2 research outputs found
Spatiotemporal Control of Electrokinetic Transport in Nanofluidics Using an Inverted Electron-Beam Lithography System
Manipulation
techniques
of biomolecules have been proposed for biochemical analysis which
combine electrokinetic dynamics, such as electrophoresis or electroosmotic
flow, with optical manipulation to provide high throughput and high
spatial degrees of freedom. However, there are still challenging problems
in nanoscale manipulation due to the diffraction limit of optics.
We propose here a new manipulation technique for spatiotemporal control
of chemical transport in nanofluids using an inverted electron-beam
(EB) lithography system for liquid samples. By irradiating a 2.5 keV
EB to a liquid sample through a 100-nm-thick SiN membrane, negative
charges can be generated within the SiN membrane, and these negative
charges can induce a highly focused electric field in the liquid sample.
We showed that the EB-induced negative charges could induce fluid
flow, which was strong enough to manipulate 240 nm nanoparticles in
water, and we verified that the main dynamics of this EB-induced fluid
flow was electroosmosis caused by changing the zeta potential of the
SiN membrane surface. Moreover, we demonstrated manipulation of a
single nanoparticle and concentration patterning of nanoparticles
by scanning EB. Considering the shortness of the EB wavelength and
Debye length in buffer solutions, we expect that our manipulation
technique will be applied to nanomanipulation of biomolecules in biochemical
analysis and control
Spatiotemporal Control of Electrokinetic Transport in Nanofluidics Using an Inverted Electron-Beam Lithography System
Manipulation
techniques
of biomolecules have been proposed for biochemical analysis which
combine electrokinetic dynamics, such as electrophoresis or electroosmotic
flow, with optical manipulation to provide high throughput and high
spatial degrees of freedom. However, there are still challenging problems
in nanoscale manipulation due to the diffraction limit of optics.
We propose here a new manipulation technique for spatiotemporal control
of chemical transport in nanofluids using an inverted electron-beam
(EB) lithography system for liquid samples. By irradiating a 2.5 keV
EB to a liquid sample through a 100-nm-thick SiN membrane, negative
charges can be generated within the SiN membrane, and these negative
charges can induce a highly focused electric field in the liquid sample.
We showed that the EB-induced negative charges could induce fluid
flow, which was strong enough to manipulate 240 nm nanoparticles in
water, and we verified that the main dynamics of this EB-induced fluid
flow was electroosmosis caused by changing the zeta potential of the
SiN membrane surface. Moreover, we demonstrated manipulation of a
single nanoparticle and concentration patterning of nanoparticles
by scanning EB. Considering the shortness of the EB wavelength and
Debye length in buffer solutions, we expect that our manipulation
technique will be applied to nanomanipulation of biomolecules in biochemical
analysis and control