversarial Networks (cGANs) from RGB images to multispectral images. Satellite images have been widely utilized for various purposes, such as natural environment monitoring (pollution, forest or rivers), transportation improvement and prompt emergency response to disasters. However, the obscurity caused by clouds makes it unstable to monitor the situation on the ground with the visible light camera. Images captured by a longer wavelength are introduced to reduce the effects of clouds. Synthetic Aperture Radar (SAR) is such an example that improves visibility even the clouds exist. On the other hand, the spatial resolution decreases as the wavelength increases. Furthermore, the images captured by long wavelengths differs considerably from those captured by visible light in terms of their appearance. Therefore, we propose a network that can remove clouds and generate visible light images from the multispectral images taken as inputs. This is achieved by extending the input channels of cGANs to be compatible with multispectral images. The networks are trained to output images that are close to the ground truth using the images synthesized with clouds over the ground truth as inputs. In the available dataset, the proportion of images of the forest or the sea is very high, which will introduce bias in the training dataset if uniformly sampled from the original dataset. Thus, we utilize the t-Distributed Stochastic Neighbor Embedding (t-SNE) to improve the problem of bias in the training dataset. Finally, we confirm the feasibility of the proposed network on the dataset of four bands images, which include three visible light bands and one near-infrared (NIR) band

関節リウマチ(RA)患者のNSAIDs長期投与における胃粘膜障害発生因子ならびにファモチジンの治療効果に関する検討

The objective of this study was to investigate the prevalence of gastric mucosal injury induced by nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with rheumatoid arthritis (RA). Upper gastrointestinal endoscopy was performed on 100 RA patients treated with NSAIDs. Patient factors potentially contributing to the development of NSAID-induced gastric mucosal injury were identified by logistic regression analysis; gastric mucosal injury and ulcers were used as objective variables. Gastric mucosal injury was detected in 62 of 100 patients, and eight of these patients had ulcers. Previous history of ulcers, lifestyle, NSAID dosage, and body mass index were associated with the development of gastric mucosal injury, and the use of diclofenac and steroid dose were associated with the development of ulcers. Disease-modifying antirheumatic drugs (DMARDs) did not appear to influence the risk of NSAID-induced gastric mucosal injury. RA patients treated for long periods with NSAIDs for RA symptoms should be controlled with DMARDs, without consideration of increased doses of steroids, in terms of risk for NSAID-induced gastric mucosal injury. Simultaneously, concomitant use of histamine-2 receptor antagonists (H2RA) such as famotidine should be considered.博士（医学）・乙第1354号・平成27年3月16日© Japan College of Rheumatology 2009© Springer International Publishing AG, Part of Springer Science+Business Medi

A ternary complex model of Sirtuin4-NAD+-Glutamate dehydrogenase

Sirtuin4 (Sirt4) is one of the mammalian homologues of Silent information regulator 2 (Sir2), which promotes the longevity of yeast, C. elegans, fruit flies and mice. Sirt4 is localized in the mitochondria, where it contributes to preventing the development of cancers and ischemic heart disease through regulating energy metabolism. The ADP-ribosylation of glutamate dehydrogenase (GDH), which is catalyzed by Sirt4, downregulates the TCA cycle. However, this reaction mechanism is obscure, because the structure of Sirt4 is unknown. We here constructed structural models of Sirt4 by homology modeling and threading, and docked nicotinamide adenine dinucleotide+ (NAD+) to Sirt4. In addition, a partial GDH structure was docked to the Sirt4-NAD+ complex model. In the ternary complex model of Sirt4-NAD+-GDH, the acetylated lysine 171 of GDH is located close to NAD+. This suggests a possible mechanism underlying the ADP-ribosylation at cysteine 172, which may occur through a transient intermediate with ADP-ribosylation at the acetylated lysine 171. These results may be useful in designing drugs for the treatment of cancers and ischemic heart disease

Arthroscopic labral repair concomitantly performed with curved periacetabular osteotomy

A 23-year-old female presented with pain in the left hip. Radiological examination showed developmental dysplasia of the hip (DDH) combined with acetabular retroversion and posterior wall deficiency. Findings in the physical examination were coincident with femoroacetabular impingement. At surgery, we performed curved periacetabular osteotomy concomitant with arthroscopic labral repair and osteochondroplasty, simultaneously addressing dysplastic acetabulum and femoroacetabular impingement. The final follow-up examination at 18 months showed satisfactory outcome with the D’Aubigne and Postel hip score of 17/18. In addition to accurate diagnosis, the arthroscopic procedure for associated intra- and peri-articular problems seems to help improve the surgical outcome of periacetabular osteotomy performed for patients with DDH. Level of evidence IV