Lipid control profile in patients with acute coronary syndrome at Tokushima Prefectural Central Hospital

In Japan atherosclerosis society guideline, it is recommended for secondary prevention of acute coronary syndrome to manage lipid. In particular, hyper-LDLemia is known to develop and promote atherosclerosis, and lowering the LDL-C level leads to suppression of recurrence of atherosclerosis. We investigated the profile of lipid control in patients who succeeded in percutaneous coronary intervention for acute coronary syndrome（ACS）at our hospital, and examined by high risk patients（chronic kidney disease, diabetes, obesity）. The achievement rate of LDL-C <１００ at discharge was６２％ of all cases, and the achievement rate of LDL-C <７０was only１６％. In particular, only１２％ of obese patients achieved LDL-C <７０. In recent years, it has been shown that additional administration of ezetimibe or PCSK９ inhibitor to statins further lowers LDL-C and significantly reduces the risk of developing cardiovascular disease. We should recognize that some ACS patients have not reached their goals and actively treat them for secondary prevention

Structural characteristics of phycobiliproteins from red alga Mazzaella japonica

We determined the primary structures of phycoerythrin (PE), phycocyanin (PC), and allophycocyanin (APC) from red alga Mazzaella japonica. The phycobiliproteins consist of a- and b- subunits like other red algae. M. japonica phycobiliproteins all conserved Cys residues for chromophore attachment site. The amino acid sequences of M. japonica phycobiliproteins showed considerably high identities with those of other red algae (81-100%). In addition, the sequences (YRD, LDY, LRY, VY, LF, and FY), which were angiotensin I converting enzyme (ACE) inhibitory peptides from other algae were detected in the primary structures of M. japonica phycobiliproteins. Then, we prepared the protein hydrolysates from M. japonica and measured its ACE inhibitory activity. Consequently, M. japonica protein hydrolysates indicated considerably high ACE inhibitory activity

Reordering Model Using Syntactic Information of a Source Tree for Statistical Machine Translation

Abstract This paper presents a reordering model using syntactic information of a source tree for phrase-based statistical machine translation. The proposed model is an extension of IST-ITG (imposing source tree on inversion transduction grammar) constraints. In the proposed method, the target-side word order is obtained by rotating nodes of the source-side parse-tree. We modeled the node rotation, monotone or swap, using word alignments based on a training parallel corpus and sourceside parse-trees. The model efficiently suppresses erroneous target word orderings, especially global orderings. Furthermore, the proposed method conducts a probabilistic evaluation of target word reorderings. In Englishto-Japanese and English-to-Chinese translation experiments, the proposed method resulted in a 0.49-point improvement (29.31 to 29.80) and a 0.33-point improvement (18.60 to 18.93) in word BLEU-4 compared with IST-ITG constraints, respectively. This indicates the validity of the proposed reordering model

A Case of Effective Mepolizumab Induction Therapy for Severe Eosinophilic Granulomatosis with Polyangiitis Diagnosed by Eosinophilic Cholecystitis and Interstitial Nephritis

A 66-year-old man with a history of bronchial asthma and sinusitis was admitted with cholecystitis and peripheral neuropathy. The histopathological findings of the gallbladder revealed necrotic vasculitis and granulomatous inflammation with marked eosinophilic infiltration. Kidney biopsy also showed marked eosinophilic infiltration in the tubulointerstitial area and eosinophilic tubulitis. He was diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA) and treated with corticosteroids. However, he showed no response. Therefore, he was administered mepolizumab 300 mg, which resulted in clinical improvement, including normalization of the eosinophil and CRP levels. We herein describe the first case of successful induction therapy of EGPA using mepolizumab

Galanin-Containing Nerve Nets in Hydra (Hydra japonica) and Freshwater Medusa (Craspedacusta sowerbyi)

Immunohistochemical analyses were performed to determine the distribution of galanin-like immunoreactivity in the hydra (Hydra japonica) and freshwater medusa (Craspedacusta sowerbyi). In the hydra, galanin-immunoreactive (Gal-IR) fibers were restricted in the tentacle and basal disk. Although Gal-IR somata were obscure, swollen parts were seen along the course of Gal-IR fibers. In the medusa, galanin-like immunoreactivity was restricted to the subumbrella. Bipolar and multipolar Gal-IR somata and fibers formed a circular nerve net in the subumbrella and Gal-IR fibers projected to the lateral edge of the subumbrella from this Gal-IR circular nerve net. The presence of galanin-like immunoreactivity in these most primitive animals with a nervous system suggested that galanin is an one of the phylogenetically oldest neuropeptides in addition to other neuropeptides such as FMRF amide and substance P

Galanin-Containing Nerve Nets in Hydra (Hydra japonica) and Freshwater Medusa (Craspedacusta sowerbyi)

Immunohistochemical analyses were performed to determine the distribution of galanin-like immunoreactivity in the hydra (Hydra japonica) and freshwater medusa (Craspedacusta sowerbyi). In the hydra, galanin-immunoreactive (Gal-IR) fibers were restricted in the tentacle and basal disk. Although Gal-IR somata were obscure, swollen parts were seen along the course of Gal-IR fibers. In the medusa, galanin-like immunoreactivity was restricted to the subumbrella. Bipolar and multipolar Gal-IR somata and fibers formed a circular nerve net in the subumbrella and Gal-IR fibers projected to the lateral edge of the subumbrella from this Gal-IR circular nerve net. The presence of galanin-like immunoreactivity in these most primitive animals with a nervous system suggested that galanin is an one of the phylogenetically oldest neuropeptides in addition to other neuropeptides such as FMRF amide and substance P.6KJ00000173842

Calcitonin gene-related peptide-like nervous system in the optic lobe and peduncle complex of the octopus, Octopus vulgaris

Calcitonin gene-related peptide (CGRP)-like immunoreactivity was examined in the octopus optic lobe and pedunclule complex by immunohistochemistry and biochemistry. In the optic lobe cortex, CGRP-immunoreactive somata were scattered in the inner granular cell layer but not in the outer granular cell layer. In the optic lobe medulla, scattered CGRP-immunoreactive somata were seen in the cell island and many immunoreactive varicose fibers were observed in the surrounding neuropil. In the peduncle lobe, immunoreactive somata were seen in the cell layer of the basal zone, but not in that layer of the spine. Based on the size of the immunoreactive somata, these CGRP-immunoreactive cells may correspond to the projection neurons from the basal zone to the motor areas of the central brain. Immunoreactive varicose fibers were observed in the basal zone neuropil, but only a few in the spine neruopil. In the olfactory lobe, many immunoreactive somata were seen in the posterior olfactory lobule, but only a few in the median olfactory lobule. We found no immunoreactive somata in the anterior olfactory lobule. However, immunoreactive varicose fibers and puncta were abundant in the neuropils of these three lobules. Western blot analysis indicated that the used anti-rat CGRP antiserum detected an approximate 31.6 kDa band from optic lobe extracts, which may be a precursor form or the active form of a CGRP-like peptide in the octopus. These results suggest that a CGRP-like substance is present in the octopus optic lobe and peduncle complex and that the substance functions as a neuromodulator in the octopus nervous system similar in the vertebrate brain.6KJ00004125978