Moment Tensor Analysis of Acoustic Emissions Induced by Laboratory-based Hydraulic Fracturing in Granite,

Moment Tensors of hydraulically induced AEs: Hydraulic fracturing is an important technique in the development of enhanced geothermal systems and unconventional resources. Although the fracture modes induced by hydraulic fracturing influence the recovery efficiency of the resources, the current understanding of this relationship is insufficient. In this study, we considered the acoustic emissions (AEs) induced during hydraulic fracturing under uniaxial loading conditions in the laboratory, and applied a moment tensor analysis by carefully correcting the coupling condition and directivity of AE transducers. Experiments were conducted for two types of Kurokami–jima granite samples: those with a rift plane perpendicular (Type H) or parallel (Type V) to the expected direction of fracture propagation (i.e. along the loading axis). In the experiments, both sample types experienced a significant number of shear, tensile and compressive events. The dominant fracture mode for Type H samples is found to be tensile events in which the fracture plane is parallel to the loading axis, whereas for Type V samples, shear events are dominant. This difference suggests that the dominant fracture modes induced by hydraulic fracturing are highly dependent on the relationship between the direction of fracture propagation and orientation of pre-existing weak planes

Clinical Significance of Serum Soluble T Cell Regulatory Molecules in Clear Cell Renal Cell Carcinoma

To clarify the role of serum soluble T cell regulatory molecules in clear cell renal cell carcinoma (CCRCC), we measured the serum levels of soluble interleukin-2 receptor (sIL-2R), soluble B7-H3 (sB7-H3), and soluble cytotoxic T lymphocyte associated antigen-4 (sCTLA-4) in 70 CCRCC patients and 35 healthy controls. We investigated correlations between the serum levels of these soluble T cell regulatory molecules and the pathological grade, clinical stage, and prognosis of CCRCC. We also assessed the relations among each of these soluble molecules. As a result, the serum level of sIL-2R was significantly higher in CCRCC patients than in healthy controls ( < 0.05). In addition, elevation of serum sIL-2R was significantly correlated with the clinical stage ( < 0.001), and the survival of patients with high sIL-2R levels was shorter than that of patients with low sIL-2R levels ( < 0.05). Furthermore, the serum level of sB7-H3 was also significantly correlated with the clinical stage ( < 0.05), while the sIL-2R and sB7-H3 levels showed a positive correlation with each other ( = 0.550, < 0.0001). These results indicate that the serum level of sIL-2R reflects tumor progression in CCRCC patients. In addition, the possibility was suggested that the IL-2/IL-2R and B7-H3 pathways may be involved in the progression of CCRCC

Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism

Ephexin4 is a RhoG-specific guanine nucleotide exchange factor that interacts with the EphA2 receptor in breast cancer cells

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

キョウジセイアイシングケイ : ニスイエンカコバルトニオケルコバルトノカクジキキョウメイ

京都大学0048新制・課程博士理学博士甲第1172号理博第233号新制||理||151(附属図書館)3161UT51-47-B442京都大学大学院理学研究科物理学第一専攻(主査)教授 長谷田 泰一郎, 教授 富田 和久, 教授 松原 武生学位規則第5条第1項該当Kyoto UniversityDA