China's charm offensive and peacekeeping: the lessons of Cambodia – what now for Sudan?

China's participation in UN peacekeeping is often viewed as a part of a global ‘charm offensive’ aimed at enhancing China's image in host countries. However, when viewed in the light of its support for dictatorial regimes in those host countries, do Chinese peacekeeping efforts improve the perceptions local populations have of China? This article examines changes in Cambodian perceptions of China during the UN Transitional Authority in Cambodia (UNTAC) from 1992 to 1993. It argues that China's peacekeeping contribution to UNTAC helped to overcome negative perceptions of that country rooted in its support of the Khmer Rouge before 1992. The key to overcoming current negative perceptions is to project an image of Chinese neutrality with respect to all parties in a civil war. This article concludes by discussing the implication of this argument with regard to China's peacekeeping in Sudan from 2006 to the present, and suggesting that China will need to be more attentive to the needs of other warring factions in the north–south and Darfur conflicts

Why do we need ‘myth-busting’ in the study of Sino–African relations?

The literature on Sino–African relations has debated whether or not China's growing presence is a threat to Western or African interests, and has come to the conclusion that China's behavior is not uniquely immoral. Many countries, including Western liberal democracies, similarly give aid to local autocrats to secure natural resources. Why, then, has so much effort been made to come to this perhaps unsurprising conclusion? We argue that the literature on Chinese foreign policy remains heavily influenced by Western states' policy interests, resulting in an impoverished debate that is primarily concerned with the idea of a China threat. In order to recover the diversity in our research on Chinese foreign policy, we argue for the need to go beyond the confines of Western strategic interests

China's military operations other than war

Although political friction and ideological differences between China and the West can hamper co-operation on missions known as ‘Military Operations Other than War’, the UK and China have achieved a certain level of success in this regard, particularly in relation to UN peacekeeping and counter-piracy operations. In this article, Miwa Hirono and Manshu Xu argue that the key has been to use multilateral platforms to frame bilateral collaboration, thereby diminishing Chinese perceptions of the associated political risks. Thus it is useful for Western militaries to exploit multilateralism to make military co-operation more attractive to Chin

Lesion of the Cerebellar Noradrenergic Innervation Enhances the Harmaline-Induced Tremor in Rats

Abnormal synchronous activation of the glutamatergic olivo-cerebellar pathway has been suggested to be crucial for the harmaline-induced tremor. The cerebellum receives two catecholaminergic pathways: the dopaminergic pathway arising from the ventral tegmental area/substantia nigra pars compacta, and the noradrenergic one from the locus coeruleus. The aim of the present study was to examine a contribution of the cerebellar catecholaminergic innervations to the harmaline-induced tremor in rats. Rats were injected bilaterally into the cerebellar vermis with 6-hydroxydopamine (6-OHDA; 8 μg/0.5 μl) either alone or this treatment was preceded (30 min earlier) by desipramine (15 mg/kg ip). Harmaline was administered to animals in doses of 7.5 or 15 mg/kg ip. Tremor of forelimbs was measured as a number of episodes during a 90-min observation. Rats were killed by decapitation 30 or 120 min after harmaline treatment. The levels of dopamine, noradrenaline, serotonin, and their metabolites were measured by HPLC in the cerebellum, substantia nigra, caudate–putamen, and frontal cortex. 6-OHDA injected alone enhanced the harmaline-induced tremor. Furthermore, it decreased the noradrenaline level by ca. 40–80% in the cerebellum and increased the levels of serotonin and 5-HIAA in the caudate–putamen and frontal cortex in untreated and/or harmaline-treated animals. When 6-OHDA treatment was preceded by desipramine, it decreased dopaminergic transmission in some regions of the cerebellum while inducing its compensatory activation in others. The latter lesion did not markedly influence the tremor induced by harmaline. The present study indicates that noradrenergic innervation of the cerebellum interacts with cerebral serotonergic systems and plays an inhibitory role in the harmaline-induced tremor

Assessment of the Red Cell Proteome of Young Patients with Unexplained Hemolytic Anemia by Two-Dimensional Differential In-Gel Electrophoresis (DIGE)

Erythrocyte cytosolic protein expression profiles of children with unexplained hemolytic anemia were compared with profiles of close relatives and controls by two-dimensional differential in-gel electrophoresis (2D-DIGE). The severity of anemia in the patients varied from compensated (i.e., no medical intervention required) to chronic transfusion dependence. Common characteristics of all patients included chronic elevation of reticulocyte count and a negative workup for anemia focusing on hemoglobinopathies, morphologic abnormalities that would suggest a membrane defect, immune-mediated red cell destruction, and evaluation of the most common red cell enzyme defects, glucose-6-phosphate dehydrogenase and pyruvate kinase deficiency. Based upon this initial workup and presentation during infancy or early childhood, four patients classified as hereditary nonspherocytic hemolytic anemia (HNSHA) of unknown etiology were selected for proteomic analysis. DIGE analysis of red cell cytosolic proteins clearly discriminated each anemic patient from both familial and unrelated controls, revealing both patient-specific and shared patterns of differential protein expression. Changes in expression pattern shared among the four patients were identified in several protein classes including chaperons, cytoskeletal and proteasome proteins. Elevated expression in patient samples of some proteins correlated with high reticulocyte count, likely identifying a subset of proteins that are normally lost during erythroid maturation, including proteins involved in mitochondrial metabolism and protein synthesis. Proteins identified with patient-specific decreased expression included components of the glutathione synthetic pathway, antioxidant pathways, and proteins involved in signal transduction and nucleotide metabolism. Among the more than 200 proteins identified in this study are 21 proteins not previously described as part of the erythrocyte proteome. These results demonstrate the feasibility of applying a global proteomic approach to aid characterization of red cells from patients with hereditary anemia of unknown cause, including the identification of differentially expressed proteins as potential candidates with a role in disease pathogenesis